2. Vision and Aims Chalmers AoAs should use our scientific excellences to meet the global grand challenges where we can make a difference The AoAs aims to coordinate establishment of excellent cross-disciplinary research. The AoAs contribute to meet societal requirements to integrate research, education and innovation and to establish new arenas between academia, industry and society. Hereby the AoAs contribute actively to reaching Chalmers overall objective to address global challenges in order to establish a sustainable society The AoAs should together with the departments develop: Excellent research environments Integration of research, education and innovation Research infrastructures Strategic collaboration with industry Chalmers brand

3. Synthetic Biology Systems Biology Food Processing and Quality BioNano Technologies Bioinformatics Evolution and Population Dynamics Network Analysis Enzyme Technology Biopharmaceuticals and Nutraceuticals Biofuels and Biochemicals Nutritional Biotechnology Bioavailability Bioactive Compounds in Foods Biomedical Imaging Biomedical Engineering Kinetic Models BASIC SCIENCE LIFE SCIENCE ENGINEERING OVERVIEW EXCELLENCE PROFILES ACTIVE FIELDS Morphogenesis Biorefineries Biomaterials E-health Bioanalytics and Biomolecular Imaging Pharmaceutical Biochemistry

4. Molecular and Chemical Biology (Andrew Ewing) Mathematical Biology (Torbjörn Lundh) Fermentation Technology (Lisbeth Olsson) Food & Nutrition (Ann-Sofie Sandberg) Human Health Biology Ind. Biotech Management Group Profile leaders + 1 young faculty + 1 PhD student + director for research school + innovation rep. + FCC rep. + OSS rep. Management Group Profile leaders + 1 young faculty + 1 PhD student + director for research school + innovation rep. + FCC rep. + OSS rep. AoA Director Jens Nielsen AoA Director Jens Nielsen AoA Coordinator Martin Markström AoA Coordinator Martin Markström Bioengineering (Mikael Persson) Active Fields ORGANIZATION

5. Human Metabolic Atlas Clinical Data (serum chemistry, tissue specific data,.) Clinical Data (serum chemistry, tissue specific data,.) BiomarkersAnalysis & visualization Tissue specific models Databases Circulatio n model Metabolic simulations Drug development External Databases & Clinical Data Human Metabolic Atlas: The Vision The Atlas will be an interactive database and modeling infrastructure that can be used for enriching the value of clinical data

6. Reconstruction of Cell Type Specific Models 6 PLoS Comp. Biol. (2012) 8:e1002518

7. Human Metabolic Atlas Mapping of metabolism in 69 different human cell types

8. Personalized GEMs for Liver cancer The presence/absence of enzymes encoded by 2,989 genes present in HMR were evaluated and the proteome data is heterogeneous between the patients. Strong Moderate Weak Negative PATIENT IDSEXAGELIVER CANCER TYPE Patient 2279Female73CholangioCarcinoma Patient 2399Female52CholangioCarcinoma Patient 3625Male59CholangioCarcinoma Patient 3334Male67CholangioCarcinoma Patient 2556Male72HepatocellularCarcinoma Patient 2766Female73HepatocellularCarcinoma Patient 2177Female58HepatocellularCarcinoma Patient 3196Male65HepatocellularCarcinoma Patient 3477Male67HepatocellularCarcinoma Patient 2280Male80HepatocellularCarcinoma Patient 2177 Patient 3477 Patient 2766 Patient 3196 Patient 3334 Patient 2280 Patient 3625 Patient 2556 Hepatocytes Patient 2279 Patient 2399 8

9. Gut metagenomic study in patients with atherosclerosis 9 Nature Comm. (2012) 3:1245

10. Glucose Sucrose Galactose Xylose Fine chemicals Biofuels Commodity chemicals Protein drugs Volume Value Butanol Biodiesel 3-HPA Succinic acid Sesquiterpenes Antibiotics Human insulin S. cerevisiae Synthetic Biology Systems Biology Bio-Based Production of Fuels & Chemicals We are developing yeast cell factories for the production of advanced biofuels and different chemicals

11. Nutragenomics and Food Science We are evaluating the role of bioactive food components using a systems biology

12. Biomedical Engineering We are developing advanced diagnostic tools, e.g. to identify stroke using microwave analysis