We think you have liked this presentation. If you wish to download it, please recommend it to your friends in any social system. Share buttons are a little bit lower. Thank you!
Presentation is loading. Please wait.
Published byPatrick Russo
Modified over 2 years ago
Hereditary aspects of upper GI malignancy Eamonn Sheridan Consultant in Clinical Genetics
Familial tendancy to malignancy Tends to be dominant Early onset of disease Rare –FAP 1/8000 –HNPCC 1/2500 –Peutz Jeghers 1/50000 –Juvenile polyposis 1/100,000 –TOC two families Extra GIT features
Familial risks Expressed as odds ratios Oesophageal cancer 1.6 Gastric cancer Small bowel tumours No indication for screening at these levels of risk
Mendelian cancer predisposition syndromes FAP HNPCC Gastric cancer Peutz Jegher Juvenile polyposis
FAP Hundreds of colonic polyps in second and third decades Extracolonic manifestations Gastric polyps Duodenal polyps Clear excess of ampullary cancers
HNPCC No biological phenotype Amsterdam criteria RR stomach cancer 4.1 median age 54 RR small bowel 25 median age 53 RR Hepatobiliary system 4.9 age 66
Peutz Jegher syndrome Excess of small bowel tumours Difficult to identify Intusseception Obstruction Torsion
Dominant Gastric cancer extremely rare Few families only with multiple affecteds Mutations in -catenin gene Screening unproven
Oesophageal cancer Minimal familial tendancy Two large families with TOC Linked to chromosome 17 No gene as yet
Conclusions Low relative risk for most of these tumours May be significant risks if part of other syndrome Screening uncertain
Familial adenomatous polyposis Best Practice Guidelines.
Colorectal Carcinoma- An Overview Dr C. L Chaw ST4, Clinical Oncology Tayside.
Courtney Rice, MS Certified Genetic Counselor TriHealth March 24, 2012 OSGNA Educational Conference Hereditary GI Cancer Syndromes: Keys to identify high.
This short questionnaire will help to determine whether there may be a gene in your family connected to an increased risk of the development of bowel.
Colon Cancer The life time risk of developing Colon Cancer in the United States in one in sixteen. This means 144,000 new cases a year accounting for 9%
Pathophysiology Colon CA. Most colorectal cancers, regardless of etiology, arise from adenomatous polyps. Polyp - a grossly visible protrusion from the.
© 2009 NHS National Genetics Education and Development CentreGenetics and Genomics for Healthcare Inherited Pre-disposition.
Ruanto, M.T., Sabalvaro, D.K., Salac, C.N., Salazar, J. References: Harrison’s Principle of Internal Medicine 17 th edition
Supporting Genetics Education for Health Practical Genetics for Primary Care Kate May Genetic Counsellor Nottingham Clinical.
UPPER GI BLEEDING: COLON CANCER GROUP A BGD February 1, 2010.
Tumors of Intestines. Introduction Overall, colorectal cancer ranks second only to bronchogenic carcinoma among the cancer killers. Overall, colorectal.
Skin and SubQ Basic Science 4/6/10 Dr. Bennett Fontenot MD, PhD, JD, RN, RD, DMD, DDS, NP, BS, esq, PA.
Breast Cancer Risk Assessment and Genetic Testing Susan W. Caro, RNC, MSN, APNG Director, Family Cancer Risk Service Vanderbilt-Ingram Cancer Center.
Pictorial lesson in GI Cancers. Oesophageal Cancer.
GENOMIC MEDICINE AND PUBLIC HEALTH August 16, 2000 Alan E. Guttmacher, M.D. Senior Clinical Advisor to the Director National Human Genome Research Institute.
© 2009 NHS National Genetics Education and Development CentreGenetics and Genomics for Healthcare Classification of Genetic.
Part Two Welcome back. Familial Cancer Genetics Cancer Genetics 5-10% of all cancer clearly linked to an inherited gene alteration If cancer seen at.
Linkage and Genetic Mapping Lecture 1 Human Molecular Genetics (Strachan and Read) Chapters 4, 13, 14.
Medical Genetics 1 Prof Duncan Shaw
Chapter 19 Essential Concepts in Molecular Pathology Companion site for Molecular Pathology Author: William B. Coleman and Gregory J. Tsongalis.
TUMORS OF THE AMPULLA OF VATER Aswad H. Al.Obeidy FICMS, FICMS GE&Hep Kirkuk General Hospital.
GI Bleeding in Children Maria Christina H. Ventura, MD, DPPS July 8, 2010.
Universal Screening for Lynch Syndrome Cecelia Bellcross, PhD, MS, CGC Emory University School of Medicine Department of Human Genetics.
Medical Genetics Textbooks: Emerys Elements of Medical genetics Strachan & Read Human Molecular Genetics (for the genome project material)
International Society for Gastrointestinal Hereditary Tumours (InSiGHT): Edited highlights Düsseldorf, 2009.
The Economic Stakes Involved in Genetic Testing for Insurance Companies Angus Macdonald Heriot-Watt University, Edinburgh and the Maxwell Institute for.
$100 $200 $300 $400 $500 $100$100$100 $200 $300 $400 $500 Topic 1Topic 2Topic 3Topic 4 Topic 5 FINAL ROUND.
© 2009 NHS National Genetics Education and Development CentreSupporting Genetics Education for Health Multifactorial conditions.
CANCER SCREENING TESTS: EVALUATING THE EVIDENCE Leah Karliner, MD, MAS Department of Medicine UCSF.
Is there a link between inflammatory bowel disease and the metabolic syndrome? Hester Franks Academic F2 Supervisors Professors Hawkey and Macdonald.
© 2016 SlidePlayer.com Inc. All rights reserved.