1. Ashish Sharma, Tony Pan, Barla Cambazoglu, Joel Saltz Ohio State University, Columbus, OH (ashish, tpan, barla)@bmi.osu.edu October 10, 2007 caBIG In Vivo Imaging Middleware

2. For more information: http://www.virtualpacs.org Overview Background on In Vivo Imaging Middleware (IVIM) Recent developments/enhancements Federated query processing infrastructure Enhanced Security Infrastructure Extensions in Pathology (caMicroscope) Grid Enabled CERR (Computational Environment for Radiotheraphy Research) XML Data Service caGrid Data Service for Annotation and Image Markup (AIM) Migration and upgrade of IVI Phase 1 Ongoing / Future work

3. For more information: http://www.virtualpacs.org In Vivo Imaging Middleware Purpose: create the core infrastructure for Grid enabling imaging applications Services, tools, and APIs DICOM–Grid interoperability High-performance data transfer Development/deployment tools for imaging-based grid services Security Layered on the caGrid toolkit

4. For more information: http://www.virtualpacs.org Core Capabilities DICOM data service Provides a two way interface between caGrid and DICOM entities Supports DICOM C_FIND, C_GET, C_MOVE, and C_STORE commands Bulk data transport support VirtualPACS Provide DICOM messaging interface to caGrid DICOM data services Federate multiple grid services Generic image data service Provides a two-way interface between caGrid and images on a file system Can be extended to use a database that contains image metadata Bulk data transport support

5. For more information: http://www.virtualpacs.org Core Capabilities Bulk data transport GridFTP is the grid service used for transfer of data Supports image retrieval and submission Data generated dynamically based on grid service requests WS enumeration-based data transfer Security User-level authorization Data-level authorization Transport-level authorization Development tools SDK: Introduce extensions to facilitate creation of services IVIWizard: Tool to facilitate configuration and deployment of DICOM Data Services

6. For more information: http://www.virtualpacs.org New Developments/Enhancements New developments Federated query processing infrastructure Enhancements to Security Infrastructure Grid Enablement of CERR Middleware extensions to support pathology (caMicroscope) XML Data Service Data services in the CardioVascular Research Grid AIM Data Service Migrate to NCIA v3.0 DICOM model caGrid 1.1 upgrade

7. For more information: http://www.virtualpacs.org Federated Query Processing Sample queries “Find all DICOM images where the RECIST length criterion is greater than a certain value” “Find all AIM annotations related to a specified set of patients” Leveraging caGrid FQP infrastructure Mechanisms to perform basic distributed aggregations and joins of queries over multiple data services Distributed caGrid Query Language (DCQL) Components Federated query processing service, and the query engine Federated result service caGrid data services which provide the data

8. For more information: http://www.virtualpacs.org FQP Sequence Diagram

9. For more information: http://www.virtualpacs.org FQP Client

10. For more information: http://www.virtualpacs.org AIM Data Service caGrid data service for storing AIM annotations Components XML Backend (Berkeley DB XML database) Grid data service Wrapper CQL to XPath translation and query Introduce extension to build data services using XML schema Can be generated from data model in XMI Can be generated from data model in caDSR and GME Can be linked to caDSR

11. For more information: http://www.virtualpacs.org Security in the Imaging World Encryption Authentication Authorization Bulk Data Transport Authorization Out-of-band Harmonization with caGrid security Infrastructure

12. For more information: http://www.virtualpacs.org Service and Operation Security caGrid provides essential services Encryption and signature for session and message Authentication with Dorian Role/user-based authorization with GridGrouper At service level At operation level User “role” defined a priori in GridGrouper Web service container Transport-level security (HTTPS) Encryption and signature

13. For more information: http://www.virtualpacs.org Role and User Management Manage user and groups Leverages caGrid GridGrouper group management interface Allow creation of user groups and management of user memberships

14. For more information: http://www.virtualpacs.org Data-Level Authorization PACS may contain data for multiple trials Read/write access to data instance Based on user identity and groups the user belong to Authorization information stored in GridGrouper as data permission groups Data permission groups match PACS data hierarchy Data permission groups contain user groups, and indirectly users, as members DICOMDataService checks GridGrouper Data Permission Groups for authorization before and after PACS query

15. For more information: http://www.virtualpacs.org Role-based Security Infrastructure Integrate existing authorization mechanisms May require application specific implementation NCIA authorization implementation Utilizes CSM protection elements and user groups Authorize based on CSM database table Validate and performance optimization Expanded testing caGrid 1.1

16. For more information: http://www.virtualpacs.org Slide from Walter Bosch caGrid Enabled CERR

17. For more information: http://www.virtualpacs.org gridEnabled CERR Computational Environment for Radiotherapy Research Radiotherapy treatment planning software Tools for review and analysis Tools for dosimetry caGrid enabled data collection in cooperative groups Data service for DICOM RT Objects Data service for CERR Objects Grid Enabled CERR Client written in MATLAB CERR service capable of streaming to CERR Client

18. For more information: http://www.virtualpacs.org CERR Data Service A caGrid data service for storing CERR objects Capabilities Query Submit Retrieve Components Berkeley DB XML database Bulk data transport Will be combined with the DICOM data service to create workflows for radiation treatment planning Invoke MATLAB scripts on the remote end

19. For more information: http://www.virtualpacs.org caMicroscope Service-based infrastructure Multiple, geographically distributed scientists and developers access a common image data repository Shared code repository allowing reusability of the developed codes Remote job execution Remote image visualization Multi-processor backend Fast parallel processing of images Specifically designed for very large-scale image processing Pipelined processing capabilities

20. For more information: http://www.virtualpacs.org caMicroscope caMicroscope data service Based on the caGrid 1.1 middleware Using Introduce service development toolkit Provided operations on images/algorithms Query CQL Retrieve/Upload Bulk data transfer GridFTP View Aperio libraries Parallel execution of MATLAB code on high-end machines Out-of-core virtual microscope MATLAB

21. For more information: http://www.virtualpacs.org General System Infrastructure

22. For more information: http://www.virtualpacs.org Viewing and Execution Client

23. For more information: http://www.virtualpacs.org Architecture for Parallel MATLAB Processing

24. For more information: http://www.virtualpacs.org XML Data Service Extensions to caGrid A general purpose, non-specific XML database backed Data Service Supports XPath query Integrates CQL-XPath Conversion in a generic XPathCQLQueryProcessor Coupled to an Xpath aware XML Database such as eXist CQL to Xpath query translation maps all CQL constructs to a subset of Xpath constructs Given an XSD (and in the future, a model), can create and stage an XML Data Service rapidly

25. For more information: http://www.virtualpacs.org XML Introduce Extension (Demo)

26. For more information: http://www.virtualpacs.org Migration to NCIA v3.0, caGrid 1.1 Migrate to NCIA v3.0 DICOM model iviCore Middleware DICOM Data Service VirtualPACS IVI Software Development and Deployment Toolkit Upgrade to caGrid 1.1 iviCore Middleware, VirtualPACS and the different grid services Security Infrastructure IVI Software Development and Deployment Toolkit