We think you have liked this presentation. If you wish to download it, please recommend it to your friends in any social system. Share buttons are a little bit lower. Thank you!
Presentation is loading. Please wait.
Published byPatrick Russo
Modified over 4 years ago
Hereditary aspects of upper GI malignancy Eamonn Sheridan Consultant in Clinical Genetics
Familial tendancy to malignancy Tends to be dominant Early onset of disease Rare –FAP 1/8000 –HNPCC 1/2500 –Peutz Jeghers 1/50000 –Juvenile polyposis 1/100,000 –TOC two families Extra GIT features
Familial risks Expressed as odds ratios Oesophageal cancer 1.6 Gastric cancer 2.1- 3.1 Small bowel tumours 2.6-3.1 No indication for screening at these levels of risk
Mendelian cancer predisposition syndromes FAP HNPCC Gastric cancer Peutz Jegher Juvenile polyposis
FAP Hundreds of colonic polyps in second and third decades Extracolonic manifestations Gastric polyps Duodenal polyps Clear excess of ampullary cancers
HNPCC No biological phenotype Amsterdam criteria RR stomach cancer 4.1 median age 54 RR small bowel 25 median age 53 RR Hepatobiliary system 4.9 age 66
Peutz Jegher syndrome Excess of small bowel tumours Difficult to identify Intusseception Obstruction Torsion
Dominant Gastric cancer extremely rare Few families only with multiple affecteds Mutations in -catenin gene Screening unproven
Oesophageal cancer Minimal familial tendancy Two large families with TOC Linked to chromosome 17 No gene as yet
Conclusions Low relative risk for most of these tumours May be significant risks if part of other syndrome Screening uncertain
Colon Cancer The life time risk of developing Colon Cancer in the United States in one in sixteen. This means 144,000 new cases a year accounting for.
Colorectal Carcinoma- An Overview
© 2009 NHS National Genetics Education and Development CentreGenetics and Genomics for Healthcare Inherited Pre-disposition.
This short questionnaire will help to determine whether there may be a gene in your family connected to an increased risk of the development of bowel.
Familial adenomatous polyposis
Hereditary GI Cancer-a Primer for Medical Oncologists
The Human Genome 23 Pairs of Chromosomes About 30,000 Genes.
Cancer and Cell Biology. Cancer Facts Group of 100 diseases that develop across time Characterized by uncontrolled cell division Can develop in virtually.
Pathophysiology Colon CA. Most colorectal cancers, regardless of etiology, arise from adenomatous polyps. Polyp - a grossly visible protrusion from the.
Hereditary GI Cancer Syndromes: Keys to identify high risk patients
Genetics and Pathology What can they do for each other? Scottish Association of Histotechnology; Friday 27 th May 2011.
1 An Update on Evolving Colorectal Screening Issues May 19, 2011 This first part today will be presented by: Stanley H. Weiss, MD, FACP, FACE Professor,
Genetics of Gastrointestinal Neoplasia 张咸宁 Tel ： ; Office: A709, Research Building 2012/04.
Introduction to Cancer Genetics
Gene 210 Cancer Genomics April 29, Key events in investigating the cancer genome M R Stratton Science 2011;331:
Lynch Syndrome and Colorectal Cancer Steven G. Proshan, M.D. Annapolis Colon and Rectal Surgeons Anne Arundel Medical Center November 8,
Update on Screening of Gastrointestinal Diseases Niraj Jani, M.D. Greater Baltimore Medical Center 1/30/15.
Screening for Colorectal Cancer Cancer Symposium: Measuring the Benefits of Screening and Treatment October 2007.
A few thoughts on cancer and cancer family syndromes Pamela McGrann, MD. Department of Medical Genetics.
COLORECTAL BLEEDING: a multidisciplinary approach Torino, 31 marzo-1 aprile 2006 GENETIC EVALUATION Schena M, Angelini F, Bertetto O. Department of Medical.
© 2018 SlidePlayer.com Inc. All rights reserved.