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A 50 year old man with progressive tetraparesis and blindness Teaching NeuroImages Neurology Resident and Fellow Section © 2013 American Academy of Neurology.

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Presentation on theme: "A 50 year old man with progressive tetraparesis and blindness Teaching NeuroImages Neurology Resident and Fellow Section © 2013 American Academy of Neurology."— Presentation transcript:

1 A 50 year old man with progressive tetraparesis and blindness Teaching NeuroImages Neurology Resident and Fellow Section © 2013 American Academy of Neurology

2 Vignette 50 year old man Progressive tetraparesis Loss of vision CSF studies showing mild pleocytosis, very high protein, and low to normal glucose CSF cultures, cytological examinations, and flow cytometry were normal Weijenberg et al.

3 Imaging Weijenberg et al.

4 FDG-PET-imaging in primary diffuse leptomeningeal gliomatosis FDG-PET showed increased uptake in the spinal cord and brain consistent with primary diffuse leptomeningeal gliomatosis, leptomeningeal carcinomatosis/lymphoma or isolated CNS-infection. A temporal leptomeningeal-cortical biopsy confirmed primary diffuse leptomeningeal gliomatosis (PDGL). Although rarely performed, FDG-PET in PDGL characteristically demonstrates increased uptake isolated to the CNS and may contribute to the diagnosis PDGL. Weijenberg et al.

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