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Detecting recent positive selection in the genome Wolfgang Stephan Abt. Evolutionsbiologie LMU München.

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Presentation on theme: "Detecting recent positive selection in the genome Wolfgang Stephan Abt. Evolutionsbiologie LMU München."— Presentation transcript:

1 Detecting recent positive selection in the genome Wolfgang Stephan Abt. Evolutionsbiologie LMU München

2 Coalescent without recombination and selection Past Present Sampled gene copies T(2) T(3) T(4) T(5)

3 Two-locus model of genetic hitchhiking Selected locus Neutral locus A a A no recombinationrecombination A A a

4 Ancestral recombination graph with hitchhiking T = 0 (Present) T = neutral phase selective phase neutral phase T limit

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6 Position (kb) Heterozygosity

7 Expected hitchhiking effect of a beneficial mutation Position (kb) Heterozygosity

8 Composite-likelihood ratio test (Kim and Stephan 2002)

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11 Demographic model of D. melanogaster

12 wapl codingnon-coding (intergenic) EG:87B1.3Pgdbcn92 wapl Cyp4d1152A A3.7/Cyp4d14 Cyp4d2 / Cyp4ae1 / pn / Nmd3 / CG E2.1 non-coding (Intron (>300 bp)) Positions in kb csw Unc EG:67A9.2 EG:22E5.4/ 22E5.9 D: (6 lines)

13 Europe Africa

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