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A fast-evolving human NPAS3 enhancer gained reporter expression in the developing forebrain of transgenic mice by Gretel B. Kamm, Rodrigo López-Leal, Juan.

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Presentation on theme: "A fast-evolving human NPAS3 enhancer gained reporter expression in the developing forebrain of transgenic mice by Gretel B. Kamm, Rodrigo López-Leal, Juan."— Presentation transcript:

1 A fast-evolving human NPAS3 enhancer gained reporter expression in the developing forebrain of transgenic mice by Gretel B. Kamm, Rodrigo López-Leal, Juan R. Lorenzo, and Lucía F. Franchini Philosophical Transactions B Volume 368(1632):20130019 December 19, 2013 ©2013 by The Royal Society

2 Location of exapted repeats and HAEs at the NPAS3 locus in the human genome. Gretel B. Kamm et al. Phil. Trans. R. Soc. B 2013;368:20130019 ©2013 by The Royal Society

3 Comparative expression analysis of human, chimpanzee and mouse 2xHAR142 orthologue sequences in transgenic mice. Gretel B. Kamm et al. Phil. Trans. R. Soc. B 2013;368:20130019 ©2013 by The Royal Society

4 NPAS3 expression in the developing mouse brain. Gretel B. Kamm et al. Phil. Trans. R. Soc. B 2013;368:20130019 ©2013 by The Royal Society

5 β-Galactosidase expression pattern at E12.5 in different cellular types in the developing brain. Gretel B. Kamm et al. Phil. Trans. R. Soc. B 2013;368:20130019 ©2013 by The Royal Society


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