1. Principles of Immunology Autoimmunity 4/25/06

2. Organs Specific Autoimmune Diseases  Hashimoto’s thyroiditis DTH like response to thyroid Ags Ab to thyroglobulin Hypothyroidism  Pernicious anemia Ab to gastric parietal cells Interferes with vitamin update Reduced RBCs

3. Organs Specific Autoimmune Diseases  Goodpasture’s syndrome Ab to Ag on basement membranes C activation Glomerulonephritis, pulmonary disease  Type 1 diabetes Ab to beta cells of pancreas DTF reaction Cytokine induced damage

4. Organs Specific Autoimmune Diseases  Myasthenia gravis Ab to acetyl choline receptors Blocks muscle activation C activation and damage to muscle cells

5. Systemic Autoimmune Disease  SLE Ab to certain tissue antigens Vasculitis Diagnosis using anti nuclear antibodies  MS Reaction to myelin sheath Viral component?

6. Systemic Autoimmune Disease  Rheumatoid arthritis IgM which is anti IgG Immune complexes Chronic inflammation

7. Genetics vs. Environment  HLA type  Sequestered antigens

8. CD4 Cells and Autoimmune Disease  Transferable  Anti CD4 Ab protective

9. Mechanisms  Release or expression of Ags  Cross reacting Ags

10. Therapies  Cyclosporin  Interferes with T cell development  Anti-inflammatories