1. ACRIN – Ten Excellent Years ACRIN RA Sessions-2009 1 - Specificity 0.00.20.40.60.81.0 0.0 0.2 0.4 0.6 0.8 1.0 Sensitivity

2. ACRIN Past and Future Origins of ACRIN ACRIN’s initial organization –Structure –People Accomplishments The Future

3. ACRIN: The Beginning 1997 – Dr. Robert Wittes convenes two meetings to discuss the “feasibility” of multi-center trials of imaging Growing importance of imaging to cancer care Imaging as a marker of treatment response Imaging to describe cancer biology

4. ACRIN: The Beginning 1997 – Inception of NCI DIP (later BIP, now CIP) Early 1998 – Issuance of RFA for a clinical trials “network” for imaging as it relates to cancer –Linked HQ and BC grants –Avoid the bureaucracy of established groups –Non-member

5. ACRIN: The Beginning 1998 – ACR asked that I apply on behalf of ACR –Recruit C. Gatsonis –C. Olson as support staff –Organization of individuals and sites Sept. 1998 – RFA awarded to ACRIN Sept. 1998-March 1999 – Development of early infrastructure –Staff –Electronic communications –Bylaws and procedures

6. ACRIN’s Mission Conduct clinical trials of imaging technologies to improve the length and quality of the lives of cancer patients.

7. ACRIN in the Beginning

9. Early ACRIN Needs What we had: –Passion about our mission –Good science –Growing interest from sites and researchers What we needed: –Quality management –Fiscal planning and direction –Improved reliability –Advocacy

10. If you try some time, You might find You get what you need. - The Rolling Stones

11. What We Needed

12. ACRIN Accomplishments 30 multi-center trials including signal trials that have changed cancer surveillance and care –High profile imaging screening trials –Trials of all applications of imaging ScreeningScreening DiagnosisStagingDiagnosisStaging TreatmentTreatment ResponseMarkerResponseMarker

14. ACRIN Accomplishments A network of more than 200 qualified sites Hundreds of researchers –Radiologists and other clinicians –Site RAs –Statisticians and methodologists –Patient advocates –ACR staff

15. ACRIN Accomplishments Cadre of research associates to improve research in radiology departments –Active in all ACRIN activities –Education and training programs –Enhanced effectiveness for radiology research in the future

16. Research Associates

17. ACRIN Accomplishments Patient Advocate Committee - advocacy participation and community outreach for imaging trials –Project IMPACT –Participation in all ACRIN trials and committees –Educate key decision makers of the importance of imaging to research and care

18. Patient Advocates

19. Well-Trained Clinical Researchers “Laboratory” for research training and accomplishment –Further development of established researchers –Exposure and training for new clinical researchers

21. ACRIN Accomplishments All electronic network with infrastructure, policies, and procedures Data archive for secondary research and new product development Dissemination of standards for conducting imaging trials Improved awareness of the importance of imaging to cancer research and care

22. ACRIN Accomplishments Patient Advocate Groups Treatment Cooperative Groups Industry/Foundations Academia Government SPOREs Clinics Community Hospitals and Clinics Cancer Centers ACRIN

23. The Future 1999-2003: Target of opportunity 2004-2007: Objective-driven 2008-2013: Greater sophistication –Consistent with the progression toward molecular medicine and individualized cancer care Targeted surveillance of at-risk populations Characterization of cancer to drive targeted therapies Predictive and prognostic biomarkers of cancer treatment

24. ACRIN Diversification Achieve funding that allows for trials other than cancer – CV and CNS to start –ACRIN Fund for Innovative Imaging to diversify outside of cancer Springboard to other funding –NHLBI –NINDS –ACR Image Metrix profits –PA-CURE and foundations

25. When a blind beetle crawls over the surface of a curved branch, it doesn’t notice that the track it has covered is indeed curved. - Albert Einstein