Presentation on theme: "Nondisjunction Disorders. Down Syndrome (trisomy 21) 47, XX, +21 / 47, XY, +21 the result of an extra copy of chromosome 21 characteristic facial features,"— Presentation transcript:
Down Syndrome (trisomy 21) 47, XX, +21 / 47, XY, +21 the result of an extra copy of chromosome 21 characteristic facial features, short stature; heart defects, shorter lifespan often sexually underdeveloped and sterile, usually some degree of mental retardation Down Syndrome is correlated with age of mother but can also be the result of nondisjunction of the father's chromosome 21
Patau Syndrome (trisomy 13): 47, XY, +13 / 47, XX, +13 serious eye, brain, circulatory defects as well as cleft palate children rarely live more than a few months
Edward’s Syndrome (trisomy 18): 47, XX, +18 / 47, XY, +18 almost every organ system affected children with full Trisomy 18 generally do not live more than a few months.
Turner's syndrome (Monosomy X ): 45, XO the only viable monosomy in humans genetically female - they do not mature sexually during puberty and are sterile short stature and normal intelligence (98% of these fetuses die before birth)
Klinefelter’s Syndrome: 47, XXY genetically male individuals have male sex organs, but usually small testes and are sterile may have breast enlargement and other feminine body characteristics normal intelligence
Trisomic Females: 47, XXX healthy and fertile - usually cannot be distinguished from normal female except by karyotype
XYY Males: 47, XYY individuals are somewhat taller than average and sometimes have below normal intelligence increased amounts of acne normal sexual development