1. Contents What is Blood? Plasma and cells in suspension Plasma functions Red blood cells White blood cells Blood cells Summary quiz

2. 2 of 50 Plasma and cells in suspension The blood sample separates into two parts. centrifuge The top half is a straw coloured liquid called plasma. The bottom half is a dark collection of blood cells. If blood is separated it no longer looks like the red liquid that we recognise. 55% 45%

3. As blood is 55% plasma and only 45% cells, the cells are actually suspended within the plasma, a little like people would be suspended within a swimming pool. How a suspension works

4. Contents What is Blood? Plasma and cells in suspension Plasma functions Red blood cells White blood cells Blood cells Summary quiz

5. The plasma actually surrounds the cells and carries them along as it flows through the blood vessels. This is the first function of plasma. Blood flows around the body, transporting substances from one place to another. First function of plasma

6. it usually picks up a substance from an exchange site takes it to a place where it is used reaction a reaction occurs a useful product and a waste product is made Transport role

7. 7 of 50 The blood then transports one or both of these substances to another place in the body. useful/waste product cell blood vessel Shifting the product The cycle then starts again.

8. Products dissolved in plasma blood flowing along a capillary Blood has to rely on its plasma to transport some of these useful or waste products. For example, plasma carries CO 2 from the cells to the lungs. CO 2 plasma blood cell

9. The third and fourth roles are also centred around the moving of a substance from one place to another. Plasma is responsible for carrying dissolved food. Dissolved digestive products Our digestive system breaks down the food we eat to release the useful nutrients. Remember!

10. MouthAnus food is eaten waste is excreted Useful products of digestion are absorbed from the digestive system and enter the blood. Sugars Amino acids Glycerol Fatty acids Summary of absorption

11. The soluble food dissolves into the plasma and is carried from the small intestine to the cells of the body. Here they diffuse into the cells and are used in various chemical reactions. Leaving the plasma body cell sugars fatty acids glycerol amino acids plasma

12. The final role of the plasma is to carry a particular waste product from the liver to the kidneys. As urea is toxic, it must be removed from the body as quickly as possible! The blood now has to help the body do this. The waste product is called urea. Urea is made in the liver by the breakdown of amino acids. Removing urea

13. Plasma carries the urea from the liver to the kidneys that filter the blood. Urea is removed from the plasma of the blood and passes down a tube to the bladder. This urea in the bladder is stored before it is excreted. The urea will leave the body within the liquid urine. kidney blood urea Filtration and expulsion of urea

14. Reviewing the role of plasma

15. In summary, plasma has a principle role in transporting substances around the body. substance moving from going to CO 2 cells lungs Cellsall over the body Dissolved food small intestine cells Urealiver kidney Plasma – role summary

16. All this is being carried in just the plasma! fatty acids amino acids urea red blood cell carbon dioxide sugar white blood cell platelets The full load

17. Contents What is Blood? Plasma and cells in suspension Plasma functions Red blood cells White blood cells Blood cells Summary quiz

18. There are 3 types of blood cell within human blood. They have different shapes and carry out different functions. Red Blood Cells White Blood Cells (These are actually fragments of cells so we can’t really call them cells) Platelets Blood cells

19. red blood cells white blood cells platelets Image of the 3 constituents

20. Contents What is Blood? Plasma and cells in suspension Plasma functions Red blood cells White blood cells Blood cells Summary quiz

21. Of all the cells these are the most numerous. In fact, every cubic centimetre of blood contains… 1 cm 5 000,000,000 cells Red blood cells: erythrocytes

22. Therefore, it is not hard to realise that each red blood cell is extremely small. In fact, each one is only on average 7 micrometers in diameter (one micrometer is a millionth of a metre). This is a basic diagram of a red blood cell. Basic diagram of a red blood cell

23. Actually, although the red blood cell is a “cell”, it does not contain one of the 3 parts of a “normal” cell. Red blood cells have no nucleus. This may seem odd but, there is a reason for it. Inside the red blood cells Red blood cells also contain a unique substance called haemoglobin. This is a special iron based pigment whose presence is essential if the red blood cell is to perform its job. Fe 2+

24. The story begins in the lungs because this is where the oxygen gas enters the bloodstream. Remember, during the process of breathing, oxygen gas enters the body and is exchanged for carbon dioxide gas. The oxygen gas will be needed for the process of respiration. Red blood cells carry OXYGEN (O 2 ). Oxygen for carbon dioxide

25. O2O2 O2O2 O2O2 O2O2 oxygen is inhaled It passes through the breathing system and reaches an alveolus. The oxygen gas diffuses across the lining of the alveolus and the capillary. alveolus O2O2 O2O2 O2O2 O 2 diffusion

26. Here is a close up showing the diffusion of oxygen gas. As the oxygen gas diffuses across the lining of the alveolus, it dissolves in the moist layer. This speeds up the diffusion process. lining of alveolus moist layer red blood cell O2O2O2O2 O2O2O2O2 lining of capillary Inside the alveoli

27. If we now concentrate on one red blood cell, we can see how important the haemoglobin molecule is to the process of transporting oxygen. The oxygen molecule diffuses into the red blood cell. Haemoglobin + O2O2 each red blood cell contains the pigment... These two molecules bind together to produce this new substance. Oxyhaemoglobin

28. It is important to remember that this reaction is happening in red blood cells at the alveolus. This is how the red blood cells are able to bind hold of the oxygen and carry it within the blood. Each red blood cell is now loaded with oxygen molecules. Oxyhaemoglobin Oxygen binding at the alveolus

29. Order the following events

30. Once these red blood cells reach the cells of the body, they are travelling through tiny capillaries similar to those found in the alveolus. cells capillary It is here that they offload their oxygen. In order for this to happen, the oxyhaemoglobin molecule must be broken down. Offloading the oxygen to body cells

31. Oxygen diffusion at the capillary bed

32. In the cell, the oxygen is used in the process of respiration which produces…. The oxyhaemoglobin breaks down to release the oxygen molecule. It diffuses across the cell membrane and the lining of the capillary and into the cell. ENERGY Oxygen use in the body

33. 1 There are vast numbers of them. The more cells there are, the more O 2 can be carried and delivered to the cells. Features of red blood cells

34. 2 They have no nucleus. This means they have more room for haemoglobin molecules and therefore each red blood cell can carry more oxygen gas. Features of red blood cells

35. 3 They have a large surface area compared to their volume. small volume Through having a small volume compared to its surface area, the red blood cell is able to keep the oxygen close to its surface. Features of red blood cells large surface area

36. This means it can quickly release its oxygen by reducing the time it takes for the gas to diffuse out of the cell. The distance for the gas to move is much smaller in a cell shaped like this. O2O2 alternative cell design The overall effect of this means that the blood can cope with the oxygen demands of the body. Features of red blood cells O2O2

37. 4 The diameter of red blood cells is slightly larger than the average diameter of a capillary. This means that the red blood cell is forced to slow down as it passes through the capillary. This means the exchange of the gas will definitely happen. It also means the surface of the red blood cell will be exposed to the surface of the capillary. Features of red blood cells red blood cell capillary

38. Red blood cell features

39. Useful or useless?

40. Diffusion at the capillary bed level

41. Contents What is Blood? Plasma and cells in suspension Plasma functions Red blood cells White blood cells Blood cells Summary quiz

42. Let’s now consider the white blood cell. It has a much more varied shape and there are different types of white blood cell within the blood. The white blood cell is bigger than the red blood cell. White blood cell

43. White blood cells play a part in the defence system of the body. They are designed to fight microbes such as bacteria and viruses. There are far fewer white blood cells within the blood compared with red blood cells. Role in defence

44. When the body fights disease, more white blood cells are produced. With some diseases, doctors can establish how healthy someone is by testing their blood to see how many white blood cells they have. White blood cell count white blood cell number is higher test white blood cell number is low Disease

45. Match the cells to the correct functions

46. Blood cell differences

47. As we mentioned, the platelet is actually a fragment of a cell. Therefore it does not have a nucleus. They are also much smaller than both the white and red blood cells. Their role is to help to clot the blood when the body has a wound. cut skin Our final blood part is the platelet

48. Contents What is Blood? Plasma and cells in suspension Plasma functions Red blood cells White blood cells Blood cells Summary quiz

49. Multiple-choice quiz