Presentation on theme: "Nature, Nurture and Mood Disorders at the MRC SGDP Centre."— Presentation transcript:
Nature, Nurture and Mood Disorders at the MRC SGDP Centre
§Life events ( LE) are familial (McGuffin et al 1988) §For severe events this is because they are often shared ( Farmer et al 2000) §G self reported LE and G depression correlated ( Plomin, Eley) §G and LE interact ( Farmer, Caspi)
Same Genes Different Disorders? §The G of mania and depression correlated ( not just a continuum of severity) (McGuffin et al 2003) §The G of schizophrenia, schizo-affective and bipolar disorder correlated (Cardno et al 2002) §This confirmed by molecular genetics
Molecules and mood §5HTTLPR and LE interact ( Caspi et al 2003) §We can track genes in families ( if we have enough families) ( eg Breen et al 2011) §We can tag genes in unrelateds– GWAS (if we have huge samples) ( eg Lewis et al 2010) §Some completely unforeseen quirks of the genome have emerged such as CNVs (eg Rucker et al 2011) §Its complex!
Your consent to our cookies if you continue to use this website.