1. 1 EU-funded health research activities against TB: FP6 actions and perspectives toward FP7 DG Research - European Commission 22 MARCH 2007

2. 2 FP6 Tools and Instruments Project funding: focus on product development pipeline  Large consortia: basic and preclinical research up to early human testing (10 M€ / 10+ partners / 5 y) Number of TB Projects: 3  Small-scale, high risk projects (1-2 M€ / 2-3 years / young researchers/ SMEs) Number of TB Projects: 19 Programme funding: EDCTP  Focus on phase II-III clinical trials  Coordination of national research programmes on PRDs  Independent legal entity Strategy for Poverty Related Diseases (PRD)

3. 3 Overall Research Strategy of the 6 th Framework Programme to confront HIV/AIDS, Malaria and Tuberculosis Pre-clinical Discovery Genomics Vaccines (NoE) Microbicides (IP) Therapy Trials in Europe Drugs (IP) Vaccines (IP/NoE ) Biology and Pathology (NoE) EUROPEAN DEVELOPING COUNTRIES CLINICAL TRIALS PARTNERSHIP (EDCTP) Clinical Trials (Phase II/III) HIGH RISK PROJECTS (STREPS) DEFINED SUPPORTING ACTIVITIES (SSA) Vaccines (IP) Drugs (IP) HIV/AIDSMalariaTB CROSS-CUTTING TOPICS: Mucosal vaccines for PRD (IP) Neonatal vaccination strategies for PRD Early human testing SOME STRUCTURING CAs, SSAs ? NEW INSTRUMENTS

4. 4 Distribution of EC funding to PRD during FP6 (2002-2006) TB funding: 61 M€ DiscoveryTranslational research Clinical (incl. EDCTP) Total (%) 87 M€ (19%) 134 M€ (29%) 237 M€ (52%) 458 M€ (100%) (EDCTP not included)

5. 5 FP7 2007 –2013 Specific Programmes Ideas – Frontier Research Capacities – Research Capacity People – Marie Curie Actions Cooperation – Collaborative research

6. 6 Cooperation: Collaborative research in FP7 Thematic Priorities 1.Health 2.Food, agriculture, fisheries and biotechnology 3.Information and communication technologies 4.Nanosciences, nanotechnologies, materials and new production technologies 5.Energy 6.Environment (including climate change) 7.Transport (including aeronautics) 8.Socio-economic sciences and the humanities 9.Security 10. Space

7. 7 Collaborative research in the Health theme Main policy drivers:  Improving health of European citizens  Increasing competitiveness of European health- related industries and businesses  Addressing European and global health issues, including emerging epidemics Budget:  €6.1 billion over 7 years (2007-2013)

8. 8 First calls of FP7  1st FP7 workprogramme: 22 Dec 2006  Deadline 1: 19 April 2007  Deadline 2: 18 September 2007

9. 9 Infectious Diseases: Continuity of Challenges in FP7 Longer duration - larger budget Continuity from FP6 (pipeline approach) Focus on product development Focus on collaborative research Focus on global health problems Create Partnerships Between scientists from different disciplines Between scientists from different countries Between different sectors: Industry-academia

10. 10 Topics from first calls Health HIV/AIDS, malaria and tuberculosis (1) Topics for first call (19 April 2007): Highly innovative approaches for research into host-pathogen interaction in tuberculosis (FRP). Development of fast tests for the diagnosis of Multi-Drug-Resistant strains of HIV, malaria and tuberculosis and of latent tuberculosis infection (LTBI) (FRP). Paediatric formulations of drugs against HIV/AIDS, malaria and tuberculosis (CA or SA).

11. 11 Topics from first calls Health HIV/AIDS, malaria and tuberculosis (2) Topics for second call (18 September 2007): European network for study and clinical management of TB drug resistance (IP) SICA topics for second call (18 September 2007): Highly innovative research in HIV/AIDS, malaria and tuberculosis between Indian and European partners. Targeted Region: India. Other ICPCs are also encouraged to join (FRP). Coordination of European research activities with global initiatives, including Public-Private Partnerships. Targeted Regions: ICPC (CA or SA). Next generation of researchers for HIV/AIDS, malaria, tuberculosis and neglected infectious diseases. Targeted Regions: ICPC (CA or SA). ICPC: International Cooperation Partner Countries

12. 12 Information & useful addresses National Contact Points: www.cordis.lu/fp6/lifescihealthwww.cordis.lu/fp6/lifescihealth ERC webpage: http://erc.europa.euhttp://erc.europa.eu The Health Directorate – Director: Dr O. Quintana-Trias: octavi.quintana-trias@ec.europa.eu TB research: Hannu Lång: hannu.laang@ec.europa.eu Infectious Diseases unit http://ec.europa.eu/research/health/poverty- diseases/index_en.html Framework Programme 7: http://cordis.europa.eu/fp7