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2. Owned, published, and © copyrighted, 2001, by the MASSACHUSETTS MEDICAL SOCIETY. Published by Massachusetts Medical Society. 2 Figure 1 Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock. Rivers, Emanuel; Nguyen, Bryant; Havstad, Suzanne; Ressler, Julie; Muzzin, Alexandria; Knoblich, Bernhard; Peterson, Edward; Tomlanovich, Michael New England Journal of Medicine. 345(19):1368-1377, November 8, 2001. Figure 1. Overview of Patient Enrollment and Hemodynamic Support. SIRS denotes systemic inflammatory response syndrome, CVP central venous pressure, MAP mean arterial pressure, ScvO(2)) central venous oxygen saturation, SaO(2)) arterial oxygen saturation, and V(dotover)O(2)) systemic oxygen consumption. The criteria for a diagnosis of SIRS were temperature greater than or equal to 38 degreesC or less than 36 degreesC, heart rate greater than 90 beats per minute, respiratory rate greater than 20 breaths per minute or partial pressure of arterial carbon dioxide less than 32 mm Hg, and white-cell count greater than 12,000 per cubic millimeter or less than 4000 per cubic millimeter or the presence of more than 10 percent immature band forms.

3. Owned, published, and © copyrighted, 2001, by the MASSACHUSETTS MEDICAL SOCIETY. Published by Massachusetts Medical Society. 3 Figure 2 Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock. Rivers, Emanuel; Nguyen, Bryant; Havstad, Suzanne; Ressler, Julie; Muzzin, Alexandria; Knoblich, Bernhard; Peterson, Edward; Tomlanovich, Michael New England Journal of Medicine. 345(19):1368-1377, November 8, 2001. Figure 2. Protocol for Early Goal-Directed Therapy. CVP denotes central venous pressure, MAP mean arterial pressure, and ScvO(2)) central venous oxygen saturation.

4. Owned, published, and © copyrighted, 2001, by the MASSACHUSETTS MEDICAL SOCIETY. Published by Massachusetts Medical Society. 4 Table 1 Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock. Rivers, Emanuel; Nguyen, Bryant; Havstad, Suzanne; Ressler, Julie; Muzzin, Alexandria; Knoblich, Bernhard; Peterson, Edward; Tomlanovich, Michael New England Journal of Medicine. 345(19):1368-1377, November 8, 2001. Table 1. Base-Line Characteristics of the Patients.

5. Owned, published, and © copyrighted, 2001, by the MASSACHUSETTS MEDICAL SOCIETY. Published by Massachusetts Medical Society. 5 Table 2 Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock. Rivers, Emanuel; Nguyen, Bryant; Havstad, Suzanne; Ressler, Julie; Muzzin, Alexandria; Knoblich, Bernhard; Peterson, Edward; Tomlanovich, Michael New England Journal of Medicine. 345(19):1368-1377, November 8, 2001. Table 2. Vital Signs, Resuscitation End Points, Organ- Dysfunction Scores, and Coagulation Variables.

6. Owned, published, and © copyrighted, 2001, by the MASSACHUSETTS MEDICAL SOCIETY. Published by Massachusetts Medical Society. 6 Table 3 Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock. Rivers, Emanuel; Nguyen, Bryant; Havstad, Suzanne; Ressler, Julie; Muzzin, Alexandria; Knoblich, Bernhard; Peterson, Edward; Tomlanovich, Michael New England Journal of Medicine. 345(19):1368-1377, November 8, 2001. Table 3. Kaplan-Meier Estimates of Mortality and Causes of In-Hospital Death.

7. Owned, published, and © copyrighted, 2001, by the MASSACHUSETTS MEDICAL SOCIETY. Published by Massachusetts Medical Society. 7 Table 4 Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock. Rivers, Emanuel; Nguyen, Bryant; Havstad, Suzanne; Ressler, Julie; Muzzin, Alexandria; Knoblich, Bernhard; Peterson, Edward; Tomlanovich, Michael New England Journal of Medicine. 345(19):1368-1377, November 8, 2001. Table 4. Treatments Administered.