1. To know more visit HeartFailure.com © 2015 Novartis Pharma AG, May 2015, GLCM/HTF/0028 HEART FAILURE MORTALITY STATISTICS

2. Heart failure mortality statistics Mortality rates in heart failure are high even for patients compliant with the best available treatments 1 ~50 % DIE WITHIN 5 YEARS OF DIAGNOSIS 2 When heart failure symptoms are stabilised by current treatments, it may seem that patients are doing well, but the neurohormonal imbalance underlying heart failure is still silently occurring, resulting in disease progression. 1 The impact of heart failure on individuals is significant, and the worldwide prevalence is high 1. Fauci AS, Braunwald E, Kasper DL, et al, eds. Harrison's Principles of Internal Medicine. 17th ed. New York: McGraw-Hill; 2008. 2. Roger VL, Weston SA, Redfield MM, et al. Trends in heart failure incidence and survival in a community-based population. JAMA. 2004;292(3):344-350.

3. All heart failure patients, even those who are considered asymptomatic (NYHA class I) or mildly symptomatic (NYHA class II), are at high risk of dying 1 34 % OF NYHA CLASS I AND II PATIENTS DIED The neurohormonal imbalance that causes the disease to progress is present in all heart failure patients, even in those who are considered asymptomatic (NYHA class I) or mildly symptomatic (NYHA class II). 1-3 42 % OF NYHA CLASS III AND IV PATIENTS DIED 1. Ahmed A. A propensity matched study of New York Heart Association class and natural history end points in heart failure. Am J Cardiol. 2007;99(4):549-553. 2. Fauci AS, Braunwald E, Kasper DL, et al, eds. Harrison's Principles of Internal Medicine. 17th ed. New York: McGraw-Hill; 2008. 3. Yancy CW, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2013;128(16):e240-e327. Heart failure mortality statistics IN A CLINICAL TRIAL WITH MEDIAN FOLLOW-UP OF ~3YEARS

4. Sudden death is the most frequent cause of cardiovascular (CV) mortality among systolic heart failure patients 1 * ~45 % OF CARDIOVASCULAR DEATHS ARE DUE TO SUDDEN DEATH* 1 Mildly symptomatic patients are at a higher risk of sudden death, but the overall risk of death increases with escalation of NYHA class. 1,2 *In NYHA classes II through IV; roughly 70% of patients studied were NYHA class II. 1. Desai A.S. et al, Effect of angiotensin-receptor-neprilysin inhibitor LCZ696 compared with Enalapril on mode of death in heart failure patients, European Heart Journal, 2015; 2. Mozaffarian D, Benjamin EJ, Go AS, et al; for American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics—2015 update: a report from the American Heart Association. Circulation. 2015;131(4):e29-e322. Heart failure mortality statistics

5. Despite improvements in care, 1-year mortality rates for heart failure patients remain high 1 IN OF HEART FAILURE PATIENTS DIE WITHIN 1 YEAR OF DIAGNOSIS 1 Heart failure is a complex chronic condition exacerbated by neurohormonal imbalance and punctuated by acute episodes, leading to a spiral of deteriorating organ function and poor outcomes for patients. 2,3 1. Levy D, Kenchaiah S, Larson MG, et al. Long-term trends in the incidence of and survival with heart failure. N Engl J Med. 2002;347(18):1397-1402. 2. Fauci AS, Braunwald E, Kasper DL, et al, eds. Harrison's Principles of Internal Medicine. 17th ed. New York: McGraw-Hill; 2008. 3. Mann DL, Zipes DP, Libby P, Bonow RO, eds. Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine. 10th ed. Philadelphia: Saunders; 2015. 4 Heart failure mortality statistics