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Experimental genomics of fitness in yeast by Graham Bell Proceedings B Volume 277(1687):1459-1467 May 22, 2010 ©2010 by The Royal Society.

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Presentation on theme: "Experimental genomics of fitness in yeast by Graham Bell Proceedings B Volume 277(1687):1459-1467 May 22, 2010 ©2010 by The Royal Society."— Presentation transcript:

1 Experimental genomics of fitness in yeast by Graham Bell Proceedings B Volume 277(1687):1459-1467 May 22, 2010 ©2010 by The Royal Society

2 Distribution of standard yield among deletion strains in complete (YPD) medium. Graham Bell Proc. R. Soc. B 2010;277:1459-1467 ©2010 by The Royal Society

3 Distribution of maximum growth rate among deletion strains in complete (YPD) medium. Graham Bell Proc. R. Soc. B 2010;277:1459-1467 ©2010 by The Royal Society

4 Distribution of selection coefficients among deletion strains in complete (YPD) medium. Graham Bell Proc. R. Soc. B 2010;277:1459-1467 ©2010 by The Royal Society

5 Relative growth of heterozygote and homozygote deletion strains in a competition pool assay. Graham Bell Proc. R. Soc. B 2010;277:1459-1467 ©2010 by The Royal Society

6 Epistasis in crosses between deletion strains with low growth rates. Graham Bell Proc. R. Soc. B 2010;277:1459-1467 ©2010 by The Royal Society

7 Distribution of genetic correlation over environments for the deletion strains. Graham Bell Proc. R. Soc. B 2010;277:1459-1467 ©2010 by The Royal Society

8 ‘Shellburst’ plot of variance on mean for the Parsons dataset (82 media). Graham Bell Proc. R. Soc. B 2010;277:1459-1467 ©2010 by The Royal Society

9 The cumulative frequency of conditional sublethal loci when the deletion set is tested over a large number of substrates. ‘Subvital’ is defined as lying 2 s.d. units or more below average in pool competition experiments. Graham Bell Proc. R. Soc. B 2010;277:1459-1467 ©2010 by The Royal Society

10 Frequency of deletions among natural isolates in relation to geometric mean fitness in culture. Graham Bell Proc. R. Soc. B 2010;277:1459-1467 ©2010 by The Royal Society


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