1. Stone Varieties Adalyn Almora

2. Terms Nephrolithiasis- (kidney stones) is a disease affecting the urinary tract. Nephrocalcinosis-Calcifications within the parenchyma of the kidney

3. Calcium Calculi A. Calcium Calculi Calcium nephrolithiasis – urinary calcium urinary uric acid urinary oxalate level of urinary citrate Nephrocalcinosis - renal tubular acidosis and hyperparathyroidism.

4. 1. Absorptive hypercalciuric nephrolithiasis Secondary to increased calcium absorption from the small bowel (jejunum). results in an increased load of calcium filtered from the glomerulus. result is suppression of parathyroid hormone, decreased tubular reabsorption of calcium, culminating in hypercalciuria (>4 mg/kg).

5. Type 1 Absorptive hypercalciuria independent of diet Cellulose phosphate

6. Type 2 Absorptive hypercalciuria dietary dependent common cause of urinary stone disease.

7. Type 3 Absorptive hypercalciuria secondary to a phosphate renal leak serum phosphate 1, 25-dihydroxyvitamin D synthesis absorption of phosphate and calcium from the small bowel renal excretion of calcium Orthophosphate

8. 2. Resorptive hypercalciuric nephrolithiasis— Primary hyperparathyroidism present with nephrolithiasis. Parathyroid adenoma Inc.urinary phosphorus  decrease in plasma phosphorus,  inc in plasma calcium  decrease in urinary calcium. Hypercalcemia  renal damage limits the concentrating ability of the kidney and impairs the kidney’s ability to acidify urine.

9. 3. Renal-induced hypercalciuric nephrolithiasis— due to an intrinsic renal tubular defect in calcium excretion. Ca+2 excretion serum Ca+2 PTH Absorption Ca+2 in gut

10. 4. Hyperuricosuric calcium nephrolithiasis— dietary intake of purines endogenous uric acid production. elevated urinary uric acid levels >600 mg/24 h in women >750 mg/24 h in men

11. 5. Hyperoxaluric calcium nephrolithiasis— secondary to increased urinary oxalate levels (>40 mg/24 h) inflammatory bowel disease chronic diarrheal state

12. 6. Hypocitraturic calcium nephrolithiasis— Citrate = inhibitor Inc metabolic demands on the mitochondria of renal cells  dec. citrate intracellular metabolic acidosis fasting bacteria during a urinary tract infection.

13. B. NONCALCIUM CALCULI 1. Struvite— compose of MAP Women Proteus,Pseudomonas, Providencia, Klebsiella, Staphylococci, and Mycoplasma. pH (>7.19) MAP crystals precipitate.

14. 2. Uric acid— Men Gout, rapid weight loss Elevated uric acid levels are frequently due to dehydration and excessive purine intake

15. 3. Cystine— Inborn error of metabolism: abnormal intestinal (small bowel) mucosal absorption renal tubular absorption of dibasic amino acids, cystine, ornithine, lysine, and arginine. chromosome 2p.16 recently to 19q13.1

16. 4. Xanthine— Def. xanthine oxidase. catalyzes the oxidation of hypoxanthine  xanthine  uric acid

17. 5. Indinavir— most common protease inhibitor that results in radiolucent stones tannish red Indinavir calculi are the only urinary stones to be radiolucent on noncontrast CT scans.

18. 6. Rare— Silicate stones –antacids containing silica. Triamterene stones –radiolucent –with antihypertensive medications containing triamterene, such as Dyazide