1. Hypothalamus Clark Mannas and Harrison Cardwell 4B

2.  The hypothalamus is located in the brain  It is central, under the thalamus  Some of the main functions involve body temperature control and the linking of the nervous system to the endocrine system with the pituitary gland.  The hypothalamus has many distinct nuclei  It is highly connected with other parts of the brain and nervous system Overview

3.  Gonadotropin (releasing hormone – GnRH) Controls follicle stimulating hormone (FSH) and luteinizing hormone (LH), stimulates testes and ovaries  Thyrotropin (releasing hormone – TRH) Promotes thryoid stimulating hormone (TSH) and prolactin (PRL) secretion  Corticotropin (releasing hormone – CRH) Promotes growth hormone (GH) secretion  Somatostatin Inhibits GH and TSH secretion  Antidiuretic Hormone (ADH) Prevents dehydration through reduced urine volume and subsequent greater water retention  Oxytocin (OT) Responsible for feelings of lust and love, is especially prevalent in sexual intercourse Hormone Production

4. Regulation  The Hypothalamic-Pituitary Axis is unique in its self-regulation; the hormones of one (for instance, cortisol, an inhibitor for the hypothalamus) will bind to the other, stoppping further production  This perfect, symbiotic relationship is referred to as negative feedback inhibition

5. Hypothalamic disease  Hypothalamic disease can be caused by eating disorders or malnutrition, as well as genetic disorders or trauma  This can interfere with hormone production as well as the maintenance of homeostasis  The vast area of effect yields symptoms ranging from vision loss to tumors to impotence  As far as treatment, the tumors can be dealt with through surgery or radiation, where the hormone deficiencies can be handled with a replacement of those that are lacking

6. Sources  http://quizlet.com/5823150/eight-hormones-produced- in-the-hypothalamus-flash-cards/ http://quizlet.com/5823150/eight-hormones-produced- in-the-hypothalamus-flash-cards/  http://www.psychologytoday.com/basics/oxytocin http://www.psychologytoday.com/basics/oxytocin  http://www.nlm.nih.gov/medlineplus/ency/article/00120 2.htm http://www.nlm.nih.gov/medlineplus/ency/article/00120 2.htm  http://courses.washington.edu/conj/bess/feedback/ne wfeedback.html http://courses.washington.edu/conj/bess/feedback/ne wfeedback.html