1. Renal Pathology II, Case 2
A 63-year-old man presents with right flank pain that has been ongoing for the past several months

2. Identify the organ
Describe the gross findings
Identify the structures

3. A – Carcinoma
B - Ureter
Renal Cell Carcinoma
The surgical specimen consists of a whole kidney and attached ureter.
There is a large, irregular carcinoma in the superior pole of the kidney.

4. Identify the organ
Describe the gross findings
Identify the structures

5. A – Carcinoma
B – Normal Cortex
Renal Cell Carcinoma
The surgical specimen consists of a bisected kidney that contains a
renal cell carcinoma in the superior pole.
The large, irregular neoplasm is yellow to golden and contains areas of hemorrhage
(red). The yellow color and hemorrhage (increased vascularity) are characteristic
pathologic findings in a renal cell carcinoma.
Correlate the pathologic change with possible clinical presentations.

6. Describe the gross findings
Identify the structures.
Diagnosis?

7. A – Carcinoma
B – Normal cortex
C – Ureter
D - Aorta
Renal Cell Carcinoma
The autopsy specimen consists of a bisected left kidney,
normal right kidney (arrow) and attached aorta.
A renal cell carcinoma occupies the superior pole of the left kidney.
The neoplasm is yellow and contains extensive hemorrhage

8. Describe the low and high power histologic findings of sections
from the mass
Renal cell carcinoma, clear cell type
Tumor cells are rounded or polygonal shaped
with abundant clear or granular cytoplasm
(on special stains the cytoplasm stains for fat and glycogen).