1. 神经信息学Neuroinformatics Spring semester, 2009

2. LECTURE 1 Introduction

3. 武志华 · 中科院生物物理所， 脑与认知科学国家重点实验室， 副研究员 · Tel: 64869355 Email: wuzh@moon.ibp.ac.cn

4. 史忠植 · 中科院计算技术研究所, 智能科学实验室， 研究员 · 人工智能 （神经计算）

5. 教学按排 每周四 : 8:50-11:40 40 学时, 2 学分 3 学时 / 每次 地点：玉泉路园区 305 闭卷笔试 笔试内容与作业的关系

6. 引言 － 1994 年, 汪云九老师在中科院研究生院开设 “ 神经信息学 ” 课程。 － What is Neuroinformatics?

7. What is I. Neuroinformatics? II.Computational Neuroscience ( 计算神经科学 )? III. Theoretical Neuroscience? IV.Neurocomputing ( 神经计算 )? V.Why we learn “Neuroinformatics” or “Computational Neuroscience” ? VI. Course structure

8. 1. databases of neuroscience data, 2. tools for management, sharing, analyzing and modeling of neuroscience data at all levels of analysis, 3. computational models of the nervous system and neural processes Neuroinformatics Neuroinformatics is a research field including the development of: Neuro- science Information science Neuro- informatics

9. Vast amounts of diverse data about the brain was gathered ( 汪云九老师 )

10. Human Brain Project 1993 年 “ 人类脑计划（ Human Brain Project ） ” 的第一批项目公布， 标志着人类脑计划正式启动 Idea emerged in 1991: Mapping the brain and its functions. Integrating enabling technologies into neuroscience research Neuroinformatics uses databases, the Internet, and visualization in the storage and analysis of the neuroscience data (A name similar to Human Genome Project)

11. SenseLab ( http://senselab.med.yale.edu)

12. 1 3 2

16. BrainMaps.org ( http:// brainmaps.org)

17. Explore BrainMaps data in 3D

18. Neuroinformatics = Databases + Tools + Computational Models

19. What is I. Neuroinformatics? II.Neurocomputing ( 神经计算 )? III. Theoretical Neuroscience? IV.Computational Neuroscience ( 计算神经科学 )? V.Why we learn “Neuroinformatics” or “Computational Neuroscience” ? VI. Course structure

20. Neurocomputing is concerned with processing information: 1. It involves a learning process within an artificial neural network architecture 2. The trained networks can be used to perform certain tasks depending on the particular application 3. Neurocomputing can play an important role in solving certain difficult problems in science and engineering such as pattern recognition, optimization, event classification, control and identification of nonlinear systems, and statistical analysis

21. I. What is Neuroinformatics? II.Neurocomputing ( 神经计算 )? III. Theoretical Neuroscience? IV.Computational Neuroscience ( 计算神经科学 )? V.Why we learn “Neuroinformatics” or “Computational Neuroscience” ? VI. Course structure

22. Theoretical Neuroscience = Computational and Mathematical Modeling of Neural Systems = Computational Neuroscience

23. What is I. Neuroinformatics? II.Neurocomputing ( 神经计算 )? III. Theoretical Neuroscience? IV.Computational Neuroscience ( 计算神经科学 )? V.Why we learn “Neuroinformatics” or “Computational Neuroscience” ? VI. Course structure

24. Computational neuroscience is a subfield of neuroscience that uses mathematical methods to simulate and understand the function of the nervous system (http://www.scholarpedia.org) Neuro- science Artifical Neural networks Dynamical system Computational neuroscience

25. Computational neuroscience A family member of brain science. Computer simulations of neurons and neural networks are complementary to traditional techniques in neuroscience Theoretical analysis and computational modeling are important tools for characterizing what nervous systems do, determining how they function, and understanding why they operate in particular ways Neuroscience encompasses approaches ranging from molecular and cellular studies to human psychophysics and psychology Theoretical neuroscience encourages cross-talk among these subdisciplines by constructing compact representations of what has been learned, building bridges between different levels of description, and identifying unifying concepts and principles

26. First neuron model － McCulloch & Pitts model (1943) (Bulletin of Mathematical Biophysics 5:115-133) Range: (0, 1) or (-1, 1) Time : t t+1

27. MP model simulates a few properties The unit has two states depending on the threshold: rest or activated Two types of synapses: inhibitory and excitatory The unit receives the linear sum of all the pre-synaptic inputs The introduction of time, mimicking the synaptic delay Advantage: Be able to perform logic operations Shortcoming: Too simple to model the real neuron

28. Goal 1.The first goal is to teach WHY mathematical and computational methods are important in understanding the structure, function and dynamics of neural organization 2. The second goal is to explain HOW neural phenomena occurring at different hierarchical levels can be described by proper mathematical models

29. What is I. Neuroinformatics? II.Neurocomputing ( 神经计算 )? III. Theoretical Neuroscience? IV.Computational Neuroscience ( 计算神经科学 )? V.Why we learn “Neuroinformatics” or “Computational Neuroscience” ? VI. Course structure

30. Why not go out for a walk? I mean the current neuroscience world is a little different from before For example: The Age of Brain Science （ Japan ） Understanding the Brain Protecting the Brain Creating the Brain Nurturing the Brain （ October 1997--- March 2008 ）

31. If you are a student majoring in experimental biology, － you may figure out your experimental problem or analyze results in a different way If you are a student having good mathematical or physical background, － ??? in future About mathematical and physical FORMULA: － High school knowledge is enough

32. Caveat Computational neuroscience is a huge and fast developing area This is only a very short course, and hopefully it can provide: － The basic concepts and methods of computational neuroscience research － Some brief introduction to neurobiological concepts and mathematical techniques. The techniques will be applied for describing the behavior of several brain regions

33. What is I. Neuroinformatics? II.Neurocomputing ( 神经计算 )? III. Theoretical Neuroscience? IV.Computational Neuroscience ( 计算神经科学 )? V.Why we learn “Neuroinformatics” or “Computational Neuroscience” ? VI. Course structure

34. Course Structure 0. Introduction: What is computational neuroscience, why is it urgently needed 1. Single neuron models 2. Neural network models 3.Neural Coding 4.Synaptic plasticity and learning 5.Hot points in brain modeling 6.Neurocomputing (by 史忠植老师 )

35. Recommended Readings 1.Thomas P. Trappenberg: Fundamentals of Computational Neuroscience. Oxford University Press, 2002 2.Peter Dayan & Larry F. Abbott: Theoretical Neuroscience. MIT Press, Cambridge. 2001 3. Koch C & Segev I: Methods in neuronal modeling: from ions to networks. MIT Press, Cambridge, 1998

36. 4. 汪云九等著，神经信息学. 北京 : 高等教育出版社. 2006 5. 郭爱克著, 计算神经科学. 上海科技教育出版社. 2000 6. 史忠植，智能科学. 清华大学出版社， 2006 7. Jeff Hawkins and Sandra Blakeslee, On Intelligence. Times Books 2004 人工智能的未来. 贺俊杰等译, 陕西科学技术出版社, 2006 8. F. Crick （汪云九等译）， ，湖南科学技术 出版社，长沙， 1998

37. 作业及思考题 1 神经信息学主要包括哪些内容？ 2 什么是计算神经科学？计算神经科学与神经计算的区别？ 3 第一个形式人工神经元模型是什么？模拟了神经元的哪 几个性质？