1. TRANSPLANTATION CHAPTER 8 ANZDATA Registry Annual Report 2013

2. Figure 8.1 Number of Kidney Transplant Operations Total (Living Donors) Year Australia New Zealand 1st2nd3rd4th5thTotal 1st2nd3rd4thTotal 1963510006 (0) 00000 1964200002 (0) 00000 196512110014 (3) 10001 (1) 196618200020 (5) 1030013 (0) 196769200071 (2) 1841023 (1) 19689710000107 (0) 1740021 (2) 196914912000161 (0) 3950044 (0) 197016812200182 (1) 2131025 (0) 197120722100230 (1) 2660032 (1) 197218316000199 (2) 4380051 (1) 197321330100244 (7) 50102062 (0) 197422435400263 (6) 3551041 (3) 197527129310304 (7) 61130074 (2) 197622341400268 (10) 38131052 (1) 197726557400326 (16) 46102058 (4) 197826943200314 (17) 43113057 (11) 197929335500333 (34) 61133279 (16) 198028763900359 (36) 57134074 (18) 198130658910374 (35) 5181060 (10) 198232172600399 (53) 48170065 (8) 1983272631020347 (48) 69254098 (11) 1984362721010445 (48) 63110074 (16) 1985318791710415 (36) 60253088 (6) 198636663720438 (32) 791961105 (13) 1987310582130392 (40) 57174179 (20) 1988391621021466 (46) 61116078 (8) 1989433461020491 (48) 71111083 (12) 199038745920443 (59) 861420102 (23) 1991386701130470 (78) 62104177 (13) 1992404571330477 (70) 105550115 (17) 199338563641459 (66) 68132083 (20) 1994384411221440 (103) 70111183 (20) 1995371601100442 (94) 8473094 (24) 199641650900475 (115) 8871096 (26) 199744751610505 (147) 1011010112 (31) 1998443621120518 (161) 951010106 (31) 199940343900455 (169) 971140112 (42) 200047647710531 (181) 911320106 (31) 200148845620541 (213) 101900110 (43) 200253760520604 (230) 1031220117 (48) 2003472601010543 (218) 941340111 (44) 2004583531130650 (244) 98700105 (48) 2005539671520623 (246) 8750193 (46) 2006549701750641 (273) 8082090 (49) 2007527751102615 (271) 112920123 (58) 2008708841650813 (354) 1111010122 (69) 2009674881100773 (327) 1091200121 (67) 2010744831810846 (296) 104510110 (60) 2011744681030825 (255) 110710118 (57) 2012747801512845 (238) 99900108 (54)

3. ANZDATA Registry Annual Report 2013 Figure 8.2

4. ANZDATA Registry Annual Report 2013 Figure 8.3

5. ANZDATA Registry Annual Report 2013 Figure 8.4a

6. ANZDATA Registry Annual Report 2013 Figure 8.4b

7. ANZDATA Registry Annual Report 2013 Figure 8.5

8. ANZDATA Registry Annual Report 2013 Figure 8.6

9. ANZDATA Registry Annual Report 2013 Figure 8.7 * Pre-emptive transplant patients included

10. ANZDATA Registry Annual Report 2013 Figure 8.8 * Pre-emptive transplant patients included

11. ANZDATA Registry Annual Report 2013 Figure 8.9 Graft Number and Age of Patients Transplanted 2012 Donor Source Graft No. Age Groups Total 00-0405-1415-2425-3435-4445-5455-6465-7475-84 Australia Deceased 1 26166685143155582533 2 00441225142061 3 00203510011 Living Donor 4 0000110002 1 5132923414043182214 2 00266212019 3 0000130004 4 0000010001 Total 7195399149218214804843 New Zealand Deceased 1 1030105916750 2 2000003104 Living Donor 1 107238817449 2 2001112005 Total 6010314 223411108

12. ANZDATA Registry Annual Report 2013 Figure 8.10

13. ANZDATA Registry Annual Report 2013 Figure 8.11

14. ANZDATA Registry Annual Report 2013 Figure 8.12 Australia Transplantation Rate - Age Group 15-64 years 2003 - 2012 Year Caucasian Aboriginal and Torres St. Islanders All Patients TxDialysedRate TxDialysedRate TxDialysedRate 2003 414379010.9% 127831.5% 47852519.1% 2004 491387512.7% 258562.9% 581543810.7% 2005 460404011.4% 209302.2% 54857169.6% 2006 481424111.3% 279892.7% 57960399.6% 2007 471438010.8% 1710651.6% 55763318.8% 2008 602448813.4% 2911762.5% 724663210.9% 2009 574449712.8% 2311991.9% 687671910.2% 2010 607443813.7% 2712152.2% 734672710.9% 2011 550447412.3% 2512742.0% 695687910.1% 2012 585451213.0% 1913371.4% 734708210.4%

15. ANZDATA Registry Annual Report 2013 Figure 8.13 New Zealand Transplantation Rate - Age Group 15-64 years 2003 - 2012 Year CaucasianMaoriPacific PeopleAll Patients TxDialysedRateTx Dialyse d RateTx Dialyse d RateTx Dialyse d Rate 20036454511.7%165313.0%132714.8%10114427.0% 20046554212.0%105581.8%122854.2%9614836.5% 20057356812.9%35630.5%33031.0%8215235.4% 20065956710.4%96061.5%53221.6%8015995.0% 20078257614.2%156162.4%63441.7%11116486.7% 20088458614.3%126201.9%93762.4%11216996.6% 20097759912.9%136372.0%64051.5%10117835.7% 20106259310.5%176622.6%84451.8%9518605.1% 20116760611.1%186522.8%74671.5%10418875.5% 20126060110.0%126721.8%74881.4%8819424.5%

16. ANZDATA Registry Annual Report 2013 Figure 8.14 New Transplanted Patients 2008 - 2012 Related to Ethnicity Race20082009201020112012 Australia 813 (100.0%)773 (100.0%)846 (100.0%)825 (100.0%)845 (100.0%) Caucasian 675 (83.0%)651 (84.2%)706 (83.5%)657 (79.6%)669 (79.2%) Aboriginal/Torres St. Islanders 31 (3.8%)24 (3.1%)28 (3.3%)28 (3.4%)20 (2.4%) Asian 83 (10.2%)75 (9.7%)83 (9.8%)97 (11.8%)88 (10.4%) Other 24 (3.0%)23 (3.0%)29 (3.4%)43 (5.2%)68 (8.0%) New Zealand 122 (100.0%)121 (100.0%)110 (100.0%)118 (100.0%)108 (100.0%) Caucasian93 (76.2%)91 (75.2%)71 (64.5%)77 (65.3%)74 (68.5%) Asian7 (5.7%)5 (4.1%)8 (7.3%)11 (9.3%)11 (10.2%) Maori12 (9.8%)19 (15.7%)20 (18.2%)20 (16.9%)15 (13.9%) Pacific10 (8.2%)6 (5.0%)9 (8.2%)9 (7.6%)7 (6.5%) Other--2 (1.8%)1 (0.8%)1 (0.9%)

17. ANZDATA Registry Annual Report 2013 Figure 8.15 Transplants in each Region 2008 - 2012 Number of Operations (per Million Population per year) State20072008200920102011 Queensland 136 (32)140 (32)137 (31)155 (35)159 (35) New South Wales / ACT * 243 (33)238 (32)265 (35)232 (31)247 (32) Victoria / Tasmania * 246 (42)233 (39)285 (48)278 (46)268 (44) South Australia / NT * 110 (60)83 (45)82 (44)74 (40)88 (47) Western Australia 78 (36)79 (35)77 (34)86 (37)83 (34) Australia 813 (38)773 (35)846 (38)825 (37)845 (37) * For calculation of population related totals, the populations of these States were summed

18. ANZDATA Registry Annual Report 2013 Figure 8.16

19. ANZDATA Registry Annual Report 2013 Figure 8.17 NSW population excludes residents of the Southern Area Health Service ACT population includes residents of the Southern Area Health Service Medical services in the ACT service the Southern Area Region

20. ANZDATA Registry Annual Report 2013 Figure 8.18 Summary of Kidney Transplantation Australia 1963 - 2012 PerformedFunctioning* Deceased Donor First 133865073 Second 1997610 Third 326105 Fourth 4814 Fifth 62 Total 157635804 Living Donor First 44623023 Second 409251 Third 5944 Fourth 107 Fifth 10 Total 49413325 Total 207049129 * Lost to follow up not included

21. ANZDATA Registry Annual Report 2013 Figure 8.18 Summary of Kidney Transplantation Australia 1963 - 2012 Graft No.PerformedFunctioning* Deceased Donor First 133865132 Second 1997615 Third 326105 Fourth 4814 Fifth 62 Total 157635868 Living Donor First 44623121 Second 409262 Third 5944 Fourth 108 Fifth 10 Total 49413435 Unknown First 015 Second 02 Total 207049320 * Lost to follow up not included

22. ANZDATA Registry Annual Report 2013 Figure 8.19 Summary of Kidney Transplantation New Zealand 1965 - 2012 PerformedFunctioning* Deceased Donor First 2282748 Second 40078 Third 7618 Fourth 70 Total 2765844 Living Donor First 998626 Second 8248 Third 64 Total 1086678 UnknownFirst 02 Total 38511524 * Lost to follow up not included

23. ANZDATA Registry Annual Report 2013 Figure 8.20 Functioning Transplants 2003 - 2012 Transplanting Region, Australia and New Zealand (Number Per Million Population) YearQLD NSW/ACT * VIC/Tas *SA/NT *WA AustraliaNZ 20031243 (326)1976 (282)1593 (295)726 (419)551 (282)6089 (306)1164 (289) 20041289 (330)2077 (295)1671 (306)773 (444)585 (295)6395 (318)1218 (298) 20051329 (333)2148 (303)1756 (317)783 (445)640 (317)6656 (326)1243 (301) 20061376 (336)2232 (312)1870 (333)825 (464)684 (332)6987 (338)1256 (300) 20071425 (341)2286 (316)1961 (344)870 (484)709 (335)7251 (345)1300 (307) 20081505 (352)2394 (327)2095 (362)912 (502)748 (343)7654 (358)1350 (316) 20091576 (361)2497 (336)2252 (382)935 (508)787 (350)8047 (370)1404 (325) 20101649 (373)2648 (353)2416 (404)975 (524)818 (356)8506 (386)1440 (330) 20111717 (384)2740 (362)2573 (426)988 (528)860 (366)8878 (398)1483 (337) 20121810 (400)2866 (374)2718 (444)1029 (547)897 (372)9320 (413)1524 (344) * For calculation of population related totals, the population of these States were combined Patients lost to follow up are not included

24. ANZDATA Registry Annual Report 2013 Figure 8.21

25. ANZDATA Registry Annual Report 2013 Figure 8.22

26. ANZDATA Registry Annual Report 2013 Figure 8.23

27. ANZDATA Registry Annual Report 2013 Figure 8.24

28. ANZDATA Registry Annual Report 2013 Figure 8.25 Age of All Functioning Transplant Patients Resident Country at Transplant 31-Dec-2012 Donor Source Graft No. Age Groups Total 00-0405-1415-2425-3435-4445-5455-6465-7475-8485-94 Australia 12136292708155922582508152731469320 Deceased Donor 1 6408924971512401538102222855132 2 -484010319816382161615 3 --2825411811--105 4 ----563---14 5 -----11---2 Total 6449929784814861723111524465868 Living Donor 1 68918037662768772038665-3136 2 -31232716456215-264 3 --11111984--44 4 ---22211--8 Total 69219341171177278541270-3452 New Zealand 426591202213864232364631524 Deceased Donor 1 25125182178224151412748 2 --121432227--78 3 ----6552--18 Total 251353102215251160412844 Living Donor 1 22144621041511627651628 2 --25141710---48 3 ----13----4 Total 22146671191711727651680

29. ANZDATA Registry Annual Report 2013 Figure 8.26a

30. ANZDATA Registry Annual Report 2013 Figure 8.16b

31. ANZDATA Registry Annual Report 2013 Figure 8.27a

32. ANZDATA Registry Annual Report 2013 Figure 8.27b

33. ANZDATA Registry Annual Report 2013 Figure 8.28 Functioning Transplant Patients - Resident Country at Transplant Related to Ethnicity and Age Group 31-Dec-2012 GenderRacial Origin Prevalent Age Groups Total 00-0405-1415-2425-3435-4445-5455-6465-7475-8485-94 Australia 12136292708155922582508152731469320 Female Caucasian 23410023549269077852413222989 Aboriginal/TSI -2272125215--83 Asian 1483078101133477-409 Other 1882326292592-131 Total 44811829561784595758514123612 Male Caucasian 6681473558081219133585215844952 Aboriginal/TSI -357212934101-110 Asian -71332831261396311-474 Other 210919303943173-172 Total 8881744139421413155194217345708 New Zealand 426591202213864232364631524 Female Caucasian-825287511512976201477 Asian-1463171461-52 Maori-4461412963-58 Pacific-1-7614631-38 Other----------- Total-14334798158 91251625 Male Caucasian4102245102177193102162673 Asian---1181227133-74 Maori-141162622192-91 Pacific-1-5611199--51 Other---11242--10 Total4122673123228265145212899

34. ANZDATA Registry Annual Report 2013 Figure 8.29

35. ANZDATA Registry Annual Report 2013 Figure 8.30

36. ANZDATA Registry Annual Report 2013 Figure 8.31 Graft Loss Rate 2003 - 2012 2003200420052006200720082009201020112012 Australia 6401673970187297760280648427889393319723 Death with Function 2.2%2.1%2.3%2.0%2.1% 1.7%2.0%2.3%1.6% Loss of Graft Function 2.6%3.1%2.7%2.4%2.5%2.9%2.7%2.3% 2.4% All Losses 4.9%5.2%5.0%4.4%4.6%5.0%4.4%4.3%4.7%4.1% New Zealand 1224126913111333137914221471151415581591 Death with Function 2.2% 2.3%2.6%3.2%1.8%2.3%2.2%2.7%1.7% Loss of Graft Function 2.5%1.8%3.4%3.5%2.9%2.0%2.4%2.1%2.0%2.4% All Losses 4.7%4.0%5.6%6.0%6.1%3.9%4.7%4.4%4.7%4.1%

37. ANZDATA Registry Annual Report 2013 Figure 8.32 Year of Graft Loss Due to Death or Failure 2003 - 2012 LossCause of Failure20032004 200 5 200 6 200 7 200 8 200 9 201 0 201 1 2012Total Australia Failed Death with Function 146 1651461651751481772211641653 Rejection - Acute 3537111017810 84 Chronic Allograft (CAN) 1121451361081331741531491511781439 Rejection - Hyperacute ---1-2---14 Vascular 151813148 1711610126 Technical Problems 324524335233 Glomerulonephritis 12131623151015 16150 Non Compliance 10963861266975 Other 13201519171615182625184 Total 314358 3263594113803874404153748 New Zealand Failed Death with Function 27 3134442634334127324 Rejection - Acute 1-22111-3112 Chronic Allograft (CAN) 1814233120 28171526212 Rejection - Hyperacute -1--------1 Vascular 1-4-31232117 Technical Problems 2-231-----8 Glomerulonephritis 423655-44538 Non Compliance 3-1161153-21 Other 448451224539 Total 60487481855568647265672

38. ANZDATA Registry Annual Report 2013 Figure 8.33 Graft Losses 2008 - 2012 Cause of Loss AustraliaNew Zealand Graft Function <1 year>= 1 yearAny Time<1 year>= 1 yearAny Time Death with functioning Graft Cardiac 19 (27%)178 (22%)197 (22%)5 (50%)44 (29%)49 (30%) Vascular 7 (10%)69 (8%)76 (9%)1 (10%)8 (5%)9 (6%) Infection 29 (41%)133 (16%)162 (18%)-23 (15%)23 (14%) Social 2 (3%)66 (8%)68 (8%)1 (10%)8 (5%)9 (6%) Malignancy 5 (7%)276 (34%)281 (32%)2 (20%)53 (35%)55 (34%) Miscellaneous 8 (11%)93 (11%)101 (11%)1 (10%)15 (10%)16 (10%) Total 70 (100%)815 (100%)885 (100%)10 (100%)151 (100%)161 (100%) Graft Failure Rejection - Acute 30 (21%)25 (2%)55 (5%)-6 (4%) Rejection - Chronic Allograft (CAN) 10 (7%)795 (79%)805 (70%)1 (7%)105 (71%)106 (65%) Rejection - Hyperacute 3 (2%)-3 (<1%)--- Vascular 44 (31%)14 (1%)58 (5%)5 (33%)4 (3%)9 (6%) Technical Problems 12 (9%)5 (<1%)17 (1%)--- Glomerulonephritis 8 (6%)63 (6%)71 (6%)--- Non Compliance 1 (1%)38 (4%)39 (3%)1 (7%)9 (6%)10 (6%) Other 33 (23%)67 (7%)100 (9%)5 (33%)9 (6%)14 (9%) Total 141 (100%)1007 (100%)1148 (100%)15 (100%)148 (100%)163 (100%)

39. ANZDATA Registry Annual Report 2013 Figure 8.34 Australia Immunosuppressive Therapy - Primary Deceased Donor Graft 2005 - 2012 YearAzaCyATacrolMMFMPASirol Everolimu s Pred Number of Deceased Donor Grafts Initial treatment 20059 (3%)131 (41%)172 (54%)299 (94%)4 (1%)17 (5%)-308 (97%)319 2006-155 (51%)139 (45%)260 (85%)24 (8%)3 (1%)19 (6%)296 (97%)306 20072 (1%)138 (48%)140 (49%)244 (85%)36 (13%)-5 (2%)285 (99%)287 20082 (1%)137 (35%)240 (61%)364 (93%)22 (6%)--389 (99%)391 20094 (1%)62 (16%)310 (82%)356 (95%)13 (3%)-3 (1%)375 (100%)376 2010-66 (14%)409 (86%)426 (89%)37 (8%)1 (<1%)3 (1%)477 (100%)478 20111 (<1%)54 (11%)446 (87%)300 (59%) 204 (40%) --505 (99%)511 20121 (<1%)22 (4%)409 (77%)343 (64%)93 (17%)6 (1%)-440 (83%)533 Treatment at 12 months 200523 (8%)83 (29%)172 (59%)229 (79%)21 (7%)29 (10%)3 (1%)262 (90%)291 200612 (4%)94 (34%)145 (52%)216 (78%)27 (10%)21 (8%)20 (7%)259 (93%)278 200713 (5%)86 (32%)149 (56%)189 (71%)51 (19%)12 (5%)14 (5%)252 (95%)265 200817 (5%)84 (23%)251 (70%)288 (80%)37 (10%)12 (3%)9 (2%)345 (96%)361 200918 (5%)40 (11%)283 (80%)282 (80%)39 (11%)18 (5%)9 (3%)341 (96%)354 201024 (5%)52 (11%)370 (81%)323 (71%)82 (18%)16 (4%)11 (2%)440 (97%)454 201124 (5%)26 (5%)391 (81%)223 (46%) 179 (37%) 8 (2%)13 (3%)432 (89%)485 Treatment at 24 months 200523 (8%)76 (27%)156 (55%)220 (78%)23 (8%)45 (16%)5 (2%)238 (84%)282 200615 (6%)81 (30%)144 (53%)207 (76%)31 (11%)23 (8%)25 (9%)248 (92%)271 200712 (5%)79 (31%)152 (59%)181 (70%)54 (21%)14 (5%)13 (5%)243 (94%)259 200820 (6%)80 (23%)238 (68%)275 (79%)39 (11%)12 (3%)9 (3%)324 (93%)350 200923 (7%)39 (11%)273 (79%)254 (74%)53 (15%)20 (6%)11 (3%)328 (95%)344 201024 (6%)45 (10%)328 (76%)293 (68%)71 (16%)20 (5%)14 (3%)391 (91%)432 Aza = Azathioprine CyA = Cyclosporine Tacrol = Tacrolimus MMF = Mycophenolate Mofetil MPA = Mycophenolic Acid (Enteric Coated) Sirol = Sirolimus Pred = Prednisolone

40. ANZDATA Registry Annual Report 2013 Aza = Azathioprine CyA = Cyclosporine Tacrol = Tacrolimus MMF = Mycophenolate Mofetil MPA = Mycophenolic Acid (Enteric Coated) Sirol = Sirolimus Pred = Prednisolone Figure 8.35 New Zealand Immunosuppressive Therapy - Primary Deceased Donor Graft 2005 - 2012 YearAzaCyATacrolMMFMPASirol Everolimu s Pred Number of Deceased Donor Grafts Initial treatment 2005-32 (76%)8 (19%)41 (98%)--- 42 2006-26 (68%)11 (30%)34 (92%)--3 (8%)37 (100%)37 2007-43 (74%)15 (26%)57 (98%)--1 (2%)58 (100%)58 2008-30 (67%)15 (33%)42 (93%)3 (7%)--45 (100%)45 2009-39 (78%)10 (20%)49 (98%)--- 50 2010-32 (71%)13 (29%)45 (100%)--- 45 2011-41 (71%)17 (29%)58 (100%)--- 58 2012-33 (66%)13 (26%)46 (92%)--- 50 Treatment at 12 months 20052 (5%)21 (55%)16 (42%)33 (87%)1 (3%)2 (5%)1 (3%)35 (92%)38 2006-18 (53%)15 (45%)29 (88%)--3 (9%)32 (97%)33 20073 (6%)31 (60%)20 (38%)43 (83%)-2 (4%)1 (2%)48 (92%)52 20082 (5%)21 (48%)23 (52%)39 (89%)1 (2%)--41 (93%)44 2009-24 (50%)23 (48%)48 (100%)-1 (2%)-45 (94%)48 20102 (5%)16 (37%)27 (63%)41 (95%)---42 (98%)43 20112 (4%)22 (41%)27 (50%)45 (83%)---47 (87%)54 Treatment at 24 months 20052 (6%)18 (50%)17 (47%)30 (83%)1 (3%)2 (6%)1 (3%)29 (81%)36 2006-16 (50%) 28 (88%)--2 (6%)30 (94%)32 20073 (6%)29 (58%)20 (40%)41 (82%)-2 (4%)1 (2%)45 (90%)50 20082 (5%)20 (48%)22 (52%)37 (88%)-1 (2%)-40 (95%)42 2009-21 (46%)24 (52%)45 (98%)-1 (2%)-42 (91%)46 20102 (5%)15 (36%)25 (60%)37 (88%)--- 42

41. ANZDATA Registry Annual Report 2013 Figure 8.36 Antibody Use for Induction Immunosuppression Australia and New Zealand 2008 - 2012 Number of Kidney Transplant Recipients Receiving Each Agent by Year (% Total New Transplants) 20082009201020112012 Australia Muromonab-CD3-1 (0.1%)--13 (1.5%) Intravenous immunoglobulin25 (3.1%)28 (3.6%)39 (4.6%)42 (5.1%)26 (3.1%) Anti-CD25740 (91.0%)715 (92.5%)800 (94.6%)765 (92.7%)569 (67.3%) Rituximab21 (2.6%)17 (2.2%)9 (1.1%)10 (1.2%)7 (0.8%) T cell depleting polyclonal Ab22 (2.7%)40 (5.2%)52 (6.1%)33 (4.0%)20 (2.4%) Total new transplants813773846825845 ----5 (0.6%) New Zealand Intravenous immunoglobulin----1 (0.9%) Anti-CD2574 (60.7%)63 (52.1%)65 (59.1%)114 (96.6%)99 (91.7%) Rituximab1 (0.8%)2 (1.7%)1 (0.9%)3 (2.5%)4 (3.7%) T cell depleting polyclonal Ab--1 (0.9%)1 (0.8%)- Total new transplants122121110118108

42. ANZDATA Registry Annual Report 2013 Figure 8.37 Antibody Use as Treatment for Acute Rejection Australia and New Zealand 2008 - 2012 Number of Kidney Transplant Recipients Receiving Each Agent by Year (% Total New Transplants) 20082009201020112012 Australia Muromonab-CD310 (1.2%)12 (1.6%)2 (0.2%)-- Intravenous immunoglobulin89 (10.9%)105 (13.6%)92 (10.9%)105 (12.7%)41 (4.9%) Anti-CD251 (0.1%) --- Rituximab24 (3.0%)26 (3.4%)15 (1.8%)11 (1.3%)6 (0.7%) T cell depleting polyclonal Ab19 (2.3%)27 (3.5%)41 (4.8%)42 (5.1%)20 (2.4%) Total new transplants813773846825845 Total transplants at risk80648427889393319723 New Zealand Muromonab-CD310 (8.2%)8 (6.6%)4 (3.6%)-- Intravenous immunoglobulin2 (1.6%)7 (5.8%)4 (3.6%)3 (2.5%)3 (2.8%) Anti-CD251 (0.8%)-- - Rituximab-3 (2.5%)--1 (0.9%) T cell depleting polyclonal Ab3 (2.5%)2 (1.7%)12 (10.9%)11 (9.3%)4 (3.7%) Total new transplants122121110118108 Total transplants at risk14221471151415581591

43. ANZDATA Registry Annual Report 2013 Figure 8.38 Australia and New Zealand Rejection Rates at Six Months Post Transplant Donor Source2003200420052006200720082009201020112012 Living Donor First graft 27.7%21.6%19.6% 21.1%17.0%16.8%17.8%17.5%11.0% Second and subsequent grafts 33.3%34.8%18.5%33.3%34.3%30.0%24.3%12.9%18.5%10.3% Deceased Donor First graft 26.8%22.8%18.6%16.3%17.7%22.0%21.1%18.7%20.0%13.7% Second and subsequent grafts 25.0%27.5%31.7%36.4%32.8%32.9%36.5%27.3%17.7%19.2%

44. ANZDATA Registry Annual Report 2013 Figure 8.39 Primary Deceased Donor - Australia Recipient and Graft Survival 1993 - 2012 % [95% Confidence Interval] Year of Transplant Survival 1 month6 months1 year5 years Recipient Survival 1993-1994 (n=609)99 (97, 99)96 (94, 97)95 (93, 97)85 (82, 88) 1995-1996 (n=601)99 (98, 100)96 (94, 97)95 (93, 97)88 (85, 90) 1997-1998 (n=606)99 (97, 99)97 (95, 98)96 (94, 97)87 (84, 89) 1999-2000 (n=559)99 (98, 100)97 (96, 98)96 (94, 97)87 (84, 90) 2001-2002 (n=615)99 (98, 100)97 (96, 98)96 (94, 97)90 (88, 92) 2003-2004 (n=636)99 (98, 100)97 (95, 98)96 (94, 97)88 (85, 90) 2005-2006 (n=625)99 (98, 100)97 (96, 98)96 (94, 97)89 (86, 91) 2007-2008 (n=678)99 (98, 100)98 (97, 99)97 (96, 98)91 (89, 93) 2009-2010 (n=854)99 (98, 100)98 (97, 99)98 (96, 98)- 2011-2012 (n=1044)100 (99, 100)98 (97, 99)97 (96, 98)- Graft Survival 1993-1994 (n=609)93 (91, 95)89 (86, 91)88 (85, 90)73 (69, 76) 1995-1996 (n=601)95 (92, 96)90 (88, 92)89 (86, 91)78 (74, 81) 1997-1998 (n=606)95 (93, 97)92 (90, 94)90 (88, 92)77 (74, 80) 1999-2000 (n=559)96 (95, 98)93 (91, 95)92 (89, 94)80 (76, 83) 2001-2002 (n=615)96 (94, 97)94 (92, 96)92 (90, 94)82 (79, 85) 2003-2004 (n=636)94 (92, 96)92 (90, 94)91 (88, 93)80 (76, 83) 2005-2006 (n=625)95 (93, 97)93 (91, 95)91 (89, 93)79 (76, 82) 2007-2008 (n=678)96 (94, 97)94 (92, 95)92 (90, 94)81 (78, 84) 2009-2010 (n=854)98 (97, 99)96 (95, 97)95 (93, 96)- 2011-2012 (n=1044)98 (97, 99)96 (94, 97)95 (93, 96)-

45. ANZDATA Registry Annual Report 2013 Figure 8.40a

46. ANZDATA Registry Annual Report 2013 Figure 8.40b

47. ANZDATA Registry Annual Report 2013 Figure 8.43 Recipient and Graft Survival of Primary Grafts Deceased Donors - Australia and New Zealand Recipient Survival Graft Survival Time Period1 year5 yrs10 yrs15 yrs20 yrs 1 year5 yrs10 yrs15 yrs20 yrs 1970-1974 (n=1149)77.0%57.4%44.4%34.2%25.1% 58.2%41.9%30.3%22.8%14.6% 1975-1979 (n=1463)81.0%63.6%49.4%35.5%26.2% 51.7%36.0%25.6%17.7%12.6% 1980-1984 (n=1595)91.4%75.1%59.4%45.9%34.7% 63.3%45.4%32.1%23.0%16.2% 1985-1989 (n=1916)92.1%80.3%64.5%51.2%39.6% 80.8%65.8%47.2%32.9%21.4% 1990-1994 (n=1906)93.4%83.9%67.7%53.2%40.9% 85.0%70.9%50.7%34.7%23.7% 1995-1999 (n=1779)94.7%86.1%72.4%57.1%- 88.6%76.2%58.6%41.7%- 2000-2004 (n=1850)96.0%89.1%77.0%-- 91.6%80.8%64.0%-- 2005-2009 (n=1911)96.7%89.5%--- 92.3%80.5%--- 2010-2014 (n=1675)97.5%---- 94.9%----

48. ANZDATA Registry Annual Report 2013 Figure 8.44

49. ANZDATA Registry Annual Report 2013 Figure 8.45 Second and Subsequent Deceased Donor - Australia Recipient and Graft Survival 1993 - 2012 % [95% Confidence Interval] Year of Transplant Survival 1 month6 months1 year5 years Recipient Survival 1993-1994 (n=121)98 (94, 100)98 (93, 99)94 (88, 97)86 (78, 91) 1995-1996 (n=107)99 (94, 100)97 (92, 99) 86 (78, 91) 1997-1998 (n=109)10097 (92, 99)95 (89, 98)86 (78, 91) 1999-2000 (n=77)99 (91, 100)96 (88, 99)95 (87, 98)86 (76, 92) 2001-2002 (n=87)99 (92, 100)94 (87, 98)92 (84, 96)87 (78, 93) 2003-2004 (n=95)99 (93, 100)98 (92, 99)95 (88, 98)85 (76, 91) 2005-2006 (n=120)10099 (94, 100)97 (91, 99)88 (81, 93) 2007-2008 (n=125)99 (94, 100)98 (93, 99)96 (91, 98)85 (76, 90) 2009-2010 (n=142)99 (95, 100)97 (93, 99)95 (90, 98)- 2011-2012 (n=133)10099 (94, 100) - Graft Survival 1993-1994 (n=121)87 (79, 92)85 (77, 90)83 (76, 89)70 (61, 78) 1995-1996 (n=107)83 (75, 89)78 (68, 84)77 (67, 84)61 (51, 69) 1997-1998 (n=109)93 (86, 96)89 (81, 94)84 (76, 90)73 (64, 81) 1999-2000 (n=77)92 (83, 96)88 (79, 94)87 (77, 93)68 (56, 77) 2001-2002 (n=87)92 (84, 96)85 (76, 91)82 (72, 88)67 (56, 75) 2003-2004 (n=95)94 (86, 97) 89 (81, 94)72 (61, 80) 2005-2006 (n=120)97 (91, 99)93 (87, 97)89 (82, 94)71 (62, 78) 2007-2008 (n=125)96 (91, 98)93 (87, 96)90 (84, 94)70 (61, 78) 2009-2010 (n=142)94 (89, 97)93 (87, 96)91 (85, 95)- 2011-2012 (n=133)98 (94, 100)98 (93, 99)95 (89, 98)-

50. ANZDATA Registry Annual Report 2013 Figure 8.46a

51. ANZDATA Registry Annual Report 2013 Figure 8.46b

52. ANZDATA Registry Annual Report 2013 Figure 8.47 Recipient and Graft Survival of Second and Subsequent Grafts Deceased Donors Australia and New Zealand Recipient Survival Graft Survival Time Period1 year5 yrs10 yrs15 yrs20 yrs 1 year5 yrs10 yrs15 yrs20 yrs 1970-1974 (n=158)79.1%55.7%42.4%33.5%26.6% 58.9%37.3%27.2%21.5%14.6% 1975-1979 (n=284)78.2%57.4%44.7%31.3%20.0% 44.0%28.2%20.4%15.0%8.1% 1980-1984 (n=417)90.6%74.8%59.0%46.8%37.1% 48.9%36.0%25.6%20.3%14.2% 1985-1989 (n=458)93.7%79.2%62.8%47.3%35.1% 70.1%51.7%34.4%23.2%13.9% 1990-1994 (n=374)93.0%82.6%67.9%54.0%40.8% 78.3%64.2%44.1%31.2%21.0% 1995-1999 (n=296)95.9%86.1%73.3%60.0%- 81.8%66.6%44.3%31.1%- 2000-2004 (n=268)93.7%86.2%74.8%-- 86.6%70.1%51.5%-- 2005-2009 (n=343)96.2%87.9%--- 89.5%73.1%--- 2010-2014 (n=217)96.3%---- 93.4%----

53. ANZDATA Registry Annual Report 2013 Figure 8.48

54. ANZDATA Registry Annual Report 2013 Figure 8.49 Australia Year of Transplant Primary Living Donor Grafts 1993 - 2012 Recipient and Graft Survival % [95% Confidence Interval] 1 month6 months1 year5 years Recipient Survival 1993-1994 (n=160)10099 (95, 100)98 (94, 99)94 (89, 97) 1995-1996 (n=186)10098 (95, 99)97 (94, 99)95 (90, 97) 1997-1998 (n=284)10099 (96, 99)98 (96, 99)96 (93, 98) 1999-2000 (n=320)99 (98, 100)98 (96, 99) 94 (91, 96) 2001-2002 (n=410)100 (98, 100)99 (97, 100)99 (97, 99)95 (92, 97) 2003-2004 (n=419)100 (98, 100)99 (97, 100) 94 (92, 96) 2005-2006 (n=463)100 (98, 100) 99 (98, 100)97 (95, 98) 2007-2008 (n=557)100 (99, 100)99 (97, 99) 94 (92, 96) 2009-2010 (n=564)100 (99, 100)99 (98, 100)98 (97, 99)- 2011-2012 (n=447)100100 (98, 100) - Graft Survival 1993-1994 (n=160)97 (93, 99)96 (91, 98)95 (90, 97)85 (78, 90) 1995-1996 (n=186)93 (88, 96)91 (86, 94)90 (84, 93)84 (78, 89) 1997-1998 (n=284)98 (96, 99)97 (94, 98)96 (94, 98)87 (82, 90) 1999-2000 (n=320)97 (94, 98)95 (92, 97)94 (91, 96)86 (82, 90) 2001-2002 (n=410)98 (96, 99)96 (94, 98)96 (93, 97)88 (85, 91) 2003-2004 (n=419)99 (97, 100)98 (96, 99)97 (95, 98)88 (84, 91) 2005-2006 (n=463)98 (97, 99)98 (96, 99)97 (95, 98)90 (87, 93) 2007-2008 (n=557)98 (96, 99)97 (95, 98) 88 (85, 91) 2009-2010 (n=564)99 (98, 100)98 (97, 99)97 (95, 98)- 2011-2012 (n=447)99 (97, 99)98 (96, 99) -

55. ANZDATA Registry Annual Report 2013 Figure 8.50 New Zealand Year of Transplant Primary Living Donor Grafts 1993 - 2012 Recipient and Graft Survival % [95% Confidence Interval] 1 month6 months1 year5 years Recipient Survival 1993-1994 (n=160)10099 (95, 100)98 (94, 99)94 (89, 97) 1995-1996 (n=186)10098 (95, 99)97 (94, 99)95 (90, 97) 1997-1998 (n=284)10099 (96, 99)98 (96, 99)96 (93, 98) 1999-2000 (n=320)99 (98, 100)98 (96, 99) 94 (91, 96) 2001-2002 (n=410)100 (98, 100)99 (97, 100)99 (97, 99)95 (92, 97) 2003-2004 (n=419)100 (98, 100)99 (97, 100) 94 (92, 96) 2005-2006 (n=463)100 (98, 100) 99 (98, 100)97 (95, 98) 2007-2008 (n=557)100 (99, 100)99 (97, 99) 94 (92, 96) 2009-2010 (n=564)100 (99, 100)99 (98, 100)98 (97, 99)- 2011-2012 (n=447)100100 (98, 100) - Graft Survival 1993-1994 (n=35)91 (76, 97)89 (72, 96) 74 (56, 86) 1995-1996 (n=46)98 (86, 100) 76 (61, 86) 1997-1998 (n=57)96 (87, 99) 95 (85, 98)72 (58, 82) 1999-2000 (n=66)95 (87, 99)94 (85, 98) 82 (70, 89) 2001-2002 (n=83)10099 (92, 100) 88 (79, 93) 2003-2004 (n=88)97 (90, 99)95 (88, 98) 86 (77, 92) 2005-2006 (n=88)99 (92, 100)97 (90, 99)95 (88, 98)91 (83, 95) 2007-2008 (n=120)98 (94, 100)98 (92, 99)97 (91, 99)84 (76, 90) 2009-2010 (n=118)99 (94, 100)97 (92, 99)97 (91, 99)- 2011-2012 (n=101)97 (91, 99) 95 (87, 98)-

56. ANZDATA Registry Annual Report 2013 Figure 8.51

57. ANZDATA Registry Annual Report 2013 Figure 8.52

58. ANZDATA Registry Annual Report 2013 Figure 8.53

59. ANZDATA Registry Annual Report 2013 Figure 8.54

60. ANZDATA Registry Annual Report 2013 Figure 8.55 Recipient and Graft Survival of Primary Grafts Living Donors - Australia and New Zealand Recipient Survival Graft Survival Time Period1 year5 yrs10 yrs15 yrs20 yrs 1 year5 yrs10 yrs15 yrs20 yrs 1970-1974 (n=21)90.5%81.0%61.9%52.4%42.9% 85.7%76.2%61.5%46.2%20.5% 1975-1979 (n=107)90.7%78.5%71.0%61.7%52.2% 81.2%63.3%49.9%41.2%31.1% 1980-1984 (n=241)96.3%85.4%74.9%64.8%55.4% 82.8%71.2%59.3%46.5%35.9% 1985-1989 (n=230)95.2%87.8%79.9%71.1%62.9% 90.8%74.8%60.5%45.1%35.0% 1990-1994 (n=431)97.2%89.2%84.0%74.5%68.5% 91.8%79.6%65.3%48.8%32.0% 1995-1999 (n=766)98.6%94.7%86.6%76.8%- 94.5%84.0%68.8%52.1%- 2000-2004 (n=1193)98.5%94.3%86.6%-- 95.9%87.7%72.4%-- 2005-2009 (n=1585)98.5%95.2%--- 96.7%89.1%--- 2010-2014 (n=873)99.0%---- 97.2%----

61. ANZDATA Registry Annual Report 2013 Figure 8.56

62. ANZDATA Registry Annual Report 2013 Figure 8.57 Recipient and Graft Survival of Second and Subsequent Grafts Living Donors - Australia and New Zealand Recipient Survival GraftSurvival Time Period1 year5 yrs10 yrs15 yrs20 yrs 1 year5 yrs10 yrs15 yrs20 yrs 1970-1974 (n=1)100.0% --- --- 1975-1979 (n=11)100.0% 81.8%72.7%63.6% 72.7%45.5%36.4% 27.3% 1980-1984 (n=42)97.6%81.0%78.6%71.4%51.9% 78.6%64.3%59.5%50.0%40.5% 1985-1989 (n=31)96.8%83.9%71.0%64.5%47.5% 87.1%74.2%58.1%45.2%29.0% 1990-1994 (n=38)100.0%94.7%73.3%67.9%51.3% 100.0%86.8%41.2%35.7%24.7% 1995-1999 (n=74)98.6% 89.2%81.1%- 93.2%82.4%68.9%57.9%- 2000-2004 (n=107)98.1%95.3%85.7%-- 93.5%85.0%67.2%-- 2005-2009 (n=175)98.3%93.2%--- 95.4%82.1%--- 2010-2014 (n=87)98.7%---- 95.2%----

63. ANZDATA Registry Annual Report 2013 Figure 8.58