1. Author: Coroiu Costel Coordinators: Molnar Calin MD, PhD Saracut Claudiu MD, PhD Student Co-authors: Simion Ioachim-Iustinian,Ion Razvan- Marius, Macec Adelina, Goidescu Alina-Olimpia

2. colorectal cancer is a disease that affects more and more people and is the second cause of death after lung cancer in male population and the third cause of death after breast cancer and cervical cancer in female population. Over 700.000 deaths worldwide render the importance of clinicopathological studies. The evolution of the methods of investigation, diagnosis and treatment in the last few years provides a better way to prevent and treat the colorectal cancer. [1-colorectal cancer]

3. The main purpose of our study is to observe the incidence and characteristics of colorectal cancer among patients diagnosed in the Surgery Clinic 1 of Tirgu Mures County Emergency Hospital. The subsidiary purposes are: to observe some aspects and differences between patients with colorectal cancer and patients with gallbladder disorders and colorectal cancer and to use the results as a ground base for future statistical studies.

4. You can not change:age, inherited conditions and syndroms, personal history of inflammatory bowel disease, colorectal cancer or family history of colorectal cancer or adenomatous polyposis Life-style related factors:diets with red meat, obesity, smoking, alcohol abuse Another risk factor is gallbladder disorders like cholelithiasis or a cholecystectomy in the pathological history of the patient. 2-FAP 3-red meat

5. This is a retrospective study undertaken between 2003 and 2013 on 1005 patients who were hospitalized in the Surgery Clinic 1 of Tirgu Mures County Emergency Hospital. From 1005 cases we selected the ones only with colorectal cancer and we excluded the patients with anal canal cancer. Using their records and histopathological bulletins, we analysed cancer location, sex distribution, frequency by years, histologic and macroscopic forms and we observed some correlations between location and symptoms. To complete the study, we used some statistical instruments, such as GraphPad and Microsoft Excel. We focused our study on patients with colorectal cancer, 939 cases, from which 167 were having gallbladder disorders.

6. Transverse colon includes liver flexure and splenic flexure

7. with a P<000.1

11. The number of colorectal cancer cases increases year by year. The first role in defeating the rising number of colorectal cancer cases should be assumed by the medical staff through different informing, screening and diagnosing campaigns. According to our study, from 939 patients, a percentage of 17.78, which means a number of 167 patients, had gallbladder disorders and this should raise questions over the correlation of gallbladder disorders and colorectal cancer, which means that more studies should be performed in this direction.

12. Our collected data may be used as a data base for next studies. But the main obstacle of our study was the limited access to patients records and the fact that most of the records were incomplete.

13. 4-cancer classification 5-cancer stagies

14. 1)http://flplahore.blogspot.ro/2012/10/www.distributorpakistan.co m_5.html 2) http://www.colorectaltumor.com/p/familial-adenomatos.html 3) http://www.seattleorganicrestaurants.com/vegan-whole- foods/red-meat/ 4)http://www.hopkinscoloncancercenter.org/CMS/CMS_Page.aspx? CurrentUDV=59&CMS_Page_ID=EEA2CD91-3276-4123-BEEB- BAF1984D20C7 5)http://www.bowelcanceraustralia.org/bca/index.php?option=co m_content&view=article&id=148&Itemid=301