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Department of Biopharmaceutics and Pharmacodynamics Faculty of Pharmacy, Medical University of Gdańsk Head: Prof. Roman Kaliszan, Ph.D., D.Sc. Corresponding.

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Presentation on theme: "Department of Biopharmaceutics and Pharmacodynamics Faculty of Pharmacy, Medical University of Gdańsk Head: Prof. Roman Kaliszan, Ph.D., D.Sc. Corresponding."— Presentation transcript:

1 Department of Biopharmaceutics and Pharmacodynamics Faculty of Pharmacy, Medical University of Gdańsk Head: Prof. Roman Kaliszan, Ph.D., D.Sc. Corresponding Member of the Polish Academy of Sciences Prof. Antoni Nasal, Ph.D., Barbara Damasiewicz, Ph.D., Michał Markuszewski, Ph.D., Aleksandra Radwańska, Ph.D., Danuta Siluk, Ph.D., Tomasz Bączek, Ph.D., Teresa Frąckowiak, Ph.D., Anna Wojdełko, M.Sc., Michał Marszałł, M.Sc., Paweł Wiczling, M.Sc., Aleksandra Dąbrowska, Ing., Janina Kozłów Address: Gen. J. Hallera 107, 80-416 Gdańsk Tel.: ++48 58 3493260 Fax: ++48 58 3493262 e-mail: roman.kaliszan@amg.gda.pl

2 Wydział Chemii Uniwersytetu Gdańskiego Instytut Farmaceutyczny w Warszawie Instytut Leków w Warszawie Zakład Chemii Środowiska Wydziału Chemii Uniwersytetu Mikołaja Kopernika w Toruniu Instytut Rozrodu Zwierząt i Badań Żywności PAN w Olsztynie Department of Chemistry, University of Edinburgh Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Frankfurt am Main Forschungsinstitut für experimentelle Biologie und Medizin, Borstel Department of Chemistry, Rutgers University, New Brunswick Department of Oncology, McGill University, Montreal Department of Chemistry, State University of New York in Binghamton Institut für Organische Chemie, Abteilung Bioorganische Chemie, Universität Bremen Department of Chemistry, University College London, London Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest Laboratory of Instrumental Analysis, University of Technology, Eindhoven LC Resources Inc., Walnut Creek, CA, USA School of Materials Science, Toyohashi University of Technology, Department of Polymer Science and Engineering, Kyoto Institute of Technology Faculty of Science, Himeji Institute of Technology COLLABORATORS

3 PUBLICATION RECORDS Books10 Review Articles14 Original Reports160 Full Papers in Symposium Proceedings30 Patents6 Symposium Abstracts210 Published book reviews, popularization of science, etc.50 Σ 480 Σ IF>250 Total number of citations 3.000

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5 MEMBERSHIP OF EDITORIAL (ADVISORY) BOARDS - Solubility Data Series (1985 - 1992) - Quantitative Structure-Activity Relationships (1988 - 1997) -Biomedical Chromatography (since 1998) - Journal of Chromatographic Science (since 2000) - Journal of Separation Science (since 2001) - Journal of Pharmaceutical and Biomedical Analysis (since 2001) - Acta Chromatographica (since 1995) -Acta Poloniae Pharmaceutica - Drug Research (since 1997) - Annales Universitatis Mariae Curie-Skłodowska -Annales Academiae Medicae Gedanensis -Farmacja Polska - Gazeta AMG - Służba Zdrowia - Wiadomości Farmaceutyczne About 400 reviews of manuscripts presented to some 30 international journals

6 CHOICE OF STRUCTURE Example: S = 20; N = 8 X = S N = X = 20 8 = 25 600 000 000 N - number of substitution sites S - number of substituents CA describes 12 000 000 compounds

7 Numerical descriptors of solute structures Chromatographic retention parameters Computerized statistical data processing QSRR Identification of informative descriptors Determination of molecular separation mechanism Quantitative comparison of columns Retention prediction Determination of complex physicochemical properties Evaluation of relative biological activity

8 WATER I pH 1 Drug molecules I : neutral I + ionized I WATER II pH 1I Drug molecules II : neutral II + ionized II Example: Kanamycin: pK a = 7.2 Milk: pH I = 6.4 Blood: pH II = 7.4 Lipid Drug: Water/lipid partition (log P, log k w ); Degree of ionization (pK a )

9 IMMOBILIZED ARTIFICIAL MEMBRANES

10 CHROMATOGRAPHIC MODELING OF DRUG-PROTEIN INTERACTIONS (HSA, AGP, Melanin, Keratin, Collagen) STERIC RESTRICTION HYDROPHOBIC REGION + ANIONIC REGION

11 FUTURE PROJECTS AND GOALS - pH-Gradient HPLC: a new method of chromatographic analysis of bioanalytes - Metabolomics: metabolite profile differentiation using LC/CE/MS and bioinformatics -Analytical separation-identification platform LC-MC for the analysis of proteomes - Relationship between the GPIIIa gene A1/A2 polymorphism and blood platelet response to aggregation agonists among the North Poland population

12 SELECTED RECENT PUBLICATIONS R. Kaliszan: "Quantitative Structure-Retention Relationships (QSRR) in Chromatography", In Encyclopedia of Separation Science, Vol III, I.D. Wilson (Ed.), Academic Press, San Diego, 2000, pp. 4063-4075 D. Siluk, R. Kaliszan, P. Haber, J. Petrusewicz, Z. Brzozowski, G. Sut, Antiaggregatory activity of hypoglycaemic sulphonylureas, Diabetologia 45, 1034-1037 (2002) R. Kaliszan, P. Haber, T. Bączek, D. Siluk, K. Valko, Lipophilicity and pK a estimates from gradient high-performance liquid chromatography, J. Chromatogr. A 965, 117-127 (2002) M. Markuszewski, R. Kaliszan, Quantitative structure-retention relationships in affinity high- performance liquid chromatography, J. Chromatogr. B 768, 55-66 (2002) A. Nasal, D. Siluk, R. Kaliszan, Chromatographic retention parameters in medicinal chemistry and molecular pharmacology, Curr. Med. Chem. 10, 381-426 (2003) M.J. Markuszewski, P. Britz-McKibbin, S. Terabe, K. Matsuda, T. Nishioka, Determination of pyridine and adenine nucleotide metabolites in Bacillus subtilis cell extract by sweeping borate complexation capillary electrophoresis, J. Chromatogr. A 989, 293-301 (2003) T. Bączek, R. Kaliszan, Predictive approaches to gradient retention based on analyte structural descriptors from calculation chemistry, J. Chromatogr. A 987, 29-37 (2003)


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