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Neural bases of recognition, priming and fluency Chris Berry UCL David Shanks UCL Rik Henson MRC-CBU.

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Presentation on theme: "Neural bases of recognition, priming and fluency Chris Berry UCL David Shanks UCL Rik Henson MRC-CBU."— Presentation transcript:

1 Neural bases of recognition, priming and fluency Chris Berry UCL David Shanks UCL Rik Henson MRC-CBU

2 According to one view the MTL drives recognition, but not priming and fluency (Conroy, Hopkins, & Squire, 2005) –The anterior MTL/perirhinal cortex is sensitive to recognition judgments (an explicit memory-strength/familiarity signal?) Does activity in the perirhinal cortex (and/or hippocampus) correlate with identification time, regardless of recognition judgment, or with recognition judgment, regardless of identification time? Does activity in perceptual/lexical/semantic neocortical regions correlate with identification time, regardless of recognition judgment? Recognition, priming and fluency ID time Recognition BOLD signal

3 ECHO 500 msec 1000 msec Clarification procedure 1500 ms 1. When you can identify the word say it aloud and then press a button msec Study Test Y / N ? 500 msec 1000 msec Clarification procedure 1500 ms 1. When you can identify the word say it in your head and then press a button 2. Make yes/no recognition judgment 400 msec 1600 msec studied 100 new ISI = 5s Event-related design Stimuli: 4-letter words Stimuli OldNew Judgment Old HitFalse alarm New MissCorrect rejection 100 trials ISI = 3.5s

4 Proposal 16 normal, healthy volunteers 200 studied, 200 new items ~= 50 mins EPI [2 x 25 min study-test sessions (6 min study-phase, 17 min test-phase)] Whole brain fMRI (TR = 3s, TE = 50 ms, 3 x 3 x 3 mm resolution) GLM in SPM - 5 regressors (RT & 4 trial types)


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