Presentation on theme: "CENTER OF KNOWLEDGE AND TECHNOLOGIES TRANSFER Elena Guseva 1 Natalia Menshutina 1, Hans Leuenberger 2 1 D.I. Mendeleev University of Chemical Technology."— Presentation transcript:
CENTER OF KNOWLEDGE AND TECHNOLOGIES TRANSFER Elena Guseva 1 Natalia Menshutina 1, Hans Leuenberger 2 1 D.I. Mendeleev University of Chemical Technology of Russia 2 University of Basel, Switzerland
In the beginning… Russian-Swiss science and education center for transfer of biopharmaceutical technologies has been established on the basis of MUCTR as the result of team-work between the Institute of Pharmaceutical Technology, University of Basel and MUCTR. The Russian-Swiss science and education center has the official status of the structural unit of MUCTR. The Center is a new basis to enhance the Russian-Swiss relationship in education, science and technology transfer for mutual benefit. The center was founded under support of: Russian Ministry of Education and Science State Secretariat for Education and Research SER Swiss Embassy in Moscow
MAIN AIMS AND TASKS co-ordination of students education on special master courses using the Centres facilities, equipment and materials in accordance with European standards and technical requirements; organisation of specialised laboratories within the university for the purpose of conducting scientific studies profile; advanced training of specialists from appropriately profiled enterprises; publication of relevant successes and popularization of intellectual achievements of Russian and Swiss research organization to improve commercial appeal to the international market.
EDUCATIONAL ACTIVITY graduate unique specialists promote knowledge to practice cultivate understanding of technology We grow people for you INDUSTRYUNIVERSITIES Technology + Equipment Competent specialists (Masters, PhDs)
TRAINING OF SPECIALISTS Improvement of skills and training courses were developed for Russian pharmaceutical specialists: «Technologies and equipment for pharmaceutical industry» Granulation, Drying, Coating (together with Glatt, Huettlin, BASF, Evonik) Quality management PAT …
WEB-PORTAL «PHARMACEUTICS ONLINE» Availability Quality Usability A lot of classified information, useful for education of specialists in pharmaceutics technology area: Videos (with audio explanations) High-quality photos 2D and 3D animations, explaining physical and chemical processes, processes taking place inside apparatus Schemes of general types of apparatus Textual information with binding hyperlinks Technical descriptions of all the processes, useful in pharmaceutics technology
COURSE MATERIALS. LECTURES Dosage dispersed forms (671 slides) Solid drugs forms (~400 slides) Liquid sterile drug forms (~250 slides) Equipment and Technologies of Pharmaceutical Industry (~700 slides, 18 lectures)
OUR BOOKS «Nanoparticles and nanostructured materials for pharmaceutics» Menshutina N.V. «Information systems and databases for pharmaceutics» Menshutina N.V., Mesheryakova T.V., Goncharova S.V., Mishina Y.V., Leuenberger H. – M., MUCTR 2002 «E-learning on chemical engineering and pharmaceutical specialities» Menshutina N., Mishina Ju., Guseva E., Leuenberger H., Chelnokov V. – М., publishing house of scientific literature, Kaluga 2007
Visits, Abroad Studying, Lectures LAST 2 YEARS: Students - 8 Ph.D. Students – 14 Lecturers – 18 Abroad studying – 2 EXCHANGE OF KNOWLEDGE
EQUIPMENT HUTTLIN Mycrolab /HUTTLIN GmbH/ Mini-Glatt /GLATT International GmbH/ Spray drying equipment /NIRO/ Equipment for production micro- and nanoparticles by dispersion /Own development/ AMETEK Proline Process Mass Spectrometer Reverse osmosis equipment R02-50/CP-HR Oil-Free compressor Atlas-Copco Compressor F.F. Vacuum compressor Bioreactor SKAN Isolator equipment Sonotec Ultra-sonic nozzle
RESEARCH AND CONSULTING Pharmaceutics –Freeze, Spray, Supercritical drying –Dispersion –Coating –Granulation –Encapsulation Biotechnology –stress of microorganism –protein production Nanotechnology –drug delivery Information technology –PAT, LIMS –Software development Development of new technologies and Scaling-up:
ENCAPSULATION Encapsulation by coating in fluidized layer under super critical conditions Protein encapsulation to biodegradable microspheres using freeze drying technologies
Mannitol Dextran Spraying Freezing Sublimation of fluidized bed particles Atmospheric freeze-drying with active hydrodynamics … is alternative process to classical vacuum freeze- drying
The process has two stages: the initial freezing at spraying of the solution the sublimation of frozen particles at their fluidization The initial freezing is done in a freezing cabinet, which is equipped with an ultrasonic nozzle that is capable of producing particles of 150 mm. The freezing temperature inside the cabinet was held at –60 C. The 15% aqueous solution of mannitol is sprayed top-down against a cold air stream. At sublimation drying stage of the process the frozen particles are held by fluidization, and this was performed in the modified Glatt apparatus. The process was carried out at a drying temperature of about -20ºC. The average time of the process was about 3 hours. The main stages and description of the process
intensive heat and mass transfer, high moisture removal rate due to active hydrodynamic regime reduced time of the process energy effectiveness in comparison with classical freeze drying under vacuum better control of the residual moisture content and temperature, important for pharmaceutical products product size and shape design for manufacturing of solid dosage forms and production of injection and inhalation dosage form possibility of continuous operation The advantages of the atmospheric freeze drying with active hydrodynamics
The properties of the pharmaceutical products preserved of natural structure and nutrients pre-specified particle size (nano- or microparticles) high porosity high specific and internal surface area of particles solubility and bioavailability free flowing powder spherical particle shape …
Comparison of spray drying and atmospheric spray-freeze drying Spray drying particles Spray-freeze drying particles
Comparison of vacuum freeze- drying and atmospheric spray-freeze drying pre-specified particle size (nano- or microparticles) high porosity free flowing powder spherical particle shape product size and shape design for manufacturing of solid dosage forms and production of injection and inhalation dosage form possibility of continuous operation
Shape and Structure of Particle Spray drying particles Vacuum-freeze drying particles
Atmospheric Spray Freeze Drying as an Alternative Advantages: The result is a highly porous free flowing powder (pellets) with instant solubility properties. The high porosity of the pellets (up to 85%) and the nanostructured internal surface is ideal for the formulation of novel drug delivery systems for the lung.
Atmospheric Spray Freeze Drying as an Alternative Advantages: Process is faster due to the better heat transfer and has a lower variability. It is possible to combine the advantages of Nano- and Microtechnology.
Atmospheric Spray Freeze Drying as an Alternative Advantages: ideal for the preparation of nanocomposite pellets for low water soluble drugs to enhance bioavailability of the drug. ideal for the formulation of temperature and structure sensitive drugs such as Biologicals i.e. Pharmaproteins such as Interferons, Insulin.
TECHNOLOGY TRANSFER equipment selection design and scaling-up process flowsheet optimization mathematical models modeling tools
KINETICS Drying driving force Combined heat and mass transfer inside particle Interface processes HYDRODYNAMICS HEAT AND MASS TRANSFER IN APPARATUS DETERMINATION OF STABLE OPERATION MODE OPTIMIZATION DESIGN SCALING-UP CONTROL Modelling of the atmospheric freeze drying with active hydrodynamics
Modeling of hydrodynamics, heat-and mass- transfer in apparatus The equations of mass, concentration preservation are: The equations of impulse preservation are: The equations of energy preservation are: Additional correlations are: Height, m Velocity, m/s
The drying kinetics The driving force of process: The drying rate: J = X The effective mass transfer coefficient: = NuD/l 1 > 2 The main influencing factor on the value of the driving force of atmospheric freeze drying is the flow of injected heat into the product, and outflow of water at sublimation.
The mathematical model solution The solution of equations system allowed to investigate the hydrodynamic and temperature regimes (gas and particle velocities, temperature, void volume etc.), heat and mass transfer in any point of the apparatus, as well as to determine the drying rate. Moreover, on the basis of the mathematical model it is possible to find parameters for stable operation of a dryer, for example the height of a fountain.
The example of the drying kinetics modelling in apparatus II for d=150 m, V 1inlet =0,30 m/s
The apparatus design and scale-up the process
The comparison of energy efficiency of atmospheric and vacuum freeze-drying Instantaneous energy efficiency Time, min Vacuum freeze drying Atmospheric freeze drying th WORLD CONGRESS of CHEMICAL ENGINEERING 24
the atmospheric freeze-drying with active hydrodynamics is an innovative technology for production of pharmaceutical nano- and micro- powders with pre-specified structure and properties the mathematical model based on the mechanics of heterogeneous media and non-equilibrium thermodynamics has been developed and verified to define main operation parameters on the basis of a mathematical model the drying simulator has been developed also, a energy efficiency analysis of atmospheric freeze drying was carried out; in comparison with classical freeze-drying it is more energy efficient the approach proposed allows modeling, design and control of the processes described Conclusions
TECHNOLOGY TRANSFER AND PROMOTION Conferences Seminars Round tables Exhibitions Publications Website …
The Third Russian-Swiss seminar Pharminnovations 5-6 December, 2006
HÜTTLIN GmbH (Germany) NOVARTIS (Switzerland)
BIOTECHNOLOGY March «Quality management key factor in the development of pharmaceutical industry»
Our Partners Московская медицинская академия им И.М. Сеченова Join us! Welcome to Russian-Swiss Center!