1. Regulation of Gene Expression
Chapter 18
Regulation of Gene Expression
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2. Operon What elements from the following list constitute a bacterial operon?
structural gene(s)
repressor gene
promoter
operator
inducer
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3. Gene Regulation Each of a group of bacterial cells has a mutation in its lac operon. Which of these will make it impossible for the cell to metabolize lactose?
mutation in lacZ (β-galactosidase gene)
mutation in lacI (cannot bind to operator)
mutation in promoter (cannot bind polymerase)
mutation in operator (cannot bind repressor)
mutation in lacI (cannot bind inducer)
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4. When At which stages of gene expression are bacteria usually regulated
When At which stages of gene expression are bacteria usually regulated? Eukaryotes?
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5. Transcription Factors General transcription factors in eukaryotes are needed for all genes using the same RNA polymerase. What is the function of specific transcription factors? Of enhancers?
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6. Alternative Products A specific gene is known to code for three different but related proteins. This could be due to which of the following?
premature mRNA degradation
alternative RNA splicing
use of different enhancers
protein degradation
differential transport
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7. miRNA A given RNA transcript forms numerous hairpin loops that are cut (diced) to form short double-stranded non-coding sequences. How can these resulting strands affect gene expression?
Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings.

8. Developmental Regulation In the development of a multicellular organism, differential gene expression is responsible for both differentiation and sequential regulation. Write a plausible hypothesis for how one of these could occur in the formation of the heart.
Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings.

9. Embryo Formation Scientists showed that bicoid mRNA, and then its Bicoid protein, is normally found in highest concentration at the fly’s anterior. Predict what would happen if Bicoid were injected at the posterior end.
Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings.

10. Oncogenes Which of the following would not typically cause a proto-oncogene to become an oncogene?
gene suppression
translocation
amplification
point mutation
retroviral activation
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11. Multistep Cancer Causation How does the multistep model of colorectal cancer illustrate how an individual might inherit a “predisposition” for a particular type of cancer?
Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings.