1. Nearly 5 Million Americans Have CHF 400,000 new onset cases diagnosed annually 1400,000 new onset cases diagnosed annually 1 Over 250,000 deaths annually 1Over 250,000 deaths annually 1 Over 3 times the number of breast and prostate cancer deaths combined 2Over 3 times the number of breast and prostate cancer deaths combined 2 Over 850,000 hospitalizations annually 1Over 850,000 hospitalizations annually 1 Incidence is growing 1Incidence is growing 1 1. American Heart Association; 1997 Heart and Stroke Statistical Update 2. American Cancer Society; Estimated New Cancer Cases and Deaths by Sex for All Site, United States, 1996

2. Prevalence by Gender and Age of CHF (NHANES Survey) Schocken DD, et al., J Am Coll Cardiol, 1992;20:301

3. Incidence of Hospitalizations for Heart Failure Third highest cause in all patientsThird highest cause in all patients Leading cause of hospitalizations in patients over 65Leading cause of hospitalizations in patients over 65 Approximately 35% of diagnosed heart failure patients are hospitalized per yearApproximately 35% of diagnosed heart failure patients are hospitalized per year National Center for Health statistics. Series 13, No. 108, 1989.

4. Readmission Rates Within 90 Days in Elderly Patients Vinson JM, et al., J Am Geriatr Soc, 1990;38:1290 First Admission

5. Readmissions for Elderly Patients For heart failure patients (>  70 years), multiple hospitalizations within six months are common. The 3-month readmission rate can be as high as 47%For heart failure patients (>  70 years), multiple hospitalizations within six months are common. The 3-month readmission rate can be as high as 47% Many readmissions for heart failure may be preventableMany readmissions for heart failure may be preventable Vinson JM, et al., J Am Geriatr Soc, 1990;38:1290

6. Calcium Channel Blockers Multicenter Diltiazem Post- Infarction Trial (MDPIT)* EF <40% *Subgroup analysis of patients with EF < 40% The Multicenter Diltiazem Post Infarction Trial Study Group N Engl J Med., 1988;319:385-92