1. Fascinoma Rounds Group B streptococcus in ascitic fluid October 26th, 2005 Sharmistha Mishra, Vanessa Allen, And with great thanks to Subash Mohan

2. Case #3: Group B streptococcus in ascitic fluid How common is GBS in peritonitis? What are the clinical implications of GBS peritonitis?

3. Risk Factors Cases associated with continuous ambulatory peritoneal dialysis (CAPD) –Colonization of genital and anal tract –Seven cases have been described previously and all had a very severe course Liakopoulos V. et al. Clinical Nephrology. 62(5):391-6, 2004 Nov. Scanziani R. et al. Nephrology Dialysis Transplantation. 14(9):2222-4, 1999 Sep.

4. Group B Strep Infection Seen in neonates and peripartum women In non -pregnant adults (2/3rds of cases) –DM, Liver failure, RF, malignancy, AIDS –Most often manifested as skin or soft-tissue infection bacteremia genitourinary infection Pneumonia Peritonitis –5-10% caused by strep spp. –Most common is viridans streptococcus

5. Pathophysiology From GU source –10- 30% of pregnant women colonized –Peritonitis secondary Severity of disease –Secondary bacteremia Farley MM, et al. N Engl J Med. 1993;328:1807-1811.