Presentation on theme: "Somatic Mutations in Cancer"— Presentation transcript:
1Somatic Mutations in Cancer This PowerPoint file contains a number of slides that may be useful for teaching of genetics concepts.You may use these slides and their contents for non-commercial educational purposes.
5The genetic basis of sporadic cancer Both alleles of a gene become inactivated in a particular somatic cell leading to loss of control of growth and unchecked cell proliferation.Clone of cancer cells from this one cell
6The genetic basis of the dominantly inherited familial cancer syndromes An altered allele is inherited and so is in all body cells containing genetic material. When the second (previously normal) allele of the gene pair becomes inactivated in a particular somatic cell this leads to loss of control of growth and unchecked cell proliferation.Second allele of the pair becomes inactivatedClone of cancer cells from this one cellInherited altered allele
7Mosaicism * mutation in single gene * chromosomal anomaly Mosaicism can be:somatic (ie in most body cells) orgonadal (confined solely to the gonads).
8Somatic mosaicism (eg trisomy 21) as a result of mitotic non-disjunction MitosisNon-disjunctionNormal disomyNormal disomyTrisomyMonosomy (lethal to cell)