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Chapter 19 ENDOCRINE SYSTEM 1. Compare the basic organization and function of the ES and the NS 2. Describe the structural and functional organization.

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Presentation on theme: "Chapter 19 ENDOCRINE SYSTEM 1. Compare the basic organization and function of the ES and the NS 2. Describe the structural and functional organization."— Presentation transcript:

1 Chapter 19 ENDOCRINE SYSTEM 1. Compare the basic organization and function of the ES and the NS 2. Describe the structural and functional organization of the hypothalamus and the pituitary and explain their relationship 3. Discuss the locations and structures of the thyroid, parathyroid, and adrenal glands as well as the thymus and the endocrine part of the pancreas. 4. List the hormones (and their function) produced by these glands. 5. Briefly review the results of abnormal hormone production

2 Endocrine System Overview Ductless glands produce hormones Ductless glands produce hormones Gland may be entire organ or interspersed bits of tissue Gland may be entire organ or interspersed bits of tissue Chemical classification of hormones Chemical classification of hormones Target tissues are identified by receptors Target tissues are identified by receptors

3 Hypothalamus Control Center for internal environment Regulates nervous and endocrine systems via 3 mechanisms: ANS centers exert nervous control on adrenal medulla ADH and Oxytocin production Regulatory hormone production (RH and IH) controls pituitary gland directly and all other endocrine glands indirectly Fig 19-3

4 Pituitary Gland (= Hypophysis) Structure: Infundibulum - connection to hypothalamus In the sella turcica Two parts with an embryonic double origin Posterior Pituitary = neurohypophysis Storage shed for ADH and Oxytocin (produced in ?) Anterior Pituitary Anterior Pituitary = adenohypophysis production of 7 peptide hormones, see fig 19.5 Anterior Pituitary Histology Fig 19-4

5 Hypophyseal Portal System Portal systems: two capillary networks in serial arrangement Advantage? Portal systems: two capillary networks in serial arrangement Advantage? Named after their destination:... Named after their destination:... Portal veins: blood vessels that link two capillary networks Portal veins: blood vessels that link two capillary networks Fig 19-6

6 Thyroid Gland n Anterior surface of trachea just inferior of thyroid cartilage (or Adams apple) n Two lobes connected by isthmus n Microscopic thyroid follicles produce thyroid hormone thyroid folliclesthyroid follicles n C Cells - produce calcitonin ( Ca 2+ ) Fig 19-7

7 Thyroid Gland Function Thyroxin (T4) and triiodothyronine (T3) speed up metabolic rate Calcitonin lowers blood Ca 2+ levels n n Thyroid pathologies: Hyper- and Hypothyroidism Goiter Exophthalmus

8 Hyperthyroidism Hypothyroidism Slowing of mind and body

9 Four Parathyroid Glands Parathyroid hormone (PTH; sometimes also called parathormone) Function: antagonist to Calcitonin Fig tiny glands embedded in the back of the thyroid (superior and inferior)

10 Thymus Gland Inside thoracic cavity immediately posterior to sternum above the heart Most active in infancy and childhood - Largest just before puberty Thymosin - enhances lymphocyte production and competence. (important for immune system)

11 Adrenal or Suprarenal Gland Cortex: aldosterone, cortisol, sexhormone Cortex: corticosteroid production aldosterone, cortisol, sexhormone Medulla: modified sympathetic ganglion produces adrenaline and noradrenaline ( parallels sympathetic division of ANS) Medulla: modified sympathetic ganglion produces adrenaline and noradrenaline ( parallels sympathetic division of ANS) Histology Histology Histology Fig 19-10

12 Pancreas Part of endocrine and digestive systems. (99% exocrine) Part of endocrine and digestive systems. (99% exocrine) Pancreatic islets or islets of Langerhans Pancreatic islets or islets of Langerhans Pancreatic islets Pancreatic islets cells: glucagon cells: glucagon ( blood sugar levels by stimulating liver to convert glycogen to glucose) cells: insulin cells: insulin ( blood sugar levels by causing the cells to take up glucose for use by the mitochondria) cells: somatostatin cells: somatostatin


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