1. Allocated to IV arm (n=85) Allocated to HIA arm (n=86) Started allocated intervention (n=83) Did not receive allocated therapy (n=2) - Refusal (n=2) Started allocated intervention (n=66) Did not receive allocated therapy (n=20) - Refusal (n=2) - progressive disease (n=3) - Catheter placement (n=13) - Other (n=2) Lost to follow-up (n=2) Discontinued intervention (n=66) - Progression (n=37) - Toxicity (n=14) - Catheter dysfunction (n=11) - Refusal (n=1) - Other (n=3) Lost to follow-up (n=3) Discontinued intervention (n=83) - Progression (n=59) - Toxicity (n=22) - Catheter dysfunction (not applicable) - Refusal (n=1) - Other (n=1) Randomized (n=171) Ineligible (n=3) Excluded (n=0) ITT population (n=85) Per-protocol treatment population (n=83) ITT population (n=86) Per-protocol treatment population (n=66) Allocation Follow-up Analysis FIGURE S1

2. Logrank test: P=0.03 % patients alive FIGURE S2

3. Logrank test: P<0.0001 % patients alive < UNL UNL - < 2xUNL > 2xUNL FIGURE S3