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Author(s): Brenda Gunderson, Ph.D., 2011 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

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Presentation on theme: "Author(s): Brenda Gunderson, Ph.D., 2011 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share."— Presentation transcript:

1 Author(s): Brenda Gunderson, Ph.D., 2011 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share Alike 3.0 License: http://creativecommons.org/licenses/by-nc-sa/3.0/ We have reviewed this material in accordance with U.S. Copyright Law and have tried to maximize your ability to use, share, and adapt it. The citation key on the following slide provides information about how you may share and adapt this material. Copyright holders of content included in this material should contact open.michigan@umich.edu with any questions, corrections, or clarification regarding the use of content. For more information about how to cite these materials visit http://open.umich.edu/education/about/terms-of-use. Any medical information in this material is intended to inform and educate and is not a tool for self-diagnosis or a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional. Please speak to your physician if you have questions about your medical condition. Viewer discretion is advised: Some medical content is graphic and may not be suitable for all viewers.

2 Attribution Key for more information see: http://open.umich.edu/wiki/AttributionPolicy Use + Share + Adapt Make Your Own Assessment Creative Commons – Attribution License Creative Commons – Attribution Share Alike License Creative Commons – Attribution Noncommercial License Creative Commons – Attribution Noncommercial Share Alike License GNU – Free Documentation License Creative Commons – Zero Waiver Public Domain – Ineligible: Works that are ineligible for copyright protection in the U.S. (17 USC § 102(b)) *laws in your jurisdiction may differ Public Domain – Expired: Works that are no longer protected due to an expired copyright term. Public Domain – Government: Works that are produced by the U.S. Government. (17 USC § 105) Public Domain – Self Dedicated: Works that a copyright holder has dedicated to the public domain. Fair Use: Use of works that is determined to be Fair consistent with the U.S. Copyright Act. (17 USC § 107) *laws in your jurisdiction may differ Our determination DOES NOT mean that all uses of this 3rd-party content are Fair Uses and we DO NOT guarantee that your use of the content is Fair. To use this content you should do your own independent analysis to determine whether or not your use will be Fair. { Content the copyright holder, author, or law permits you to use, share and adapt. } { Content Open.Michigan believes can be used, shared, and adapted because it is ineligible for copyright. } { Content Open.Michigan has used under a Fair Use determination. }

3 Test of Homogeneity Summary page 214 From Utts, Jessica M. and Robert F. Heckard. Mind on Statistics, Fourth Edition. 2012. Used with permission.

4 Try it! What is your Decision? Chi-square test of homogeneity: 3 populations and 4 possible values of discrete characteristic. If H 0 is true, that is, the distribution for the response is the same for all 3 populations, what is the expected value of the test statistic?

5 Try it! Treatment for Shingles pg 215 Headline “For adults, chicken pox vaccine may stop shingles”. Clinical trial conducted: 420 subjects were randomly assigned to receive chicken pox vaccine or a placebo vaccine. Side effects: swelling and rash around injection site.

6 Treatment for Shingles a.Name of test for assessing if the distribution of swelling status is the same for the two treatment populations.

7 Treatment for Shingles b.Based on data, among those chicken pox vaccinated subjects, what percent had major swelling around the injection site?

8 Treatment for Shingles c.Based on data, among those placebo vaccinated subjects, what percent had major swelling around the injection site?

9 Treatment for Shingles d.Assuming distribution of swelling status is same for two trt populations, how many chicken pox vaccinated subjects would you expect to have major swelling around site?

10 Treatment for Shingles e.Use a level of 0.05 to assess if the distribution of swelling status is the same for the two treatment populations. Test Statistic Value: _________ p-value: __________ Think about this p-value, your decision and get ready to click in for the conclusion…

11 Thus, the distribution of swelling status __________ appears to be the same for the two treatment populations. A) does B) does not

12 Test of Independence page 216 to assess if 2 discrete (categorical) variables are independent for a population.  1 population  1 random sample  2 variables measured, both categorical or discrete

13 Smoking and Hypertension Scenario:One population of interest – factory workers. Question: Is there a relationship between smoking habits and whether or not a factory worker experiences hypertension. Data: 1 random sample of 180 factory workers, measured: X = hypertension status (yes or no) Y = smoking habit (non, moderate, heavy) Find row and column totals … Note: neither row nor column totals known before measuring variables. Y=SmokingHabit X=NonModHeavy Hyper Yes213630 Status No482619

14 Smoking & Hypertension Null Hypothesis Scenario:1 population of factory workers Question: Is there an association between smoking habit and hypertension status? H 0 :There is no association between smoking habit and hypertension status for population of factory workers. We say it in words (following math way from page 216)… P( heavy smoker and have hypertension) = P( heavy smoker) P( have hypertension)

15 Observed and Expected Counts Cross-Product Rule Expected Counts Y=SmokingHabit X=NonModHeavy Hyper Yes21 ( )36 ( )30 ( )87 Status No48 ( )26 ( )19 ( )93 696249180

16 Smoking & Hypertension Test Statistic Y=SmokingHabit X=NonModHeavy Hyper Yes21 ( 33.35 )36 ( 29.97 )30 ( 23.68 )87 Status No48 ( 35.65 )26 ( 32.03 )19 ( 25.32 )93 696249180

17 Smoking & Hypertension Example Do you think the value of ____________ is large enough to reject H 0 ? If H 0 is true, then X 2 has the  2 distribution with df = _________________ Use our frame of reference first … then find the p-value

18 Using our Frame of Reference So, if H 0 true, we would expect our X 2 test statistic to be about ______ give or take about ___________. About how many standard deviations is the observed X 2 value of 14.5 from the expected value under H 0 ?

19 p-value for Smoking & Hypertension Example Observed value = __________ df = ___________ Find the p-value using your Table A.5 Keep the p-value in mind and be ready to click in answers to whether statistically significant and the conclusion.

20 A = Yes or B = No Are the results statistically significant at the 1% level?

21 Which is the appropriate conclusion? A) There is an association between smoking and hypertension for this population of workers represented by this sample. B) There is no association between smoking and hypertension for this population of workers represented by this sample.

22 Relationship between Age Group and Appearance Satisfaction Are you satisfied with your overall appearance? Random sample of 150 women were surveyed.  Answer (Yes or No) recorded and  Age category (1 = under 30, 2 = 30 to 50, and 3 = over 50). Solutions will be posted on Ctools …

23 Yellow Card


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