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Detecting recent positive selection in the genome Wolfgang Stephan Abt. Evolutionsbiologie LMU München
Coalescent without recombination and selection Past Present Sampled gene copies T(2) T(3) T(4) T(5)
Two-locus model of genetic hitchhiking Selected locus Neutral locus A a A no recombinationrecombination A A a
Ancestral recombination graph with hitchhiking T = 0 (Present) T = neutral phase selective phase neutral phase T limit
Position (kb) Heterozygosity
Expected hitchhiking effect of a beneficial mutation Position (kb) Heterozygosity
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BIOL EVOLUTION AT MORE THAN ONE GENE SO FAR Evolution at a single locus No interactions between genes One gene - one trait REAL evolution: 10,000.
T HE E VOLUTION O F P OPULATIONS. E VOLUTION AND V ARIATION Microevolution- small scale evolution; change in allele frequencies in a population over generations.
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