1. 1 Introduction and Welcome Joel Saltz MD, PhD Co-Director caGrid Knowledge Center caGrid Knowledge Center Workshop February 2011

2. caGrid Knowledge Center Design, development, use of Biomedical Informatics Middleware Internal and Collaborative testing, prototyping Example areas: methods to reduce introduction of errors in federated data sources, common data element representation and management, management and query of Pathology/Radiology annotation, markup data, semantically enhanced ETL 2

3. Broad Community Interaction Broad and Ongoing Interaction with application communities – examples: CTSA – multiple prototypes, SOA working group NCRI – conferences, caGrid based collaborations Cardiovascular Research Grid – middleware framework that incorporates caGrid components Minority Health Grid – Difficult to treat hypertension in young African American men - whole exome sequencing 3

4. Broad Community Interaction Radiation Therapy Oncology Group, Advanced Technology Consortium, Quantitative Imaging Network - caGrid data, metadata, service federation ACRIN – Support for management of imaging annotation, markup data In silico centers – Science driven by integration of Imaging, Pathology, “omic”, outcome data. Novartis – Use of caGrid components 4

5. caGrid Experience Panel this afternoon Wealth of experience here Panel this afternoon with UAB, Utah, Roswell Park, Chronic Lymphocytic Leukemia Research Consortium, CVRG, ACTSI and TRIAD Initial Questions : List three additions/modifications to caGrid that, if carried out, would have made your project easier to accomplish List three additions/modifications to caGrid that, if carried out, would have allowed you to make your project more effective If you had to redeploy your project without using caGrid, what software would you use and how would this alternate software stack impact your project. How can NCI and/or Grid KC better support caGrid 1.x? 5