2. NIHR Grant Programme RP-PG-0707-10012 Executive Team Meeting 28 September 2010 Glanville Centre, Salisbury District Hospital

3. Agenda 9.00 – 9.10 Coffee 9.10 – 9.30 Intro and 18/12 report Ian Swain 9.30 – 10.15 WP1 progress to date Damian Jenkinson/Gabrielle Mc Hugh 10.15 – 11.00 WP2 progress to date Anand Pandyan/Sybil Farmer 11.00 – 11.30 Coffee 11.30 – 12.30 WP3 progress to date Jane Burridge, Ann-Marie Hughes, Sara Demain 12.30 – 13.30 Lunch 13.30 – 15.00 Preparation for CT application -Due on 1/3/11 -Dates for WP information All 15.00 – 15.30 Tea 15.30 – 17.00 CT application continued All 17.00DONM

4. NIHR PROGRAMME GRANT v3 09 10 11 Version 2 if trial not funded Start date 1/1/09 (Q1) Q1Q2Q3Q4Q1Q2Q3Q4Q1Q2Q3Q4 Task WP1 - Review of existing services Identification of centres Qualitative design phase workshop Drafting of questionnaire Piloting of questionnaire Analysis of pilot results Modification of questionnaire Main questionnaire and follow up Analysis of results Producing review for publication Updating existing services review Reports 20/11/ 09 20/11/ 10 01/03/ 11 20/11/ 10

5. WP2 - Literature review 09 Q1Q2Q3Q4 10 Q1Q2Q3Q4 11 Q1Q2Q3Q4 Planning the review Conducting the searches Selection of articles Review process Peer review by management team Audit of article selection Audit of reviewed articles Updating of reviews Publication of systematic reviews Reports 20/11/ 2009 20/11/ 2010 01/03/ 2011 20/11/ 2010

6. WP3 - Acceptability of ATs 09 Q1Q2Q3Q4 10 Q1Q2Q3Q4 11 Q1Q2Q3Q4 Ethical application and approval Design, running and evaluating the interactive exhibition Focus groups Focus group analysis Questionnaire design Questionnaire validation Questionnaire data collection Questionnaire analysis Field trials design Dissemination Reports 20/11/ 2009 20/11/ 2010 01/03/ 2011 20/11/ 2010

7. WP4 - Clinical Trials 09 Q1Q2Q3Q4 10 Q1Q2Q3Q4 11 Q1Q2Q3 Q4/Q1 2012 WP4 Phase 1 AT selection procedure and consultation Decision on what ATs to include in Phase 2 Trial design WP4 Phase 2 JDs and advert for therapists WP6 - Dissemination Annual/Financial Report 01/03/ 2010 01/09 /2010 01/03/ 2011 01/03/ 2012 Trial design report (major report) 15/03/2 011 Presenting at key meetings Writing final report Publishing book/special edition International conference

8. AHP process Seminars and workshops given by Maarten IjzermanSeminars and workshops given by Maarten Ijzerman Its been used in Healthcare for the last 10 yearsIts been used in Healthcare for the last 10 years Combines clinical experience with systematic reviews.Combines clinical experience with systematic reviews. Define attributes, both primary and secondary and assign attribute weights to themDefine attributes, both primary and secondary and assign attribute weights to them Identify alternative treatmentsIdentify alternative treatments Undertake comparisons in order to get performance weights.Undertake comparisons in order to get performance weights. Done using Expert choice softwareDone using Expert choice software

9. Attributes Determined by Exec team in March and confirmed with Steering Committee FunctionFunction ComfortComfort RisksRisks –Short term –Long term Daily effort (patient)Daily effort (patient) –Time –Complexity Impact on Health ServiceImpact on Health Service –Time –Complexity

10. Alternative Treatments Peripheral FESPeripheral FES Central/cortical stimulationCentral/cortical stimulation CIMTCIMT RoboticsRobotics Active orthoticsActive orthotics BiofeedbackBiofeedback VR including WiiVR including Wii

11. Pair wise comparisons Undertaken by Steering Committee as expert group In order to get performance weightsIn order to get performance weights E.g. how would you rate FES and CIMT in terms of comfort.E.g. how would you rate FES and CIMT in terms of comfort. Replace performance weights with objective data from WP2Replace performance weights with objective data from WP2 In absence of objective data use expert opinion from Steering CommitteeIn absence of objective data use expert opinion from Steering Committee Use subjects from WP3 to give patient perspective to attribute weightsUse subjects from WP3 to give patient perspective to attribute weights

12. Combining data Use results of AHP process, professionals and patientsUse results of AHP process, professionals and patients Use HE informationUse HE information Use WP1 to look at prevalence of impairmentsUse WP1 to look at prevalence of impairments Come to final conclusion - re two selected interventions and use WP1 to determine control group.Come to final conclusion - re two selected interventions and use WP1 to determine control group.

13. www.atrasproject.org