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Influenza A/H1N1 W. Rose 20091026 H1N1 is a subtype of influenza type A Influenza types B and C also exist but less common, less infectious, and drift.

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Presentation on theme: "Influenza A/H1N1 W. Rose 20091026 H1N1 is a subtype of influenza type A Influenza types B and C also exist but less common, less infectious, and drift."— Presentation transcript:

1 Influenza A/H1N1 W. Rose 20091026 H1N1 is a subtype of influenza type A Influenza types B and C also exist but less common, less infectious, and drift less rapidly than type A Drift: gradual change in properties due to relatively rapid mutation rate (due to lack of proofreading of RNA polymerase product) Reassortment: combinations of genes from different viruses in a multiply-infected cell

2 Parts of virus Membrane with glycoproteins hemagglutinin (H), neuraminidase (N); ion channels (M2) Capsid (protein shell) Ribonucleoproteins (ssRNA, RNA polymerase, etc) http://medicineworld.org/images/blogs/9- 2006/influenza-virus-82101.jpg

3 Influenza A/H1N1 life cycle http://www.xvivo.net/zirus-antivirotics-condensed/ How it enters the cell What it does there How it reproduces

4 Influenza Vaccines Seasonal Flu Vaccine Mix of two A types, one B type Injectable: killed (inactivated) virus Nasal spray: live attenuated H1N1 2009 Flu Vaccine Injectable: killed (inactivated) virus Nasal spray: live attenuated Antiviral treatment Oseltamivir (Tamiflu), zanamivir (Relenza) : neuraminidase inhibitors, blocks viral budding from cell Amantadine etc.: blocks M2 ion channel, thus preventing uncoating; resistance common

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