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OBTEC Wipo Regional Workshop on Patent Analytics WIPO & INPI Rio de Janeiro, August 26 a 28, 2013 Samples of Patent Analytics Observatory of Tecnologies.

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Presentation on theme: "OBTEC Wipo Regional Workshop on Patent Analytics WIPO & INPI Rio de Janeiro, August 26 a 28, 2013 Samples of Patent Analytics Observatory of Tecnologies."— Presentation transcript:

1 OBTEC Wipo Regional Workshop on Patent Analytics WIPO & INPI Rio de Janeiro, August 26 a 28, 2013 Samples of Patent Analytics Observatory of Tecnologies - INPI/ Brazil Prof. Adelaide Antunes

2 OBTEC OBTEC / INPI Created in 2010, the Observatory stimulates the interaction between Brazilian Office and the several stakeholders of the Brazilian National Innovation System (Universities, Research Institutes, Finance Organizations, Government Agencies) Observatory of Technologies Strategic utilization of IP System in favor of the economic development.

3 OBTEC Wipo Regional Workshop on Patent Analytics Observatory of Tecnologies - INPI/ Brazil It´s necessary to identify the needs To develop a Strategy To search for information To analyse To disseminate Reports (patents) University (papers) INPI (Government) Industries Innovation Economic Development

4 OBTEC Partnership INPI – OBTEC / FINEP (Funding Authority for Studies and Projects) Observatory in the Health Sector COOPERATION AGREEMENT FINEP –goal: Introduce IP Culture Brands / Patents

5 OBTEC EX.: EMS Trademarks Company SectorTrademarks (applications) Pending applications Registered trademarks Dead trademarks Frist Application Latest Application E M SDrugs Nov., 1963June, 2012 Priority Country Patent Documents Brazil7 Great Britain3 Patents Major Generic Drug Company (80% incoming)

6 OBTEC STUDIES - DRUGS- FINEP Grupo I - Tipo i Capítulo da NCM Medicamentos a base dos fármacos Atazanavir Ganciclovir Gosserelina Hidroxiuréia Indinavir Sulfato Insulina Isoniazida/Rifampicina/Pirazinamida/Etambutol Levotiroxina Mitoxantrona Talidomida Regra de origem: salto de posição tarifária, exceto do capítulo 30

7 OBTEC Ganciclovir RN: IUPAC: 2-amino-1,9-dihydro-9-[[2-hydroxy-1- (hydroxymethyl)ethoxy]methyl]-6H-Purin-6-one Therapeutic class: antiviral Names and brands 2-Amino-1,9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]6H-purin-6-one Biolf 62 BN-B759V Gansikloviiri Gansiklovir Gancyclovir Gancyklovir Ganecicilovir Gansikloviiri Gansiklovir HSDB 6512

8 OBTEC Ganciclovir Labs Brasil (DEF) Roche Halex Istar Blausiegel Lafepe Eurofarma Producers(DWCP) – 38 China - 24 Índia - 4 Alemanha - 3 Estados Unidos - 2 Argentina, Brasil, Canadá, França, Itália – 1 N º Priority documents / Country China - 18 EUA - 5 Índia - 5 Escritório Europeu de Patentes - 2 (Itália e França) Espanha e a Itália - 1 depósito cada.

9 OBTEC Partnership INPI – OBTEC / FIOCRUZ Oswaldo Cruz Foundation Science at Service of Life Observatory in the Health Sector COOPERATION AGREEMENT

10 OBTEC Partnership INPI (OBTEC) / FIOCRUZ to identify global trends in cancer subsidize decision-making processes in the Brazilian healthcare sector Definition of (Brazilian) priorities Important to know the Patent landscape on cancer drugs not-patented technologies patents that have expired

11 OBTEC Partnership INPI (OBTEC) / FIOCRUZ patent documents related to cancer drugs (worldwide) Derwent Innovations Index


13 OBTEC Trends in Nanopharmaceutical Patents call for papers: International Journal of Molecular Sciences (2013) Trends in Nanopharmaceutical Patents Case Study Adelaide Antunes1, Iolanda Fierro1, Rafaela Guerrante1, Flavia Mendes2 and Maria Simone de M. Alencar3 1 INPI; 2 UFRJ ; 3 FIOCRUZ Scientific journal

14 OBTEC Methodology Data BaseDerwent Innovations Index Main Advantages The summaries are full of keywords The possibility of exporting the patent documents recovered in the search using software (Vantage Point) The availability of Manual Code related to nanotechnology (classification attributed in the database to all patent documents indexed in it) Selection of documents that were indexed between 2002 and 2012 in the Derwent database

15 OBTEC Manual Codes related to nanotechnology applied to the pharmaceutical sector, and the number of patent documents Derwent manual code Description Number of patent documents B12-M11QNanoparticles2,306 B12-M10A7Nanotechnology devices160 B11-C12Nanotechnology (general)5,028 B05-U05ANanotubes, nanorods or nanohorns 100 B05-U05Bnanofilms B05-U05C Nanostructures, other than those covered by B05-U05A and B05-U05B B05-U05Other carbon containing 3-D structures44 B05-U04Carbon plus heteroatom nanotubes40 B05-U03Carbon-only nanotubes615 Removing the patent document that were in more than one of the nine series toxicity and nanoparticle nano-imaging agent nanoparticle for drug delivery cancer-targeting nanoparticle Focus on Special Issue Bioactive Nanoparticle 2012

16 OBTEC Results

17 The main patent applicant by area Total of patents Entity applying for patents Toxicity of nanoparticle Nano- imaging agent Nanoparticle for drug delivery Cancer- targeting nanoparticle 23Univ. of California Massachusetts Inst. Technology General Electric Co Univ. Nat. Tsing Hua GP Medical Inc Univ. Texas System0656 8Univ. Northwestern0006 8Elan Pharma Int. Ltd7000 8Konink Philips Electronics NV Centre National de La Recherche Scientifique (CNRS) Abraxis Bioscience LLC7000 7Fuji Film Co Ltd Brigham & Women s Hospital Inc Univ. Kyushu0050

18 OBTEC MIT Partnerships MIT nanoparticles for use in encapsulating a biologically active agent (e.g., polynucleotide) Advantage is in effectively providing low immunogenicity and toxicity Universities and Hospitals

19 OBTEC Chapter 5 - The Contribution of Information Science through Intellectual Property to Innovation in the Brazilian Health Sector Adelaide Maria de Souza Antunes, Flavia Maria Lins Mendes, Suzanne de Oliveira Rodrigues Schumacher, Luc Quoniam, Jorge Lima de Magalhães Rethinking The Conceptual Base For New Practical Applications In The Information Value And Quality (IGI Global 2014 USA)

20 OBTEC Brazil Health System (SUS) Section 1: Pharmaceuticals industry, made up of six groups Group 1 – Antivirals (including antiretrovirals) Group 2 – Neglected Diseases Group 3 – Chronic non-communicable diseases Group 4 – Biological pathways Group 5 – Vaccines and Hemoderivatives Group 6 – Medications and inputs for the treatment of medical issues resulting from nuclear accidents. Section 2: Medical devices and healthcare devices in general

21 OBTEC Methodology Database used to access the patent documents: SciFinder Scholar Search for each drug, using the CAS Registry Number Informations patents relating to processes (synthesis and/or formulation); main Applicants (assignees) top countries information about the first patent for the drug, date and respective assignee patents filed in Brazil trends over time of patenting

22 OBTEC Atorvastatin Atorvastatin (CAS RN: ) 114 process patents 84 are for its synthesis 26 for its formulation 4 for its synthesis and formulation Companies with the most patents (eight each) Teva Pharmaceuticals Industries Warner-Lambert Company First patent 1986 Warner-Lambert Company Brazil (17 deposits) Warner Lambert Company (five for synthesis and one for formulation) Teva Pharmaceuticals Industries (one for formulation and one for synthesis) Pfizer (synthesis)

23 OBTEC Calcitonin Calcitonin (CAS RN: ) 204 process patents 169 are for its synthesis 28 for its formulation 7 for its synthesis and formulation Companies with the most patents Armour Pharmaceutical (USA) - 9 First patent 1968 Ciba Ltd (Switzerland) Brazil (10 patents) 2 for synthesis by Institut Gustave Roussy (France),

24 OBTEC III Academic Intelectual Property and Innovation Development Meeting ( III ENAPID - INPI 2010) Key Structures on Synthesis of HIV drugs III Academic Intelectual Property and Innovation Development Meeting ( III ENAPID - INPI 2010) Key Structures on Synthesis of HIV drugs Adelaide Maria de Souza Antunes 1, Rodrigo José Ávila Cartaxo 2, Flavia Maria Lins Mendes 2 1 INPI; 2 UFRJ Scientific journal

25 OBTEC Top Applicants: Merck & Co - 15 patentes Bristol-Myers Squibb Co - 10 patentes 54% em PCT Technology domination: EUA – 40% China, Índia e Japan – 41% 19 HIV / SciFinder (CAS/ACS) Busca: RN

26 OBTEC Methodology – 19 HIV

27 OBTEC KEY Chemical Substances Analysis for HIVs 5-M ETHYLURIDINE Zidovudine Estavudine Bristol-Myers (US) and Ajinomoto (JP) 4 routes2 routes Bristol-Myers, Ajinomoto, Japan Tobacco and China Pharmacy Univ 24 producers : 16 China, 2 Canada, 2 USA, 1 Italy, 1 Korea, 1 Slovakia and 1 Rússia

28 OBTEC Thesis Luiz André Felizardo S. Schlittler (EQ/UFRJ) Advisers: Prof. Nei Pereira Jr./ Profa. Adelaide Antunes(INPI) Mapping technological knowlodge of ethanol 2º Generation

29 OBTEC Genetic modification micro-organims Others compounds production Enzyme production Enzymatic hydrolysis Produção de etanol 2G Midwest R. Inst. Univ. Florida Technological focus

30 OBTEC Thesis Maria Simone de Menezes Alencar (EQ/UFRJ) Adviser: Adelaide Maria de Souza Antunes (INPI) Technological Foresight applied nanotechnology

31 OBTEC THERMS (strategy) Base de dados: Derwent Innovation Index

32 OBTEC Results Top countries

33 OBTEC Analysis

34 Patenting in The US NANOINTERMEDIATES: biosensores, dispositivos fotovoltaicos e para armazenamento de memória NANOPRODUCTUS: radiografia industrial, sistemas óticos e de imagem NANOPRODUCTUS : com aplicações em computadores, filmes e automóveis NANOPRODUCTUS dentais, adesivos e revestimentos dentais e equipamentos ortodônticos. CLUSTER 1

35 OBTEC Estratégia de Inovação e Tecnologia em Sementes. Thesis Rafaela Guerrante (EQ/UFRJ) advisers: Prof. Nei Pereira Jr. e Profa. Adelaide Maria de Souza Antunes Innovation Strategy and Technology in Seeds Agriculture

36 OBTEC Case Study – Monsantos patents on GURT (genetic use restriction technology) GURT technology colloquially known as terminator/traitor technology causes second generation seeds to be sterile Terminator the use of an external chemical inducer which turns "on or off" a plant's genetic traits (ex. sterility) Traitor There are not specific keywords/IPCs to describe GURT technology 1224 Monsantos patent documents were retrieved, possibly related to GURT In order to validate the results and analyze the technologies described in the patents retrieved, a methodology was developed.

37 OBTEC Reading of CLAIMS and/or DESCRIPTION Reading of TITLE and/or ABSTRACT Methodology 1st step

38 OBTEC resistance to increased grain yield increased growth rate Filter sterile) AND 756 documents 764 docs. MA Reading of CLAIMS and DESCRIPTION DISCARD herbicide tolerance Filter using AND/OR pest resistance tolerance to Reading of CLAIMS and DESCRIPTION - (sterility OR male Terminator 779 documents 9 documents related to LE-STERILITY 1 doc. NOT RELATED 8 documents 765 documents 14 documents NOTRELATED DO NOT CONTAIN - (sterility OR sterile) AND male + Methodology 2st step

39 OBTEC Patent and Publications Networks related to Dengue and HPV vaccines: its implications for policy of innovation in health Thesis Priscila Rohem-Santos (IE/UFRJ) Advisor: Claudia Inês Chamas

40 OBTEC Survey design and data sources / Analysis The methodology of analysis involves: The search strategy encompasses definition of : keywords IPC and Derwent Manual codes database I – Identification of Dengue and HPV vaccine patent applications and articles; II – Creation of clusters according to various indicators such as applicant, priority number, validity (legal status); III – Claims' analysis of the applications filed in Brazil. IV – Social Network analysis (coauthorsip/ corinventorship)

41 OBTEC Survey design and data sources / Analysis (3 databases for patents) (3 databases for articles) Merge results of diferent databases Harmonization of names – Thesaurus Ex.: merges/acquisition of pharamautical industries considering the vaccine sector (Aventis Pasteur + Pasteur Meriex Connaugth = Aventis Pasteur (Sanofi) + Panacea + Shanta = Sanofi Pasteur (Homma et al, 2011) Removal of duplicates Adjacency matrices – correlation of data

42 OBTEC RESULTS: HPV articles and patents networks BR

43 OBTEC RESULTS: Dengue articles and patents networks BR Fragility of brazilian researchers conection

44 OBTEC Thanks !!! Adelaide Antunes Elaine Vianna BernanrdoNunes Cristina DUrso Priscila Rohem Rafaela Guerrante

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