1. Congenital Perfusion Registry: Development and Current Status Brian Mejak, BS, CCP Children’s Hospital Colorado, Denver, Colorado Brian.mejak@childrenscolorado.org AmSECT 53 rd International Conference April 14-18, 2015 Marriott Tampa Waterside, Tampa Florida

2. Disclosures No off label usage discussed No financial disclosures

3. Development of the Pediatric PERForm Registry I.Areas of focus A. Anticoagulation management B. Circuit selection(equipment) for size of patient C. Prime constituents (packed RBCs, FFP, whole blood) D. Hematocrit and lactate values E. Modified ultrafiltration II.Inclusion criteria A. All surgical cases involving cardiopulmonary bypass III.STS database A. Can be linked to STS data set

4. Group assembled to develop registry Donny Likosky, PhD, U. of Michigan (PERForm founding father) Theron Paugh, CCP, U. of Michigan, Mott Children’s Hospital (PERForm founding father) Brian Mejak, Children's Hospital Colorado, Denver, CO Vince Olshove, Cedars-Sinai Medical Center, Los Angeles, CA Carmen Giacomuzzi, Doernbecher Children’s Hospital, OHSU, Portland, OR Tom Klein, Monroe Carell Jr Children’s Hospital at Vanderbilt, Nashville, TN Kathy Spitzer, Children’s Healthcare of Atlanta, Atlanta, GA James Reagor, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH Dan Gomez, Nationwide Children’s Hospital, Columbus, OH Rich Melchoir, Children’s Hospital of Philadelphia Richard Ginther, Children’s Medical Center at UT Southwestern, Dallas, TX

5. Pediatric Registry Fields I.Adult PERForm form was starting point A. Adult PERForm fields were reviewed individually by group members B. All additions, deletions, and comments were combined on one document II.All comments, additions, deletions were then discussed on conference calls III.Fields were tentatively finalized A. Six sections were created B. Each perfusionist in group was assigned a section C. Field selections and definitions from adult PERForm were updated to fit pediatric criteria i.e. All oxygenator brands/models were listed IV. Definitions were then reviewed and edited on conference calls.

6. Pediatric PERForm Data Form I.Developed in Excel format (Will not be final format) II.Emailed out to the 10 sites represented by the group A. Colleagues to complete and give feedback B. Clarity discussed on conference call and changes made

7. Areas of focus… Coagulation

8. Areas of Focus….Circuit Selection

9. Areas of Focus….Prime Constituents

10. Areas of Focus…Hct and Lactate, and MUF

11. Benefits of Joining I.Reports (Quarterly, Semiannual, Annual) I.Exchange of information through conference calls with participants showing data and discussing results. I.Exchange of information at the Pediatric Perfusion Conferences with participating center (data will be unblinded so exchange of information will be open and accessible)

12. Participation I.Cost- Yearly fee II. IRB A. University of Michigan will host data and has IRB B. Each individual will need IRB from their own institution to participate III.Software A. Fields will be part of STS software B. Separate web based browser