1. Specialty Drug Benefit Management: Raymond Rupert MD. MBA. Rupert Case Management Inc.

2. Specialty Drugs Are Smart: Rituximab (Rituxin) by Roche can improve survivorship in lymphoma by 50% Smart drugs create fewer side effects

3. Specialty Drugs Are Costly: Average cost $65,000 per person per year Doctors using two or three biologicals at one time Problem: managing the rapidly escalating costs of specialty drugs

4. The Future Looks Expensive: 641 class D drugs licensed in Canada + 800 specialty drugs in the pipeline 35,000 patents in 2009 for specialty drugs

5. RCM’s Integrated Service: RCM manages the total specialty drug benefit from start to resolution for TPAs, benefits consultants insurers drug plans or employers

6. RCM’s “Lean On Me” Service: This service provides the client with a: –Mentor –Advisor –Medications Expert –Purchasing agent –Logistics manager –Confidante and –Friend

7. OUR NEIGHBOURHOOD: Customer Rx Clinical Plan review RCM Treatment review Treating doctors Clinical researchers Case conference Top DOCS Determine Tx options Evidence based report Alternatives Genetic marker testing siRNA Clinical trials Prior authorization Finalize Rx Purchase Distributors Suppliers Infusion centers Cold chain Competitive sourcing Coordination of benefits Coordination of care Monitoring/Aftercare Employer funding PAP Private funding Public funding Other sources

8. Gord’s Case Study: Gord is a 60 year old business person Leukemia + Non-hodgkins lymphoma Rituxin from Roche was advised Not eligible for the provincial plan Coverage with his private drug plan Infusion issue in hospital Outcome: 50% improvement in survival

9. RCM’s Enhanced Customer Experience: Clarity in communications Decision support that is impactful Guidance that is relevant Effective advocacy Emotional support Engagement of patient + family

10. RCM Provides Decision Support Audit the clinical situation Review the treatment plan Source second opinions if required Invites outside experts to a virtual case conference Keeps patient fully informed

11. Pharmacogenomic Testing: RCM arranges tests for genetic variation Determine if drug will work and ensure that side effects will be minimized HER2 test with Trastuzumab (Herceptin) K-RAS test with Cituximab (Erbitux) EGFR test with Gefitinib (Iressa)

12. Option of Clinical Trials: RCM tracks clinical trials Understands the entry criteria Assesses the design Blinded Unblinded Placebo group Completes the paper work Ready with Plan B, C, D if rejected

13. RCM’s Job One: Ensure Appropriate Utilization: RCM ensures that: The right person Gets the right medication For the right indication At the right dose At the right time Through right route At the right price For right length of time

14. Many Possible Funding Sources: RCM can seek public or private funding RCM uses patient assistance programs Access pharma company sponsorship Access employer funding on an exception basis

15. Co-ordination of Benefits: Careful juggling of benefits practiced here!

16. RCM Monitors Compliance + Adherence: RCM monitors if the drug is being used properly to achieve the best possible outcome for the cost incurred

17. RCM Delivers Lowest Cost Sourcing: RCM seeks the lowest cost product using competitive sourcing RCM understands “off label” indications Different products with same benefit sold at markedly different price points

18. Realize Cost Savings: Treatment of macular degeneration Use Lucentis $2000 per treatment Or use Avastin at $100 per treatment Savings for the drug plan of $1900 per treatment with RCM’s benefit management

19. RCM’s Client Monitoring: RCM provides monitoring and aftercare for as long as is needed

20. Benefits Of Retaining RCM: 1. Lower costs for the employer + the plan Improve the sustainability of the plan Delivery of performance metrics 2. Seamless transitions 3. Continuity of care 4. Enhanced customer experience 5. Hopefully better outcomes 6. Enhanced employee loyalty

21. To Learn More About RCM’s Specialty Drug Benefit Management: Call- 800 620 7551