1. doc.: IEEE 802. 15-08-0360-00-0006 Submission May 2008 Sung Dong Lee, InfopiaSlide 1 Project: IEEE P802.15 Working Group for Wireless Personal Area Networks (WPANs) Submission Title: Continuous glucose monitoring Date Submitted: [xx May, 2008] Source: Gu Youn Kim, Sung Dong Lee[Infopia], Yoon Seok Nam, Hyung Soo Lee[ETRI] Contact: Gu Youn Kim, Infopia, Korea Voice: :+82-31-423 6170, E-mail:gykim@infopia21.com Re: [n/a] Abstract: Provide needs of continuous glucose monitoring and applications of continuous glucose monitoring system Purpose: To provide applications of continuous glucose monitoring system and issue a point-to-multipoint control in medical devices Notice:This document has been prepared to assist the IEEE P802.15. It is offered as a basis for discussion and is not binding on the contributing individual's or organization's. The material in this document is subject to change in form and content after further study. The contributor's reserves the right to add, amend or withdraw material contained herein. Release:The contributor acknowledges and accepts that this contribution becomes the property of IEEE and maybe made publicly available by P802.15.

2. doc.: IEEE 802. 15-08-0360-00-0006 Submission May 2008 Sung Dong Lee, InfopiaSlide 2 Overview of presentation Needs of Continuous Glucose Monitoring Enzymatic Glucose Sensor Continuous Glucose Monitoring System Working procedure Insulin Pump and Glucose Sensor Networking Scenarios Issues

3. doc.: IEEE 802. 15-08-0360-00-0006 Submission May 2008 Sung Dong Lee, InfopiaSlide 3 Increasing number of people with diabetes To improve therapy and hypoglycemia awareness; –Continuous glucose monitoring can reduce hemoglobin A1C levels when compared with fingersticks alone, which in turn can reduce the risk of longterm health complications. To improve the REAL-life decisions through new insights on the impact of daily activities on the glucose control. Needs of Continuous Glucose Monitoring

4. doc.: IEEE 802. 15-08-0360-00-0006 Submission May 2008 Sung Dong Lee, InfopiaSlide 4 Enzymatic Glucose Sensor The glucose passing through the membrane is oxidized by the enzyme glucose oxidase. Reduced glucose oxidase can then be oxidized. Hydrogen peroxide is oxidized into water and generates current which can be measured at the electrode surface(working electrode).

5. doc.: IEEE 802. 15-08-0360-00-0006 Submission May 2008 Sung Dong Lee, InfopiaSlide 5 Continuous Glucose Monitoring System Transmitter Receiver Implantable glucose sensor Transmitter with implantable glucose enzymatic sensor –Transmits glucose sensing data Receiver with display and inter-networking –Store readings, analyze and display

6. doc.: IEEE 802. 15-08-0360-00-0006 Submission May 2008 Sung Dong Lee, InfopiaSlide 6 The sensor is placed on the back of upper arm or abdomen, and is held there with a special adhesive. –A tiny filament 5mm long (as thin as several strands of hair) goes just under the skin. The transmitter attached with the sensor sends glucose readings to the wireless receiver. The receiver stores all glucose readings, and it gives an accurate changes of the glucose. Data record –288 glucose readings per day (a readings / 5 min) – for up to 60 days Working procedure

7. doc.: IEEE 802. 15-08-0360-00-0006 Submission May 2008 Sung Dong Lee, InfopiaSlide 7 Insulin Pump and Glucose Sensor Glucose sensor Insulin pump may be a transmitter of the implantable glucose monitoring system. The insulin pump transmits data wirelessly to a dongle connected to a computer. Data from sensor and insulin pump can be utilized by Diabetes' therapy management software solutions. Insulin pump (Medtronic)

8. doc.: IEEE 802. 15-08-0360-00-0006 Submission May 2008 Sung Dong Lee, InfopiaSlide 8 Networking Scenarios Scenario-1 : Point-to-point –Sensor  Monitoring system –Sensor  Monitoring system  Gateway  Internet Scenario-2 : Point-to-Multipoint –Assume environment of in-body and on-body sensors/actuators –Sensors & Actuators  Gateway  Internet –Sensors & Actuators  WBAN coordinator  Gateway  Internet

9. doc.: IEEE 802. 15-08-0360-00-0006 Submission May 2008 Sung Dong Lee, InfopiaSlide 9 Issues In medical / healthcare applications –Single coordinator or integrated controller with the functions : platform, display, point-to-multipoint control, and so on. –An on-body controller may communicate with implant sensors. –What about an on-body controller with implant medical devices including actuators. Problems –We need point-to-multipoint control. Medical devices under regulatory : Point-to-point control How to solve ? –How to grantee the integrated controller ? System reliability may be related to safety.

10. doc.: IEEE 802. 15-08-0360-00-0006 Submission May 2008 Sung Dong Lee, InfopiaSlide 10 Thank You ! Questions ?