1. Is Cancer a Disease of Self-Seeding? Larry Norton Joan Massagué presented by: Giulia Dulá and Alina Gatowski

2. Current Understanding Aberrant Migration Invasion Metastasis Increased proliferation: cell death Dichotomies Invasion vs. metastasis Tumorigenesis vs. metastatic behavior

3. What is self-seeding? Cell mobility is key for primary tumor growth (not just metastasis) Think about weeds in a field: NOT by one plant growing large Continuous growth of new weeds within original site and at periphery

4. The logic of self-seeding

5. Mathematics of self-seeding Fractal geometry Gompertzian growth

6. How does self-seeding fit current understanding? Increased growth rate and increased total volume of malignancy Satellite lesions Larger tumor mass cell density Aggressive seeding could be cause for large tumor masses with high metastatic potential