3. Lancet 373:1765-72, 2009

4. Baseline Characteristics of Participants and Study Design of Clinical Trials to Compare Intensive glucose- lowering versus Standard Treatment Kay et al, Lancet 373:1765-72, 2009

5. Study Design of Clinical Trials to Compare Intensive glucose-lowering versus Standard Treatment Kay et al, Lancet 373:1765-72, 2009

6. Event Rates of Cardiovascular Outcomes of Intensive-Lowering versus Standard Treatments Kay et al, Lancet 373:1765-72, 2009

7. Probability of events of non-fatal myocardial infarction with intensive glucose-lowering vs. standard treatment Ray et al, Lancet 2009; 373: 1765–72

8. Probability of events of coronary heart disease with intensive glucose-lowering vs. standard treatment

9. Probability of events of stroke with intensive glucose- lowering versus standard treatment Ray et al, Lancet 2009; 373: 1765–72

10. Probability of events of all-cause mortality with intensive glucose-lowering versus standard treatment Ray et al, Lancet 2009; 373: 1765–72

11. Annals Internal Medicine 2009; 151: 394-403

12. Pooled relative risk and risk differences (per 1000 patients over 5 years of treatment) estimates of nonfatal MI, fatal MI, nonfatal stroke, fatal stroke, and PAD UKPDS 34 ACCORD ADVANCE VADT Kelly et al, Ann Inter Med 2009; 151: 394-403

13. Pooled relative risk and risk differences (per 1000 patients over 5 years of treatment) estimates of nonfatal MI, fatal MI, nonfatal stroke, fatal stroke, and PAD Kelly et al, Ann Inter Med 2009; 151: 394-403

14. Pooled relative risk and risk differences (per 1000 patients over 5 years of treatment) estimates of severe hypoglycemia Kelly et al, Ann Inter Med 2009; 151: 394-403

15. Summary of Meta-Analysis These 2 meta-analysis found that, compared with conventional control, intensive glucose control reduce the risk for cardiovascular disease (mostly nonfatal myocardial infarction) but not for cardiovascular death or all-cause mortality, and increased risk for severe hypoglycemia. Early trials suggested possible decreased risk for death with intensive control, whereas some more recent trials suggested possible increased risk for death with more stringent control.