1. Bioinformatics Core Lang Li Center for Computational Biology and Bioinformatics Division of Biostatistics Department of Medicine

2. Bioinformatics Core Structure Analyst 1 Analyst 2 Analyst N Bioinformatics core (directed by Lang Li) Faculty 1 Faculty 2 Faculty N CCBB faculty Lab 1 Lab 2 Lab N … …… Bioinformatics Leader Microarray core(s) Proteomics core Sequencing core …

3. Research area covered by CCBB and Bioinformatics core Genetics – Population genetics – Pharmacogenetics Functional Genomics – Epigenetic regulation – Transcriptional regulation – Gene expression – Post-transcriptional regulation Proteomics/Metabolomics – Mass spectrometry data analysis – Protein structure prediction Drug screening Pharmacometrics – Pharmacokinetics – Pharmacodynamics – Disease models DNA Protein transcription translation mRNA Drug Lang Li Tatiana Foroud Jeesun Jung Shen Li Yunlong Liu Lang Li Changyu Shen Changyu Shen Jake Chen Yaoqi Zhou Keith Dunker Vladimir Uversky Samy Meroueh Lang Li Robert Bies

4. http://compbio.iupui.edu/

7. Sequence Analysis pipeline Primary analysisSecondary analysisTertiary analysis Image acquisition and bead processing Quality metrics Color calls Sequence alignment Sequence stats Consensus calling Create QC files Tag counting Application-specific analysis Re-sequencing De novo sequencing ChIP-seq Whole transcriptome DNA methylation … Sequencing CoreBioinformatics Core

8. High throughput data management caArray system is established at Bioinformatics core myTrack system for next generation sequencing data Manage, compare, share and publish high throughput data produced using next generation sequencing technology

9. Our team! Genetics/Genomics – Lang Li, Tatiana Foroud, Jeesun Jung, Shen Li Functional Genomics – Yunlong Liu, Lang Li, Changyu Shen Proteomics/Metabolomics – Changyu Shen and Jake Chen (high throughput technology) – Yaoqi Zhou, Keith Dunker, Vladimir Uversky (protein structure/disorder) Drug screening – Samy Meroueh Pharmacometrics – Lang Li, Robert Bies

10. Contact Info Lang Li, lali@iupui.edulali@iupui.edu http://compbio.iupui.edu/core