1. PowerLecture: Chapter 21 Chromosomes and Human Genetics

2. Learning Objectives  Describe how an understanding of chromosomes helps to account for events that compose mitosis and meiosis.  Name some ordinary and extraordinary chromosomal events that can create new phenotypes (outward appearances).  Understand how changes in chromosome structure and number can affect the outward appear­ance of organisms.  Distinguish autosomal recessive inheritance from sex-linked recessive inheritance.

3. Learning Objectives (cont’d)  Explain how changes in chromosomal number can occur and present an example of such a change.  List examples of phenotypic defects and describe how each can be treated.  Explain how knowing about modern methods of genetic screening can minimize potentially tragic events.

4. Impacts/Issues Menacing Mucus

5.  Cystic fibrosis (CF) is a debilitating genetic disorder. Persons with two recessive genes Persons with two recessive genes will suffer from excessive accumulations of mucus in their lungs. The defective gene is located on The defective gene is located on chromosome 7 and codes for a membrane transport protein called CFTR.  Many thousands of prospective parents have been screened for CF; genetic testing, however, is not without controversy.

6. Useful References for Impacts/Issues The latest references for topics covered in this section can be found at the book companion website. Log in to the book’s e-resources page at www.thomsonedu.com to access InfoTrac articles.  Cystic Fibrosis Foundation  Cystic Fibrosis Foundation: Gene Therapy and CF  InfoTrac: Constant Battle: Kerri Marks Is One of the Survivors, Living Under a Disease’s Invisible Clock. Jennifer Becknell. Herald, July 10, 2006.

7. How Would You Vote? To conduct an instant in-class survey using a classroom response system, access “JoinIn Clicker Content” from the PowerLecture main menu.  Do we as a society want to encourage women to give birth only to offspring who will not develop serious gene-based medical problems? a. Yes, in order to prevent needless suffering and expense. a. Yes, in order to prevent needless suffering and expense. b. No, the diversity represented by special-needs children is important to a society. b. No, the diversity represented by special-needs children is important to a society.

8. Useful References for How Would You Vote? The latest references for topics covered in this section can be found at the book companion website. Log in to the book’s e-resources page at www.thomsonedu.com to access InfoTrac articles.  InfoTrac: Ohio Court Limits Relief for Fetal Testing Error; Compensation Denied for Costs of Raising Disabled Child. Judy Greenwald. Business Insurance, Mar. 13, 2006.  InfoTrac: In New Tests for Fetal Defects, Agonizing Choices for Parents. Amy Harmon. The New York Times, June 20, 2004.  InfoTrac: Offer All Pregnant Women Fetal Genetic Testing. Sherry Boschert. OB GYN News, Dec. 15, 1999.

9. Section 1 Genes and Chromosomes

10.  Understanding inheritance starts with gene- chromosome connections. Genes, the units of instruction for heritable traits, are segments of DNA arranged along chromosomes in linear order; each gene thus has its own locus. Genes, the units of instruction for heritable traits, are segments of DNA arranged along chromosomes in linear order; each gene thus has its own locus. Diploid cells have pairs of homologous chromosomes that are very much alike; homologues interact and segregate during meiosis. Diploid cells have pairs of homologous chromosomes that are very much alike; homologues interact and segregate during meiosis. Alleles are different forms of a gene; they often arise by mutation. Alleles are different forms of a gene; they often arise by mutation.

11. Genes and Chromosomes Independent assortment dictates that genes generally move into gametes independently of one another. Independent assortment dictates that genes generally move into gametes independently of one another. Crossing over leads to genetic recombination during meiosis. Crossing over leads to genetic recombination during meiosis.

12. Genes and Chromosomes  Closely linked genes tend to stay together when gametes form. When the distance between two genes on the same chromosome is very short, the genes are said to show linkage (they are “linked”); close genes generally travel together and are not segregated independently. When the distance between two genes on the same chromosome is very short, the genes are said to show linkage (they are “linked”); close genes generally travel together and are not segregated independently. Genes that are far apart on a chromosome will segregate independently as a result of crossing over between them. Genes that are far apart on a chromosome will segregate independently as a result of crossing over between them.

13. x ABab 50% AB50% ab meiosis, gametes form Closely linked genes in parents: Genes stay together in gametes. A B a b A B a b a b A B Fig. 21.1a, p. 388

14. Genes less likely to stay together as gametes form. x meiosis, gamete formation ACac A C A C A C a c a c A c a C a c Most gametes have parent’s genotype. A few gametes have recombinant genotypes. Fig. 21.1b, p.388 Weaker linkage in parents:

15. x ABab 50% AB50% ab Closely linked genes in parents: Genes stay together in gametes. A B A B a b a b meiosis, gametes form a b A B Fig. 21.1a, p. 388 Stepped Art

16. Genes less likely to stay together as gametes form. x ACac A C A C a c a c meiosis, gamete formation A C a c A c a C Most gametes have parent’s genotype. A few gametes have recombinant genotypes. Fig. 21.1b, p.388 Weaker linkage in parents: Stepped Art

17. Genes and Chromosomes  The X and Y chromosomes are quite different genetically. Sex chromosomes determine gender; males have one X and one Y chromosome while females have two X chromosomes. Sex chromosomes determine gender; males have one X and one Y chromosome while females have two X chromosomes. The X and Y chromosomes can synapse in a small region along their length, allowing them to behave as homologues during meiosis. The X and Y chromosomes can synapse in a small region along their length, allowing them to behave as homologues during meiosis.

18. Useful References for Section 1 The latest references for topics covered in this section can be found at the book companion website. Log in to the book’s e-resources page at www.thomsonedu.com to access InfoTrac articles.  Rocklin and Roseville Today: Genetic Behaviors Go Beyond X and Y Chromosomes  InfoTrac: Cord-Blood Storage Is Big Business, But Is It Worth It? Blythe Bernhard. Orange County Register (Santa Ana, CA), June 2, 2006.

19. Section 2 Picturing Chromosomes with Karyotypes

20.  A karyotype is a “picture” of a person’s chromosomes captured when the chromosomes have condensed to their metaphase (mitosis) state. Picturing Chromosomes with Karyotypes Figure 21.2f

21.  Cells are harvested from a patient, grown in the lab, and arrested in metaphase of mitosis (using colchicines) before the cells are disrupted and the chromosomes recovered.  Once photographed, the chromosomes are arranged in their homologous pairs and analyzed. Picturing Chromosomes with Karyotypes

22. © 2007 Thomson Higher Education b. Centrifugation Fig. 21.2(1), p.389 a. Add cells from a small blood sample c. Prepare cells d. Put cells on microscope e. Photograph cell

23. Animation: Karyotype Preparation CLICK TO PLAY

24. Useful References for Section 2 The latest references for topics covered in this section can be found at the book companion website. Log in to the book’s e-resources page at www.thomsonedu.com to access InfoTrac articles.  InfoTrac: Microarray Analysis of Cell-Free Fetal DNA in Amniotic Fluid: A Prenatal Molecular Karyotype. Paige B. Larrabee et al. American Journal of Human Genetics, Sept. 2004.

25. Section 3 How Sex Is Determined

26.  Sex is a question of X or Y. Gender of the human offspring is determined by the father’s sperm. Gender of the human offspring is determined by the father’s sperm. If an X-bearingIf an X-bearing sperm fertilizes an egg, the offspring will be female. If a Y-bearingIf a Y-bearing sperm fertilizes an egg, the offspring will be male. Figure 21.3a

27. X X Y X XX XY XX XY X X Y X x x eggssperm female (XX) male (XY) Fig. 21.3a, p.390 diploid germ cells in female meiosis, gamete formation in both female and male sex chromosome combinations possible in new individual

28. Animation: Human Sex Determination CLICK TO PLAY

29. How Sex Is Determined The Y chromosome has a “male-determining gene” (SRY) that codes for proteins that cause testes to form; in the absence of SRY, a female forms automatically. The Y chromosome has a “male-determining gene” (SRY) that codes for proteins that cause testes to form; in the absence of SRY, a female forms automatically. Nonsexual traits are also coded for on the sex chromosomes, mostly on the X. Nonsexual traits are also coded for on the sex chromosomes, mostly on the X. Genes that are specific to the X and Y chromosomes are called X-linked genes and Y-linked genes, respectively. Genes that are specific to the X and Y chromosomes are called X-linked genes and Y-linked genes, respectively. Figure 21.3b

30. appearance of “uncommitted” duct system of embryo at 7 weeks Y chromosome present Y chromosome absent penis testis ovary uterus vagina testisovary Fig. 21.3b, p.390

31. Y chromosome present Y chromosome absent testis penis uterus vagina Fig. 21.3b, p.390 testisovary appearance of “uncommitted” duct system of embryo at 7 weeks Stepped Art

32. Animation: Effects of the SRY Gene CLICK TO PLAY

33. How Sex Is Determined  In females, one X is inactivated. Most or all of the genes on one of the X chromosomes are switched off in early development, a process called X inactivation; which X becomes inactivated (maternal or paternal) is random. Most or all of the genes on one of the X chromosomes are switched off in early development, a process called X inactivation; which X becomes inactivated (maternal or paternal) is random. The inactivated X chromosome becomes condensed into a Barr body.The inactivated X chromosome becomes condensed into a Barr body. The female body is a mosaic of cells in which one or the other of the original pair of X chromosomes inherited from her parents is active.The female body is a mosaic of cells in which one or the other of the original pair of X chromosomes inherited from her parents is active.

34. How Sex Is Determined  Anhidrotic ectodermal dysplasia is a condition in females in which the active X chromosome in certain tissues carries a mutated gene that blocks the formation of sweat glands in patches of tissue over the surface of the body.

35. Fig. 21.4a, p.391

36. Useful References for Section 3 The latest references for topics covered in this section can be found at the book companion website. Log in to the book’s e-resources page at www.thomsonedu.com to access InfoTrac articles.  InfoTrac: The Genetic Legacy of the Mongols. Tatiana Zerjal et al. American Journal of Human Genetics, Mar. 2003.

37. Section 4 Human Genetic Analysis

38.  A pedigree shows genetic connections. The analysis of family pedigree charts provides data on inheritance patterns through several generations. The analysis of family pedigree charts provides data on inheritance patterns through several generations. Figure 21.5

39. Animation: Pedigree Diagrams CLICK TO PLAY

40. Human Genetic Analysis A person who is heterozygous for a recessive trait (carrier) may show the dominant phenotype but is still capable of passing the recessive gene on. A person who is heterozygous for a recessive trait (carrier) may show the dominant phenotype but is still capable of passing the recessive gene on. The term genetic abnormality is applied to a genetic condition that is a deviation from the usual, or average, but is not life threatening.The term genetic abnormality is applied to a genetic condition that is a deviation from the usual, or average, but is not life threatening. A genetic disorder is more appropriately used to describe conditions that cause medical problems.A genetic disorder is more appropriately used to describe conditions that cause medical problems. Syndrome refers to a set of symptoms that characterize a disorder by appearing together.Syndrome refers to a set of symptoms that characterize a disorder by appearing together.

41. Human Genetic Analysis  Genetic analysis may predict disorders. Genetic analysis, beginning with determination of the parental genotypes, is the first step to identifying any risks a couple may have in producing a child with a genetic disorder. Genetic analysis, beginning with determination of the parental genotypes, is the first step to identifying any risks a couple may have in producing a child with a genetic disorder. Figure 21.6

42. Human Genetic Analysis Not all factors leading to disorders can be readily quantified; it is important for prospective parents to recognize that each pregnancy will hold the same risks. Not all factors leading to disorders can be readily quantified; it is important for prospective parents to recognize that each pregnancy will hold the same risks.

43. Useful References for Section 4 The latest references for topics covered in this section can be found at the book companion website. Log in to the book’s e-resources page at www.thomsonedu.com to access InfoTrac articles.  GeneTests: Amish Lethal Microcephaly  InfoTrac: LCT Announces Results for Treating Huntington’s Disease. AsiaPulse News, Aug. 2, 2005.

44. Section 5 Inheritance of Genes on Autosomes

45. Inheritance of Genes on Autosomes  Inherited recessive traits cause a variety of disorders. Recessive inheritance is characterized by the following: Recessive inheritance is characterized by the following: Either parent can carry the recessive allele on an autosome.Either parent can carry the recessive allele on an autosome. Heterozygotes are symptom free; homozygotes are affected.Heterozygotes are symptom free; homozygotes are affected. Two heterozygous parents have a 50% chance of producing heterozygous children and a 25% chance of a homozygous recessive child. When both parents are homozygous, all children will be affected.Two heterozygous parents have a 50% chance of producing heterozygous children and a 25% chance of a homozygous recessive child. When both parents are homozygous, all children will be affected.

46. Inheritance of Genes on Autosomes Examples of autosomal recessive inheritance include: Examples of autosomal recessive inheritance include: Cystic fibrosis.Cystic fibrosis. Phenylketonuria (PKU), resulting from the abnormal buildup of phenylalanine due to the lack of an enzyme that normallyPhenylketonuria (PKU), resulting from the abnormal buildup of phenylalanine due to the lack of an enzyme that normally breaks it down. Tay-Sachs disease,Tay-Sachs disease, which affects primarily infants, is characterized by lack of an enzyme to break down lipids in the brain. Figure 21.7

47. Animation: Autosomal Recessive Inheritance CLICK TO PLAY

48. Inheritance of Genes on Autosomes  Some disorders are due to dominant genes. Inheritance of dominant alleles demonstrates the characteristics below: Inheritance of dominant alleles demonstrates the characteristics below: Because such alleles are usually expressed (even in heterozygotes), the trait appears in each generation.Because such alleles are usually expressed (even in heterozygotes), the trait appears in each generation. If one parent is heterozygous and the other homozygous recessive, there is a 50% chance that any one child will be heterozygous.If one parent is heterozygous and the other homozygous recessive, there is a 50% chance that any one child will be heterozygous. Dominant alleles, even if they cause severe genetic disorders, persist in the population due to mutation, nonreproductive effects, or post-reproductive onset.Dominant alleles, even if they cause severe genetic disorders, persist in the population due to mutation, nonreproductive effects, or post-reproductive onset.

49. Inheritance of Genes on Autosomes Examples of autosomal Examples of autosomal dominant inheritance include: Marfan syndrome resultsMarfan syndrome results from a defective form of fibrillin, found in connective tissue; one effect is to disrupt both structure and function of smooth muscle cells of the aorta. Figures 21.8 and 21.9

50. Inheritance of Genes on Autosomes Achondroplasia (dwarfism)Achondroplasia (dwarfism) results in heights of about 4 feet, but has no other serious effects; homozygotes, though, usually are stillborn. Familial hypercholesterolemiaFamilial hypercholesterolemia results in elevated levels of cholesterol due to few cell receptors for low-density lipoproteins. Huntington disease, a serious degenerative disease of the nervous system with an onset from age 30 onward; homozygotes always die, thus adults are always heterozygous.Huntington disease, a serious degenerative disease of the nervous system with an onset from age 30 onward; homozygotes always die, thus adults are always heterozygous. Figure 21.10

51. Animation: Autosomal Dominant Inheritance CLICK TO PLAY

52. Animation: Marfan Syndrome CLICK TO PLAY

53. Useful References for Section 5 The latest references for topics covered in this section can be found at the book companion website. Log in to the book’s e-resources page at www.thomsonedu.com to access InfoTrac articles.  InfoTrac: Geographic Distribution of Disease Mutations in the Ashkenazi Jewish Population Supports Genetic Drift over Selection. Neil Risch et al. American Journal of Human Genetics, April 2003.

54. Section 6 Inheritance of Genes on the X Chromosome

55.  X-linked recessive inheritance. X-linked recessive inheritance is demonstrated by the following: X-linked recessive inheritance is demonstrated by the following: The mutated gene occurs only on the X chromosome.The mutated gene occurs only on the X chromosome. Heterozygous females are phenotypically normal because a dominant gene on the other X chromosome masks the recessive’s effects; a male will be affected if he inherits a recessive gene on his sole X chromosome.Heterozygous females are phenotypically normal because a dominant gene on the other X chromosome masks the recessive’s effects; a male will be affected if he inherits a recessive gene on his sole X chromosome.

56. Inheritance of Genes on the X Chromosome A normal male mated with a female heterozygote together have a 50% chance of producing carrier daughters and a 50% chance of producing affected sons. In the case of a homozygous female and a normal male, all daughters will be carriers and all sons affected.A normal male mated with a female heterozygote together have a 50% chance of producing carrier daughters and a 50% chance of producing affected sons. In the case of a homozygous female and a normal male, all daughters will be carriers and all sons affected. Figure 21.11

57. Animation: X-Linked Inheritance CLICK TO PLAY

58. Inheritance of Genes on the X Chromosome Examples of X-linked recessive inheritance include: Examples of X-linked recessive inheritance include: Duchenne muscular dystrophy is a condition in which the protein dystrophin is missing, causing muscle fibers to weaken.Duchenne muscular dystrophy is a condition in which the protein dystrophin is missing, causing muscle fibers to weaken. Red/green color blindness is an inconvenience but is not life threatening.Red/green color blindness is an inconvenience but is not life threatening.

59. Inheritance of Genes on the X Chromosome Hemophilia A, where the inability of the blood to clot because the genes do not code for the necessary clotting agent (factor VIII) can lead to death from any cut or internal bleeding.Hemophilia A, where the inability of the blood to clot because the genes do not code for the necessary clotting agent (factor VIII) can lead to death from any cut or internal bleeding. Figure 21.12

60. Inheritance of Genes on the X Chromosome  Some types of X-linked abnormalities are quite rare. Faulty enamel trait is one of very few Faulty enamel trait is one of very few known examples of a trait caused by a dominant mutant allele that is X-linked; it is expressed in heterozygous females but is less pronounced than in males. Testicular feminizing syndrome (androgen insensitivity) is an abnormality of an XY individual in which a mutation in the X chromosome results in defective receptors for the male sex hormones; individuals have external female features, but no uterus or ovaries. Testicular feminizing syndrome (androgen insensitivity) is an abnormality of an XY individual in which a mutation in the X chromosome results in defective receptors for the male sex hormones; individuals have external female features, but no uterus or ovaries. Figure 21.13

61. Inheritance of Genes on the X Chromosome  Many factors complicate genetic analysis. Before diagnosing a case, geneticists often must pool many pedigrees and make detailed analyses of clinical data to keep track of instances where multiple mutations can lead to the same phenotype. Before diagnosing a case, geneticists often must pool many pedigrees and make detailed analyses of clinical data to keep track of instances where multiple mutations can lead to the same phenotype. As an example, some conditions can occur because of changes to autosomes or to the X chromosome. As an example, some conditions can occur because of changes to autosomes or to the X chromosome.

62. Useful References for Section 6 The latest references for topics covered in this section can be found at the book companion website. Log in to the book’s e-resources page at www.thomsonedu.com to access InfoTrac articles.  InfoTrac: Significant Improvement in Spirometry after Stem Cell Transplantation in One Duchenne Muscular Dystrophy Patient. Zhiping Li et al. Chest, Oct. 2005.

63. Section 7 Sex-Influenced Inheritance

64.  Sex-influenced traits either appear more frequently in one sex than the other or the phenotype differs depending on whether the person is male or female. Genes for such traits appear on the autosomes. Genes for such traits appear on the autosomes. Appearance of the trait may be due to the influence of sex hormones on gene expression. Appearance of the trait may be due to the influence of sex hormones on gene expression.

65. Sex-Influenced Inheritance  A male will develop pattern baldness if he is homozygous or heterozygous for a particular gene, but a female will develop the condition only if she is homozygous and then only late in life. Figure 21.14

66. Useful References for Section 7 The latest references for topics covered in this section can be found at the book companion website. Log in to the book’s e-resources page at www.thomsonedu.com to access InfoTrac articles.  InfoTrac: Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia. Axel M. Hillmer et al. American Journal of Human Genetics, July 2005.

67. Section 8 Changes in a Chromosome or Its Genes

68.  A gene mutation is a change to one or more of the nucleotides that composite a given gene.  Various changes in a chromosome’s structure may cause a genetic disorder.

69. Changes in a Chromosome or Its Genes A deletion is the loss of part of a chromosome due to breaks caused by viruses, chemicals, or irradiation. A deletion is the loss of part of a chromosome due to breaks caused by viruses, chemicals, or irradiation. Loss of a portion of chromosomeLoss of a portion of chromosome 5, for example, causes the disorder cri-du-chat. Normal genes on theNormal genes on the homologue can compensate for deleted genes. Duplication occurs when a gene sequence is repeated thousands of times. Duplication occurs when a gene sequence is repeated thousands of times. Figure 21.15

70. Animation: Deletion CLICK TO PLAY

71. Animation: Duplication CLICK TO PLAY

72. Changes in a Chromosome or Its Genes A translocation occurs when a part of one chromosome is transferred to a nonhomologous chromosome. A translocation occurs when a part of one chromosome is transferred to a nonhomologous chromosome. It is seen in some forms of cancer, such as whenIt is seen in some forms of cancer, such as when a segment of chromosome 8 is translocated to chromosome 14.

73. Animation: Translocation CLICK TO PLAY

74. Changes in a Chromosome or Its Genes A chronic type of leukemia is caused by an abnormally long chromosome 9 (Philadelphia chromosome), which is due to a piece of chromosome 22 that has become attached.A chronic type of leukemia is caused by an abnormally long chromosome 9 (Philadelphia chromosome), which is due to a piece of chromosome 22 that has become attached. Figure 21.17

75. Useful References for Section 8 The latest references for topics covered in this section can be found at the book companion website. Log in to the book’s e-resources page at www.thomsonedu.com to access InfoTrac articles.  Five P Minus Society: Family Support Group for Children with Cri du Chat Syndrome  BBC: Translocation  InfoTrac: Brazilian Researchers Connect Gene Mutation to Blood Conditions. Xinhua News Agency, June 20, 2006.

76. Section 9 Changes in Chromosome Number

77.  Several kinds of events can change the number of chromosomes in gametes. Aneuploidy is a condition in which the cells of an affected individual end up with one extra or one less chromosome than is the normal number. Aneuploidy is a condition in which the cells of an affected individual end up with one extra or one less chromosome than is the normal number. Polyploidy is a condition in which new individuals have three or more of each chromosome; it is lethal in humans. Polyploidy is a condition in which new individuals have three or more of each chromosome; it is lethal in humans.

78. Changes in Chromosome Number  Nondisjunction is a common cause of abnormal numbers of autosomes. Nondisjunction during mitosis or meiosis results in a change in chromosome number. Nondisjunction during mitosis or meiosis results in a change in chromosome number. If a gamete with an extra chromosome (n + 1) joins a normal gamete at fertilization, the diploid cell will be 2n + 1; this condition is called trisomy.If a gamete with an extra chromosome (n + 1) joins a normal gamete at fertilization, the diploid cell will be 2n + 1; this condition is called trisomy. If an abnormal gamete is missing a chromosome, the zygote will be 2n – 1: monosomy.If an abnormal gamete is missing a chromosome, the zygote will be 2n – 1: monosomy.

79. Animation: Nondisjunction CLICK TO PLAY

80. n + 1 n - 1 chromosome alignments at metaphase I nondisjunction at anaphase I alignments at metaphase II anaphase IIchromosome number in gametes Fig. 21.18, p.400

81. n + 1 n - 1 chromosome alignments at metaphase I nondisjunction at anaphase I alignments at metaphase II anaphase IIchromosome number in gametes Fig. 21.18, p.400 Stepped Art

82. Changes in Chromosome Number Down syndrome results from trisomy 21. Down syndrome results from trisomy 21. Trisomy 21 occurs in 1 outTrisomy 21 occurs in 1 out of 1,000 live newborns in North America; children will show some form of mental retardation, and 40% have heart defects. There is an increasedThere is an increased probability that a woman over age 35 will conceive an embryo with Down syndrome, yet 80% of trisomic infants are born to younger mothers simply because women ages 18-35 have more babies. Figure 21.19

83. Changes in Chromosome Number  Nondisjunction also can change the number of sex chromosomes. Turner syndrome involves females Turner syndrome involves females whose cells have only one X chromosome (designated XO). Turner’s individuals are sterile and haveTurner’s individuals are sterile and have other phenotypic problems such as premature aging and shorter life expectancy. Approximately 1 in 1,000 females are XXX; two of the Xs are condensed into Barr bodies, allowing normal development.Approximately 1 in 1,000 females are XXX; two of the Xs are condensed into Barr bodies, allowing normal development. Figure 21.20

84. Changes in Chromosome Number In Klinefelter syndrome, nondisjunction results in an extra X chromosome in the cells (XXY) of affected males. In Klinefelter syndrome, nondisjunction results in an extra X chromosome in the cells (XXY) of affected males. This occurs in about 1 outThis occurs in about 1 out of 500 live-born males and results in mild mental retardation and low fertility. XYY condition: XYY males XYY condition: XYY males result from nondisjunction of duplicated Y chromosomes during meiosis. Affected individuals are taller than average with normal phenotype.Affected individuals are taller than average with normal phenotype. Figure 21.20

86. Victims of Neurobiological Disorders  John Nash; Virginia Woolf Figure 21.21

87. Useful References for Section 9 The latest references for topics covered in this section can be found at the book companion website. Log in to the book’s e-resources page at www.thomsonedu.com to access InfoTrac articles.  InfoTrac: A Very Special Wedding. Claudia Wallis. Time, July 24, 2006.  InfoTrac: Common Age Misconception about Down Syndrome. PR Newswire, May 2, 2006.