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Genetic Mutations Any change in the DNA base sequence is called a mutation.

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Presentation on theme: "Genetic Mutations Any change in the DNA base sequence is called a mutation."— Presentation transcript:

1 Genetic Mutations Any change in the DNA base sequence is called a mutation

2 Why is the Tiger White DNA mRNA protein Mutations are changes in the genetic code Some changes are lethal, and some dont matter at all. (This tiger is white because of a genetic mutation)

3 Mutations in gamete cells mutation passed on to offspring Mutations in body cells damage to a gene = cell malfunction. New cells will also have malfunction

4 How do Mutations happen? Mutations: good, bad or neutral- most often neutral Spontaneous Nuclear radiation Ultraviolet light- sunlight Chemicals Mutagen- causes mutations

5 Decode this sequence mRNA ACU– GGA – CCA -- UUC Protein ____ _____ ____ ____ threonine glycine proline phenylalanine Now change just the last C to a G What do you get? leucine

6 A change of one base is called a point mutation mRNA ACU– GGA – CCA -- UUC threonine glycine proline phenylalanine Change the last C to a U- what happens? Sometimes point mutations dont matter

7 Insertions and Deletions are Frameshift mutations mRNA ACU– GGA – CCA -- UUC Take out the first C AUG-- GAC– CAU– UC Meth ASP Hist ??? Called Frame shift mutations

8 Mutations Point mutations (substitutions)- may or may not be a big deal Frame shift mutations (insertions or deletions)- always a big deal

9 Example of a point mutation Sickle cell anemia One base change- one amino acid substitution Hemoglobin does not function normally


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