1. Innovation Acceleration Partner Fellows Program Approaches to Improving Commercialization and Innovation National Science Foundation Partner for Innovation Award ID: 0650294 W ashington University in St. Louis and the University of Missouri-Columbia Presented to: Tiger/Kauffman Sponsored Workshop February 27, 2010 Ken Harrington Washington University in St. Louis Innovation Acceleration Partner Fellows Program Approaches to Improving Commercialization and Innovation National Science Foundation Partner for Innovation Award ID: 0650294 W ashington University in St. Louis and the University of Missouri-Columbia Presented to: Tiger/Kauffman Sponsored Workshop February 27, 2010 Ken Harrington Washington University in St. Louis

2. Overview 1.Grant goals 2.Approach 3.First year outcomes 4.Issues for year two 5.Valley of Death

3. Grant Goals 1.Train fellows 2.Reduce roadblocks that discourage faculty 3.Find new innovation models 4.Move science from bench to the market 5.Enhance the culture

4. Targeted Roadblocks 1.Lack of time 2.Limited understanding of the commercialization process 3. Lack collaborative social network 4. Fear of publication delays

5. Approach 1.Focus on researchers 2.Work within the existing framework 3.Provide new support to researcher 4.Discuss possibilities openly 5.Consider “breakthrough” approaches

6. Involved Parties

7. Concept-Pre Disclosure Support

8. Outcomes-Two Innovation Models

9. Measurements

10. Wash U Basic Science Model

11. IAP Fellows  Amit Kumar  Ph.D. Molecular Biophysics  Justin Brown  Ph.D. Pharmacology  Kunal Rehani  Ph.D. Immunology

12. Overview of Wash U Technologies Triage I Criteria: Technology Licensing or start-up Stage of development Intellectual Property (IP) Triage II Criteria: Triage I Criteria AND… OTM approval Inventor enthusiasm Market analysis FDA regulatory process

13. Opportunity Evaluation Tool

14. Majority OTM Supplied 75 Opportunities

15. Five Opportunities Selected

16. Other Potential Opportunities

17. Mizzou BioDesign Model

18. BioDesign Fellows  Rebecca Rone  MS BioEngineering  Anthony Harris  MD/MBA  Jonathan Thompson Jr.  MD

19. Three Phases of Biodesign  Phase One (Physician) Clinical Emersion  Phase Two (Engineer) Product design  Phase Three (MBA) Business Development MD MBA ENG Critical Mass

20. Program Detail – Applied Research Needs & Solutions ProductProduct Business Plan

21. Tools: Needs Database

22. Rapid Indexing

23. First Year  15 Invention Disclosures 1/8 of all FY09 Columbia campus disclosures  2 Provisional Patents Filed  Prototype animal testing  Founding of Limited Liability Company SBIR application submitted Missouri LSRB commercialization letter of intent

24. MU Invention Disclosures  9 Minimally Invasive Devices  3 Real Time Patient Monitoring Devices  2 Minimally Invasive Cosmetic Devices  1 Laparoscopic Trainer

25. Innovation Model Constraints

26. Entrepreneurial expectancy Perceived need for new outcome Entrepreneurial self-efficacy Entrepreneurial intent Entrepreneurial desirability. Have idea for start-up Fellows’ Impact What Environmental Factors are the Multipliers Creating Entrepreneurial Intent?

27. Year 2 Issues Logic  # quality opportunities  # undisclosed opportunities  # concurrent projects Triage Types of technology Start-up Environment  Fellows’ skills  Duration of fellowship  Fellow funding ($60K@)  Proof of concept and prototype funding ($TBD)  Patent funding  Transaction costs & time

28. Valley of Death Proof of Concept Funding Lower Transaction Cost Faster Resource Access Entrepreneurial Partner Rapid Prototyping Invention Disclosure Rapid Prototyping Value Milestone Regulatory Process Faster Decisions

29. Key Questions? 1.Process improvement? 2.Structural change? 3.Amount of resources? 4.Sustainability? 5.Level of breakthrough

30. Contact Information Ken Harrington, Managing Director Skandalaris Center for Entrepreneurial Studies Washington University in St. Louis Campus Box 1133 One Brookings Drive St. Louis, Missouri 63130 314-935-9134 harrington@wustl.edu http://www.sces.wustl.edu/ http://www.ideabounce.com/ harrington@wustl.edu http://www.sces.wustl.edu/ http://www.ideabounce.com/