We think you have liked this presentation. If you wish to download it, please recommend it to your friends in any social system. Share buttons are a little bit lower. Thank you!
Presentation is loading. Please wait.
Published byVanessa Pollard
Modified over 3 years ago
Detecting recent positive selection in the genome Wolfgang Stephan Abt. Evolutionsbiologie LMU München
Coalescent without recombination and selection Past Present Sampled gene copies T(2) T(3) T(4) T(5)
Two-locus model of genetic hitchhiking Selected locus Neutral locus A a A no recombinationrecombination A A a
Ancestral recombination graph with hitchhiking T = 0 (Present) T = neutral phase selective phase neutral phase T limit
Position (kb) Heterozygosity
Expected hitchhiking effect of a beneficial mutation Position (kb) Heterozygosity
Composite-likelihood ratio test (Kim and Stephan 2002)
Demographic model of D. melanogaster
wapl 6373103113 83 92 codingnon-coding (intergenic) EG:87B1.3Pgdbcn92 wapl Cyp4d1152A3.3 152A3.7/Cyp4d14 Cyp4d2 / Cyp4ae1 / pn / Nmd3 / CG17776 17E2.1 non-coding (Intron (>300 bp)) Positions in kb csw 23 13 Unc-76 03 EG:67A9.2 EG:22E5.4/ 22E5.9 D: (6 lines)
Models of Molecular Evolution III Level 3 Molecular Evolution and Bioinformatics Jim Provan Page and Holmes: Sections 7.5 – 7.8.
Topic #3 Linkage Disequilibrium, Haplotypes & Tagging
Dispersal models Continuous populations Isolation-by-distance Discrete populations Stepping-stone Island model.
Genomics An introduction. Aims of genomics I Establishing integrated databases – being far from merely a storage Linking genomic and expressed gene sequences.
Atelier INSERM – La Londe Les Maures – Mai 2004
Background The demographic events experienced by populations influence their genealogical history and therefore the pattern of neutral polymorphism observable.
Recombination and genetic variation – models and inference
Environmental Data Analysis with MatLab Lecture 15: Factor Analysis.
Credits to Vanessa Patel for some of the slides.
Human Mitochondrial Molecular Biology Center for Advanced Studies at Wheeler High School Post-AP DNA/Genetics.
Simon Myers, Gil McVean Department of Statistics, Oxford Recombination and genetic variation – models and inference.
Single Nucleotide Polymorphism And Association Studies Stat 115 Dec 12, 2006.
NEW TOPIC: MOLECULAR EVOLUTION.
Testing the Neutral Mutation Hypothesis The neutral theory predicts that polymorphism within species is correlated positively with fixed differences between.
A Little Intro to Statistics What’s the chance of rolling a 6 on a dice? 1/6 What’s the chance of rolling a 3 on a dice? 1/6 Rolling 11 times and not getting.
Coalescent Models for Genetic Demography
Islands in Africa: a study of structure in the source population for modern humans Rosalind Harding Depts of Statistics, Zoology & Anthropology, Oxford.
Biology and Bioinformatics Gabor T. Marth Department of Biology, Boston College BI820 – Seminar in Quantitative and Computational Problems.
Selectionist view: allele substitution and polymorphism
© 2017 SlidePlayer.com Inc. All rights reserved.