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Randomized Phase II Study of Whole-Brain Radiation Therapy with or without Concomitant Temozolomide for Brain Metastases from Breast Cancer K. I. CAO 1,

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Presentation on theme: "Randomized Phase II Study of Whole-Brain Radiation Therapy with or without Concomitant Temozolomide for Brain Metastases from Breast Cancer K. I. CAO 1,"— Presentation transcript:

1 Randomized Phase II Study of Whole-Brain Radiation Therapy with or without Concomitant Temozolomide for Brain Metastases from Breast Cancer K. I. CAO 1, N. LEBAS 1, S. GERBER 1, C. LEVY 2, A. FOURQUET 1, F. CAMPANA 1, R. LE SCODAN 3, B. DE LA LANDE 4, C. BOURGIER 5, J.-Y. PIERGA 1, A. GOBILLION 1, A. SAVIGNONI 1, Y. M KIROVA 1 1 INSTITUT CURIE, PARIS, FRANCE ²CENTRE FRANÇOIS BACLESSE, CAEN, FRANCE 3 CENTRE HOSPITALIER PRIVÉ SAINT-GRÉGOIRE, SAINT-GRÉGOIRE, FRANCE 4 INSTITUT CURIE, SAINT-CLOUD, FRANCE 5 INSTITUT GUSTAVE ROUSSY, VILLEJUIF, FRANCE NO DISCLOSURE

2 Main Results Primary end-point: ORR  WBRT + TMZ: 30% (n = 15)  WBRT: 36% (n = 18)  No complete response Survival  Median OS: 9.4 m WBRT + TMZ / 11.1 m WBRT  2 years – OS: 18 % (each arm)  Median PFS: 6.8 m WBRT + TMZ / 7.4 m WBRT

3 Discussion Strenghts  Prospective randomized study with long-term follow-up  Homogeneous study population (only primary breast cancer) Weaknesses  No QOL assessment  No molecular stratification  No MGMT status

4 Take home messages  WBRT combined with temozolomide did not improve brain control among patients with brain metastases from breast cancer.  WBRT remains a standard treatment in this population.  WBRT + TMZ in TNBC ? THANK YOU.

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