1. V. Breton, Budapest, September 2002 WP10 status V. Breton DataGrid conference

2. V. Breton, Budapest, September 2002 WP10 goals between now and the end of the year Deploy the applications listed in deliverable D10.2 –Test algorithms on a significant scale (several tens of CPU) to get biomedically meaningful results –Demonstrate the relevance of grids to handle biomedical data and metadata Have DataGrid nodes in biomedical laboratories –Need for training of system engineers to install EDG in their lab Write D10.3 deliverable describing our results on the testbed

3. V. Breton, Budapest, September 2002 List of applications Bio-informatics –Bio-informatics web portal : IBCP (C. Blanchet) –Parasitology : LBP Clermont (N. Jacq) –Phylogenetics : BBE Lyon (T. Sylvestre) –Search for primers : Centrale Paris (K. Kurata) –Statistical genetics : CNG Evry (N. Margetic) –Update and mirroring of genomics data bases : LPC Clermont (Y. Legrè) Medical imaging –MR image simulation: CREATIS (H. Benoit-Cattin) –Medical data and metadata management : CREATIS (J. Montagnat) –Simulation platform for PET/SPECT based on Geant4 : GATE collaboration (L. Maigne)

4. V. Breton, Budapest, September 2002 GATE, a PET/SPECT simulation platform Goal : dGoal : develop a generic simulation platform for nuclear medecine based on GEANT4 –Crystal Clear ClearPET project of a microPET for small animals imaging –Deploy CPU intensive simulations on a grid environment 9 laboratories involved –From CC ClearPET : IPHE Lausanne (Spokesman : C. Morel), Univ. Bruxelles, Univ. Gent, CERMEP Lyon, Sungkyunkwan University and CHU Nantes (U463 INSERM) –Outside Crystal Clear : LPC Clermont-Fd, INSERM U494 Pitié-Salpêtrière, SHFJ Orsay

5. V. Breton, Budapest, September 2002 GATE unique potentialities take advantage of GEANT4 toolkit and new developments SCANNER DESCRIPTION Geometry  script (detectors, materials, …) Properties  spectral resolution… RADIOACTIVE SOURCES Radioactive decay Digital images  complex emission and absorption cards TIME Physical dynamics : decay Biological dynamics : drug kinetics Movements DYNAMICS Detector continuous movement  rotation: SPECT, PET  specific moves Source movement  patient (heart beat…)  external source USER FRIENDLY  graphical interface  user guide, examples

6. V. Breton, Budapest, September 2002 Status of GATE gridification Successful test of Geant4.4.0 execution on testbed1 at CC-IN2P3 (July 2002) To be done –a web portal for GATE/GEANT4 simulations on DataGrid

7. V. Breton, Budapest, September 2002 The challenges of tomorrow Understanding the genome Integrating genetic data into medical records To reach individualized health care Bioinformatics Medical Imaging Medical informatics Public Health Martin-Sanchez et al, MIM 41 (2002) 25-30

8. V. Breton, Budapest, September 2002 What could be individualized health care… INDIVIDUALISED HEALTHCARE MOLECULAR MEDECINE Databases Association Modelling Computation Computational recommandation Patient related data PublicHealth Patient Tissue, organ Cell Molecule PublicHealth Patient Tissue, organ Cell Molecule S. Norager Y. Paindaveine DG- INFSO

9. V. Breton, Budapest, September 2002 The bottlenecks –The complexity and diversity of life Exponential growth of the volume of data coming from genomics and post-genomics –The lack of synergy between the scientific communities Physicians legitimately focussed on improving daily practice Biologists legitimately focussed on long term understanding The steps toward individualized healthcare –Foster the synergy between bio-informatics and medical informatics –Provide the environment where medical and bio-informatics data can be stored and analyzed together Toward individualized health care

10. V. Breton, Budapest, September 2002 EC vision of HealthGrid w.r.t. GridStart cluster EUROGRID DATAGRID DAMIEN CROSSGRID GRIDSTART Only health related GRID’s Multidisciplinary GRID’s GEMSS HEALTHGRID CLUSTER BIOGRID MAMMOGRID Public Health Patient Tissue, organ Cell Molecule Public health informatics Medical Informatics Medical Imaging Bio-informatics Figure 1 ETC.

11. V. Breton, Budapest, September 2002 Calendar September –Cluster meeting of the 5 health related grid projects approved in 2002 DataGrid invited to present its experience in deploying biomedical applications on a grid –EC starts writing first calls for proposals November –BioInfoMed white paper circulated December –Open meeting on health grids in Brussels –Official call for proposal In the mean time, healthgrid distribution list used to identify a community for an health grid

12. V. Breton, Budapest, September 2002 WP10 concerns… That quality becomes the reason why developments needed by WP9/WP10 are postponed beyond the end of the project. That LHC data challenges saturate the testbed although we understand their importance

13. V. Breton, Budapest, September 2002 Application Technical Working Group Several discussions between application WPMs and technical coordination to refocus the ATWG on the common needs of all applications Proposal is being circulated among the members of TWG HEPEOBio Common applicative layer EDG software Globus

14. V. Breton, Budapest, September 2002 Conclusion WP10 is ready to deploy its applications and to get more strongly involved in ATWG WP10 is willing to promote EDG middleware within the biomedical community … –New healthgrid cluster started by the EC But we need your help for this task –Room for medium to large scale tests on testbed –Training and support for system administrators –Continuous interest for WP10 requirements