1. Ultrasound Elastography: Prostate Cancer Detection Assessment Using A Phantom Brett Coelho Medical Biophysics 3970Z March 26, 2013

2. Introduction  Prevalence and Early Detection  Ultrasound Elastography  Specificity and Sensitivity B-mode Prostate Image

3. Introduction  Stiffness  Strain Images B- mode ImageStrain Image

4. Methods  Hooke’s Law  Young’s Modulus Reconstruction: Iterative

5. Methods  Phantom Construction Phantom Ingredients

6. Methods  Preparing Phantom Solutions  Gelatin – 70  Agar – 80  Formaldehyde – 90  Glycerol – 90  Sigma Cell  Cool Down

7. Methods  Pouring The Moulds Prostate and Surrounding Tissue MouldsTumor Moulds

8. Methods Pouring The Moulds Prostate and Sample Moulds

9. Methods  Uniaxial Test Uniaxial Testing Machine and Cylindrical Sample

10. Methods  Ultrasound Circular Ultrasound Array Linear Array

11. Methods  Strain Images Strain Imaging

12. Results  Uniaxial Results  Ratios Ep/Es=5.4  Et1/Es=8.7  Et2/Es = 9.3 Strain Stress kPaStress kPa

13. Results  Post Processing  Elastic Moduli Reconstruction Strain Image Frames

14. Results  Post Processing  Ep/Es=2.2  Et1/Es=6.0  Et2/Es=8.9 Phantom Tissue Manual Selections

15. Results  Tumour Mis Allocations  TM1=5.21  TM2=5.68 Reconstructed Image Tumor Locating B-mode Image Tumor Locating

16. Conclusions  Comparing the ratios  Tumor Misallocations

17. Sources of Error  Strain Images  Uniaxial Test  Assumptions for Stress Calculation

18. Future Research  Improve Detection and Modulus Calculations  Computational Time  Assumptions and Meshing

19. Acknowledgements  Dr. Samani  Reza Mousavi  Thank you!