1. Team West Pharmaceutical Sponsor: Tim Miller Adviser: Dr. Harris

2. Sponsor and Business Leadership in Drug Administration Systems and Components Project Focus: rubber manufacturing for various rubber device components

3. The Problem Rubber is being tested far too late in the manufacturing process and takes too long Results in excessive material waste, as production continues with wrong formulations

4. Project Scope Create a rapid, at-line testing method to determine whether a rubber compound was properly mixed and will cure correctly.

5. Technical Basis Focus on Rubber Production Scorch time, cure rate, performance, viscosity Factors relate to quality of batch

6. Questions?

7. Wants/Needs/Constraints Wants –Simple Readout –Cost Effective –Automated Needs –Accuracy of Prediction –Fast Testing –Minimize amount of sample destroyed Constraints –OSHA –FDA

8. Key Metrics MetricTarget Uncertainty± 2σ Time< 10 min Weight Destroyed< 1/2 lb

9. Selected Concept At-Line Viscosity Compression Test

10. Supporting Theory

11. Preliminary Testing Tests were performed in the CCM to verify testing method using the Instron 5567

12. Design Determine Viscosity via compression test

13. Fabrication The device was built from a combination of purchased motor components and machined framework

14. Calibrations and Programming Labview & GalilTools –Automatically converts and sends appropriate commands to the controller –Allows user to set number of data points –Safeguard to power off motors before critical loads are reached.

15. Video

16. Results and Statistical Analysis SampleViscosity (lb-s/in 2 ) A10.0055 A20.0052 A30.0055 A40.0056 A50.0058 A60.0059 Standard Deviation = 2.48×10 -4 (lb-s/in^2) Viscosity factor= (w^4)*8*(1/(h^3))*dh/dt

17. Meeting Key Metrics

18. Deliverables Prototype with ability to perform the desired tests Labview program for controlling the tests Method for performing tests and gaining useful data

19. Path Forward More Calibration Testing Develop a more polished program Build Database of viscosity data The device needs to be a bit more refined, with proper electrical enclosures

20. Cost Summary Sponsor given range: $5,000 Actual Costs: $4,851.67 –Zaber: Stepper Motors-> $1222.00 –McMaster Carr and Materials-> $733.67 –Galil: Controller-> $1817.00 –Omega: Load Cell->$1079.00

21. Thank You Comments/Questions?