Purines in the diet 1 DNA and RNA are highest in cells that are multiplying, tissues that are regenerating Mitochondria are most numerous in energy-producing cells (e.g. muscle) Mitochondria contain ATP and DNA
N N N N NH 2 O O (phosphate) 3 OH ATP energy purinergic signalling RNA, DNA cofactors (NAD etc) cAMP and AMP phosphate donor O O phosphate OH N N N N O IMP umami
Purines in the diet 2 DNA, RNA, nucleotides and bases are digested in the gut No purines are absorbed from the diet Uric acid is excreted directly from the gut (1/3) or via kidneys, in the urine (2/3)
Purines uric acid allantoin N N NHNH N NH 2 N N N O H H H O O H N N H O N N H H O H N O H X
uric acid N N N O H H H O O H N xanthine N N NHNH N O O Less soluble at acid pH Forms kidney stones if not excreted Excess may be deposited in joints and under the skin
uric acid allantoin N N N O H H H O O H N N H O N N H H O H N O H xanthine N N NHNH N O O ALLOPURINOL URICASE
Purine-rich meat, seafood and beer increase the risk of gout in men Choi et al, 2004: NEJM & Lancet Prospective 12-yr study of men aged 40 – 75, health professionals in USA 5.6% already had gout symptoms Of remaining 47,150 gout developed in 730, incidence of 1:1000 per year
The risk of gout in men Relative risk for meat-eaters 1.41; for high seafood consumption 1.51 Beer: RR 1.49 per 12oz/day No relationship to high-purine vegetables? Highest dairy intake, RR 0.56
Low-purine foods White bread Dairy products (milk, cheese, yogurt) Sugar and confectionery Most fruit and salad vegetables Fruit juices Water ? ? ? ?
Giles Corens dinner at Bonds, 5 Threadneedle Street Salad of smoked eel Roosters testicles on a bed of sweetbreads and kidney Sea bass with frog leg aïoli and 2 fritters of bone marrow Vegetables? Dessert? £100 for two without wine
Purines in the diet 3 Lower proportion of high-purine foods More dairy products (low fat!) Less fruit juice and fructose Smaller portion sizes More water – to dilute the urine
Your consent to our cookies if you continue to use this website.