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Chapter 2: Cognitive Neuroscience

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1 Chapter 2: Cognitive Neuroscience

2 Some Questions of Interest
What are the fundamental structures and processes of the human brain? How do researchers study the major structures and processes of the brain? What have researchers found as a result of studying the brain?

3 Anatomy of the Brain

4 Anatomy of the Brain Forebrain Cerebral cortex Basal ganglia
Motor movement Limbic system

5 Anatomy of the Limbic System
Septum & Amygdala Involved in anger, aggression, fear Hippocampus memories Thalamus Relays sensory information to the cerebral cortex Hypothalamus 4 F’s Korsakoff's syndrome presents symptoms of severe anterograde and retrograde amnesia, as well as confabulation.

6 Midbrain Helps to control eye movement and coordination
Reticular activating system Controls respiration, cardiovascular function, digestion, alertness, and sleep Brain stem Vital in basic attention, arousal, and consciousness

7 Hindbrain Medulla Oblongata Pons Cerebellum
Breathing, swallowing, and digestion Pons Relay station Cerebellum Motor coordination, posture, and maintaining balance

8 Lobes of the Cerebral Cortex
Lobes of the Cerebral Cortex

9 Cerebral Cortex Contralaterality Corpus Callosum
Neural fibers connecting left and right lobes Allows communication between right and left side

10 Cerebral Cortex: localization and specialization

11 Hemispheric Activity Interferes With Ability to Work a Counter
Demo from activiities

12 Specialization of Left Hemisphere
Wernicke’s area vs. Broca’s area

13 Split-Brain Demonstration
Split-brain patients are asked to stare at the black dot in the middle of the screen. Two different images are displayed simultaneously to each side of the brain. Information about the wrench is on the left side, so would be processed by the right side of the brain which controls the left hand, thus a split-brain patient would point to a wrench. The apple is on the right side and so would be processed by the left side of the brain which controls language so the patient will say apple. Sperry ( ) First to study patients with a split corpus callosum Two lobes function independently Gazzaniga (1980s-current) Two lobes function complementarily What would a split-brain patient say they saw? What would a split-brain patient point to with their left hand?

14 Brain Disorders Capgrass syndrome Phantom limb Synesthesia

15 Structure of a Neuron The shape of a neuron is determined by its function. Each neuron, however, has the same structure: soma, dendrites, an axon, and terminal buttons. Use image to discuss neuronal communication.

16 Neurotransmitters Chemical messengers
Acetylcholine = associated with Alzheimer’s disease Dopamine = associated with schizophrenia and Parkinson’s disease Serotonin = associated with anorexia

17 Group Reaction Time and Neural Speed

18 Viewing Structures and Functions of the Brain

19 Animal Studies Single-cell recordings Selective lesioning
Genetic knockout procedures Create animals that lack certain kinds of cells or receptors in the brain Describe the single neuron technique using image and corresponding action potentials such as the example of In Vivo research. Single neuron and the corresponding action potentials image created and used with permission by: Patricio O'Donnell, MD, PhD Professor of Neuropharmacology & Neuroscience Albany Medical College 47 New Scotland Ave. Albany, NY

20 Human Studies Electrical recordings Event-related potential (ERP)
At left, some data collected from adult subjects for a collaborative project between myself and Dr. Meg Moulson highlighting typical "Face-sensitive" components of the ERP signal at the "N170.” Balas Lab NDSU

21 Human Studies Static imaging techniques Angiogram CT scan; MRI scan

22 Metabolic Imaging Positron emission tomography (PET)
Radioactive material is injected or inhaled Participant is then scanned to produce an image of the brain’s activity INSERT FIG 2.10 (d)

23 Metabolic Imaging Functional magnetic resonance imaging (fMRI)
Takes a series of images of the brain in quick succession Brain areas with more blood flow have been shown to have better visibility No X-rays or radioactive material is used. Provides detailed view of the brain in different dimensions.

24 Metabolic Imaging Transcranial magnetic stimulation (TMS)
Temporarily disrupt functioning of a particular brain area An electrical current passes through a coil on person’s head, generating a magnetic field

25 Metabolic Imaging (MEG) Magnetoencephalography
Measures activity of the brain from outside the head by picking up magnetic fields emitted by changes in brain activity

26 Brain Disorders Stroke Brain tumor Head injuries


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